Search Results - "Baylis, Richard A."

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis by Alencar, Gabriel F., Owsiany, Katherine M., Karnewar, Santosh, Sukhavasi, Katyayani, Mocci, Giuseppe, Nguyen, Anh T., Williams, Corey M., Shamsuzzaman, Sohel, Mokry, Michal, Henderson, Christopher A., Haskins, Ryan, Baylis, Richard A., Finn, Aloke V., McNamara, Coleen A., Zunder, Eli R., Venkata, Vamsidhar, Pasterkamp, Gerard, Björkegren, Johan, Bekiranov, Stefan, Owens, Gary K.

“…Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we…”
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Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis by Hess, Daniel L., Kelly-Goss, Molly R., Cherepanova, Olga A., Nguyen, Anh T., Baylis, Richard A., Tkachenko, Svyatoslav, Annex, Brian H., Peirce, Shayn M., Owens, Gary K.

“…The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC)…”
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Clustering cancers by shared transcriptional risk reveals novel targets for cancer therapy by Gao, Hua, Baylis, Richard A, Luo, Lingfeng, Kojima, Yoko, Bell, Caitlin F, Ross, Elsie G, Wang, Fudi, Leeper, Nicholas J

“…To explore the clinical actionability of these findings, we leveraged the drug prediction algorithm, OCTAD [1] to: (1) determine whether any promising…”
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Endothelial-to-Mesenchymal Transition in Atherosclerosis: Friend or Foe? by Gole, Sarin, Tkachenko, Svyatoslav, Masannat, Tarek, Baylis, Richard A, Cherepanova, Olga A

“…Despite many decades of research, complications of atherosclerosis resulting from the rupture or erosion of unstable plaques remain the leading cause of death…”
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Identifying shared transcriptional risk patterns between atherosclerosis and cancer by Baylis, Richard A., Gao, Hua, Wang, Fudi, Bell, Caitlin F., Luo, Lingfeng, Björkegren, Johan L.M., Leeper, Nicholas J.

“…Cancer and cardiovascular disease (CVD) are the leading causes of death worldwide. Numerous overlapping pathophysiologic mechanisms have been hypothesized to…”
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Computational protocol to identify shared transcriptional risks and mutually beneficial compounds between diseases by Gao, Hua, Zhang, Mao, Baylis, Richard A., Wang, Fudi, Björkegren, Johan L.M., Kovacic, Jason J., Ruusalepp, Arno, Leeper, Nicholas J.

“…The accumulation of omics and biobank resources allows for a genome-wide understanding of the shared pathologic mechanisms between diseases and for strategies…”
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Epidemiology and Genetics of Venous Thromboembolism and Chronic Venous Disease by Baylis, Richard A., Smith, Nicholas L., Klarin, Derek, Fukaya, Eri

“…Venous disease is a term that broadly covers both venous thromboembolic disease and chronic venous disease. The basic pathophysiology of venous thromboembolism…”
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The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology by Baylis, Richard A, Gomez, Delphine, Mallat, Ziad, Pasterkamp, Gerard, Owens, Gary K

“…The results of the CANTOS trial provide exciting evidence in support of the inflammatory hypothesis of atherosclerosis in humans, and is the first phase III…”
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Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice by Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Müller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis…”
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Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity by Peske, J. David, Thompson, Elizabeth D., Gemta, Lelisa, Baylis, Richard A., Fu, Yang-Xin, Engelhard, Victor H.

“…The presence of lymph node (LN)-like vasculature in tumours, characterized by expression of peripheral node addressin and chemokine CCL21, is correlated with…”
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Shifting the Focus of Preclinical, Murine Atherosclerosis Studies From Prevention to Late-Stage Intervention by Baylis, Richard A, Gomez, Delphine, Owens, Gary K

“…Could improving the design of preclinical murine atherosclerosis studies help increase the success rate of cardiovascular clinical trials? In this Viewpoint ,…”
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Cancer Incidence After Diagnosis of Abdominal Aortic Aneurysm-Brief Report by Luo, Lingfeng, Haas, Allen M, Bell, Caitlin F, Baylis, Richard A, Adkar, Shaunak S, Fu, Changhao, Angelov, Ivan, Giordano, Sharon H, Klarin, Derek, Leeper, Nicholas J, Nead, Kevin T

“…Epidemiological and mechanistic data support a potential causal link between cardiovascular disease (CVD) and cancer. Abdominal aortic aneurysms (AAAs)…”
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Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction by Shin, Junchul, Tkachenko, Svyatoslav, Chaklader, Malay, Pletz, Connor, Singh, Kanwardeep, Bulut, Gamze B, Han, Young min, Mitchell, Kelly, Baylis, Richard A, Kuzmin, Andrey A, Hu, Bo, Lathia, Justin D, Stenina-Adognravi, Olga, Podrez, Eugene, Byzova, Tatiana V, Owens, Gary K, Cherepanova, Olga A

“…Abstract Aims Until recently, the pluripotency factor Octamer (ATGCAAAT)-binding transcriptional factor 4 (OCT4) was believed to be dispensable in adult…”
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IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice by Karnewar, Santosh, Karnewar, Vaishnavi, Deaton, Rebecca A, Shankman, Laura S, Benavente, Ernest D, Williams, Corey M, Bradley, Xenia, Alencar, Gabriel F, Bulut, Gamze B, Kirmani, Sara, Baylis, Richard A, Zunder, Eli R, den Ruijter, Hester M, Pasterkamp, Gerard, Owens, Gary K

“…Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions is the global leading cause of death. The most common and effective…”
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Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms by Newman, Alexandra A. C., Serbulea, Vlad, Baylis, Richard A., Shankman, Laura S., Bradley, Xenia, Alencar, Gabriel F., Owsiany, Katherine, Deaton, Rebecca A., Karnewar, Santosh, Shamsuzzaman, Sohel, Salamon, Anita, Reddy, Mahima S., Guo, Liang, Finn, Aloke, Virmani, Renu, Cherepanova, Olga A., Owens, Gary K.

“…Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2 + myofibroblast (MF)-like…”
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Risk of Cancer After Diagnosis of Cardiovascular Disease by Bell, Caitlin F., Lei, Xiudong, Haas, Allen, Baylis, Richard A., Gao, Hua, Luo, Lingfeng, Giordano, Sharon H., Wehner, Mackenzie R., Nead, Kevin T., Leeper, Nicholas J.

“…Cardiovascular disease (CVD) and cancer share several risk factors. Although preclinical models show that various types of CVD can accelerate cancer…”
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice by Mahan, Sidney, Liu, Mingjun, Baylis, Richard A, Gomez, Delphine

“…Atherosclerosis remains the leading cause of death worldwide and, despite countless preclinical studies describing promising therapeutic targets, novel…”
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Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds by Newman, Alexandra Ac, Baylis, Richard A, Hess, Daniel L, Griffith, Steven D, Shankman, Laura S, Cherepanova, Olga A, Owens, Gary K

“…The long-term adverse effects of radiotherapy on cardiovascular disease are well documented. However, the underlying mechanisms responsible for this increased…”
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Interleukin-1[beta] has atheroprotective effects in advanced atherosclerotic lesions of mice by Gomez, Delphine, Baylis, Richard A, Durgin, Brittany G, Newman, Alexandra A. C, Alencar, Gabriel F, Mahan, Sidney, St. Hilaire, Cynthia

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis…”
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Interleukin-1β promotes atheroprotective changes of advanced atherosclerotic lesions in mice by Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Muller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. Although a prevailing…”
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