Search Results - "Bayer, Abraham"

MyD88: At the heart of inflammatory signaling and cardiovascular disease by Bayer, Abraham L., Alcaide, Pilar

“…Cardiovascular disease is a leading cause of death worldwide and is associated with systemic inflammation. In depth study of the cell-specific signaling…”
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Deletion of MyD88 in T Cells Improves Antitumor Activity in Melanoma by Bayer, Abraham L., Padilla-Rolon, Darwing, Smolgovsky, Sasha, Hinds, Philip W., Alcaide, Pilar

“…Cytotoxic CD8+ T cells are central to the antitumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by…”
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Deletion of MyD88 in T‐Cells Worsens Cardiac Pathology Through Enhanced T‐Cell Survival and Induction of Cardiac Fibrosis by Bayer, Abraham L., Smolgovsky, Sandra, Ngwenyama, Njabulo, Aronovitz, Mark, Kaur, Kuljeet, Alcaide, Pilar

“…Heart failure (HF) is a leading cause of death worldwide, associated with cardiac and systemic inflammation. However, no anti‐inflammatory therapies have shown…”
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T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation by Bayer, Abraham L., Smolgovsky, Sasha, Ngwenyama, Njabulo, Hernández-Martínez, Ana, Kaur, Kuljeet, Sulka, Katherine, Amrute, Junedh, Aronovitz, Mark, Lavine, Kory, Sharma, Shruti, Alcaide, Pilar

“…Cardiac inflammation in heart failure is characterized by the presence of damage-associated molecular patterns, myeloid cells, and T cells. Cardiac…”
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Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction by Smolgovsky, Sasha, Bayer, Abraham L, Kaur, Kuljeet, Sanders, Erin, Aronovitz, Mark, Filipp, Mallory E, Thorp, Edward B, Schiattarella, Gabriele G, Hill, Joseph A, Blanton, Robert M, Cubillos-Ruiz, Juan R, Alcaide, Pilar

“…Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited therapeutic options and poorly understood immune pathophysiology…”
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A Modular Turn‐On Strategy to Profile E2‐Specific Ubiquitination Events in Living Cells by Hill, Caitlin J., Datta, Suprama, McCurtin, Nicholas P., Kimball, Hannah Z., Kingsley, Molly C., Bayer, Abraham L., Martin, Alexander C., Peng, Qianni, Weerapana, Eranthie, Scheck, Rebecca A.

“…A cascade of three enzymes, E1−E2−E3, is responsible for transferring ubiquitin to target proteins, which controls many different aspects of cellular…”
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AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma by Bayer, Abraham L, Pietruska, Jodie, Farrell, Jaymes, McRee, Siobhan, Alcaide, Pilar, Hinds, Philip W

“…Cellular senescence is a carefully regulated process of proliferative arrest accompanied by functional and morphologic changes. Senescence allows damaged cells…”
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AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis by McRee, Siobhan K, Bayer, Abraham L, Pietruska, Jodie, Tsichlis, Philip N, Hinds, Philip W

“…Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer due to its highly metastatic nature. Melanomas harboring oncogenic…”
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Endothelial STING controls T cell transmigration in an IFNI-dependent manner by Anastasiou, Marina, Newton, Gail A, Kaur, Kuljeet, Carrillo-Salinas, Francisco J, Smolgovsky, Sasha A, Bayer, Abraham L, Ilyukha, Vladimir, Sharma, Shruti, Poltorak, Alexander, Luscinskas, Francis W, Alcaide, Pilar

“…The stimulator of IFN genes (STING) protein senses cyclic dinucleotides released in response to double-stranded DNA and functions as an adaptor molecule for…”
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Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction by Bayer, Abraham L, Zambrano, Maria A, Smolgovsky, Sasha, Robbe, Zachary L, Ariza, Abul, Kaur, Kuljeet, Sawden, Machlan, Avery, Anne, London, Cheryl, Asnani, Aarti, Alcaide, Pilar

“…Doxorubicin, the most prescribed chemotherapeutic drug, causes dose-dependent cardiotoxicity and heart failure. However, our understanding of the immune…”
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A Modular Turn‐On Strategy to Profile E2‐Specific Ubiquitination Events in Living Cells by Hill, Caitlin J., Datta, Suprama, McCurtin, Nicholas P., Kimball, Hannah Z., Kingsley, Molly C., Bayer, Abraham L., Martin, Alexander C., Peng, Qianni, Weerapana, Eranthie, Scheck, Rebecca A.

“…A cascade of three enzymes, E1−E2−E3, is responsible for transferring ubiquitin to target proteins, which controls many different aspects of cellular…”
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Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin by Lim, Pei Jin, Duarte, Tiago L., Arezes, João, Garcia-Santos, Daniel, Hamdi, Amel, Pasricha, Sant-Rayn, Armitage, Andrew E., Mehta, Hema, Wideman, Sarah, Santos, Ana G., Santos-Gonçalves, Andreia, Morovat, Alireza, Hughes, Jim R., Soilleux, Elizabeth, Wang, Chia-Yu, Bayer, Abraham L., Klenerman, Paul, Willberg, Christian B., Hartley, Richard C., Murphy, Michael P., Babitt, Jodie L., Ponka, Prem, Porto, Graça, Drakesmith, Hal

“…Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The…”
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Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin by Lim, Pei Jin, Duarte, Tiago L, Arezes, João, Garcia-Santos, Daniel, Hamdi, Amel, Pasricha, Sant-Rayn, Armitage, Andrew E, Mehta, Hema, Wideman, Sarah, Santos, Ana G, Santos-Gonçalves, Andreia, Morovat, Alireza, Hughes, Jim R, Soilleux, Elizabeth, Wang, Chia-Yu, Bayer, Abraham L, Klenerman, Paul, Willberg, Christian B, Hartley, Richard C, Murphy, Michael P, Babitt, Jodie L, Ponka, Prem, Porto, Graça, Drakesmith, Hal

“…Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The Nrf2…”
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Abstract P3078: The Stimulator Of Interferon Genes (STING) Modulates Adverse Cardiac Remodeling Induced By Cardiac Pressure Overload: New Role Of Endothelial Cell Sting In Systolic Dysfunction by Sanders, Erin, Wagner, Noah, Smolgovsky, Sasha, Bayer, Abraham, Theall, Brandon, Aronovitz, Mark, Kaur, Kuljeet, Alcaide, Pilar

“…Abstract only Introduction: Cardiac inflammation is a hallmark of heart failure (HF) defined by T cell infiltration and increased expression of…”
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Abstract P3064: Cytotoxic T-cells Drive Doxorubicin Induced Cardiac Fibrosis And Systolic Dysfunction by Bayer, Abraham L, Zambrano, Maria, Elwell, Hannah, Smolgovsky, Sasha, kaur, Kuljeet, Asnani, Aarti, Alcaide, Pilar

“…Abstract only Background: Doxorubicin (DR), the most commonly prescribed chemotherapy, results in dose-dependent cardiotoxicity and heart failure (HF), and…”
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Abstract Tu084: Endothelial Cell STING contributes to Systolic Dysfunction by modulating cardiomyocyte hypertrophy and capillary density in pressure overload-induced heart failure by Sanders, Erin, Wagner, Noah, Bayer, Abraham, Smolgovsky, Sasha, Theall, Brandon, aronovitz, mark, Blanton, Robert, kaur, Kuljeet, Alcaide, Pilar

“…Abstract only Introduction: Cardiomyocyte (CM) hypertrophy, endothelial cell (EC) dysfunction and cardiac inflammation are hallmarks of adverse cardiac…”
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Abstract We075: Stimulator of Interferon Genes (STING) Regulates T Cell Fate in Cardiometabolic Heart Failure with Preserved Ejection Fraction (HFpEF) by Smolgovsky, Sasha, Bayer, Abraham, Emig, Ramona, Magri, Zoie, aronovitz, mark, kaur, Kuljeet, Poltorak, Alexander, Blanton, Robert, Alcaide, Pilar

“…Abstract only Introduction: Combined obesity and hypertension alter the endoplasmic reticulum (ER) stress response by downregulating X-box binding protein 1 (…”
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Abstract Tu096: The Aryl Hydrocarbon Receptor Agonist, L-Kynurenine, Modulates Cardiac Fibroblast Activation and Antigen Presentation by Theall, Brandon, Smolgovsky, Sasha, Bayer, Abraham, Sanders, Erin, Zambrano, Maria, Robbe, Zachary, aronovitz, mark, kaur, Kuljeet, Alcaide, Pilar

“…Abstract only Background: The Aryl Hydrocarbon Receptor (AHR) is a ubiquitously expressed transcription factor that regulates the cellular response to external…”
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Abstract P3062: T-cell Myd88 Regulates Cardiac Fibrosis In Heart Failure By Modulating T-cell Survival And Pro-inflammatory Signaling by Bayer, Abraham L, Smolgovsky, Sasha, Ngwenyama, Njabulo, Aronovitz, Mark, kaur, Kuljeet, Alcaide, Pilar

“…BackgroundDespite the association of heart failure (HF) with cardiac and systemic inflammation, anti-inflammatory therapies have shown limited success. Cardiac…”
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Abstract 4118086: Doxorubicin Induces a Cytotoxic T-cell Inflammatory Response That Contributes to Cardiac Fibrosis and Systolic Dysfunction by Bayer, Abraham, Zambrano, Maria, Smolgovsky, Sasha, Robbe, Zachary, Ariza, Abul, kaur, Kuljeet, Sawden, Machlan, Avery, Anne, London, Cheryl, Asnani, Aarti, Alcaide, Pilar

“…Abstract only Background: Doxorubicin (DR), the most commonly used chemotherapy, results in dose-dependent cardiotoxicity in part by causing oxidative stress,…”
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