Atypical scrapie in Australia

Atypical scrapie in Australia

Background Since its initial detection in Norway in 1998, atypical scrapie (‘atypical/Nor98 scrapie’) has been reported in sheep in the majority of European countries (including in regions free of classical scrapie) and in the Falkland Islands, the USA, Canada, New Zealand and Australia. Case series...

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Bibliographic Details
Published in:Australian veterinary journal Vol. 94; no. 12; pp. 452 - 455
Main Authors: Cook, RW, Bingham, J, Besier, AS, Bayley, CL, Hawes, M, Shearer, PL, Yamada, M, Bergfeld, J, Williams, DT, Middleton, DJ
Format: Journal Article
Language:English
Published: Melbourne Wiley Publishing Asia Pty Ltd 01-12-2016
Wiley Subscription Services, Inc
Subjects:
Animals
atypical scrapie
Australia
Bovine spongiform encephalopathy
Brain - pathology
Female
Neuropil - pathology
prion disease
PrPSc Proteins - analysis
Rodents
Scrapie - diagnosis
Scrapie - pathology
Sheep
transmissible spongiform encephalopathy
Vacuoles - pathology
atypical scrapie
prion disease
transmissible spongiform encephalopathy
sheep
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Summary:Background Since its initial detection in Norway in 1998, atypical scrapie (‘atypical/Nor98 scrapie’) has been reported in sheep in the majority of European countries (including in regions free of classical scrapie) and in the Falkland Islands, the USA, Canada, New Zealand and Australia. Case series The diagnosis in Australia of atypical scrapie in four Merino and one Merino‐cross sheep showing clinical signs of neurological disease was based on the detection of grey matter neuropil vacuolation (spongiform change) in the brain (particularly in the molecular layer of the cerebellar cortex) and associated abnormal prion protein (PrPSc ) deposition in both grey and white matter. Changes were minimal in the caudal brainstem, the predilection site for lesions of classical scrapie. Conclusion The distinctive lesion profile of atypical scrapie in these five sheep highlights the diagnostic importance of routine histological evaluation of the cerebellum for evidence of neuropil vacuolation and associated PrPSc deposition in adult sheep with suspected neurological disease.
Bibliography:istex:79AC7E97E0DD2C50BD918BA2A5D6821E8F73169D
ArticleID:AVJ12529
ark:/67375/WNG-N45BFVFN-M
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0005-0423
1751-0813
DOI:10.1111/avj.12529