Search Results - "Baxter, Patricia A"

Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models by Zhang, Huiyuan, Du, Yuchen, Qi, Lin, Xiao, Sophie, Braun, Frank K, Kogiso, Mari, Huang, Yulun, Huang, Frank, Abdallah, Aalaa, Suarez, Milagros, Karthick, Sekar, Ahmed, Nabil M, Salsman, Vita S, Baxter, Patricia A, Su, Jack M, Brat, Daniel J, Hellenbeck, Paul L, Teo, Wan-Yee, Patel, Akash J, Li, Xiao-Nan

“…Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus…”
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Long-term disease control and toxicity outcomes following surgery and intensity modulated radiation therapy (IMRT) in pediatric craniopharyngioma by Greenfield, Brad J, Okcu, Mehmet F, Baxter, Patricia A, Chintagumpala, Murali, Teh, Bin S, Dauser, Robert C, Su, Jack, Desai, Snehal S, Paulino, Arnold C

“…Abstract Purpose To report long-term progression-free survival (PFS) and late-toxicity outcomes in pediatric craniopharyngioma patients treated with IMRT…”
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Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma by Zhang, Huiyuan, Qi, Lin, Du, Yuchen, Huang, L. Frank, Braun, Frank K., Kogiso, Mari, Zhao, Yanling, Li, Can, Lindsay, Holly, Zhao, Sibo, Injac, Sarah G., Baxter, Patricia A., Su, Jack M., Stephan, Clifford, Keller, Charles, Heck, Kent A., Harmanci, Akdes, Harmanci, Arif O., Yang, Jianhua, Klisch, Tiemo J., Li, Xiao-Nan, Patel, Akash J.

“…Background. Meningiomas constitute one-third of all primary brain tumors. Although typically benign, about 20% of these tumors recur despite surgery and…”
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Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma by Kogiso, Mari, Qi, Lin, Du, Yuchen, Braun, Frank K., Zhang, Huiyuan, Huang, L. Frank, Guo, Lei, Huang, Yulun, Teo, Wan-Yee, Lindsay, Holly, Zhao, Sibo, Injac, Sarah G., Liu, Zhen, Mehta, Vidya, Tran, Diep, Li, Feng, Baxter, Patricia A., Su, Jack M., Perlaky, Laszlo, Parsons, D. Williams, Chintagumpala, Murali, Adesina, Adekunle, Song, Yongcheng, Li, Xiao-Nan

“…•A novel pair of orthotopic PDX models of glioma bearing IDH1-R132H/R132C mutations.•New mutant IDH1i (SY-435) with standard therapy led to strong therapeutic…”
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Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion by Merve, Ashirwad, Dubuc, Adrian M, Zhang, Xinyu, Remke, Marc, Baxter, Patricia A, Li, Xiao-Nan, Taylor, Michael D, Marino, Silvia

“…Medulloblastoma is the most common intracranial childhood malignancy and a genetically heterogeneous disease. Despite recent advances, current therapeutic…”
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A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study by Baxter, Patricia A, Su, Jack M, Onar-Thomas, Arzu, Billups, Catherine A, Li, Xiao-Nan, Poussaint, Tina Young, Smith, Edward R, Thompson, Patrick, Adesina, Adekunle, Ansell, Pete, Giranda, Vincent, Paulino, Arnold, Kilburn, Lindsey, Quaddoumi, Ibrahim, Broniscer, Alberto, Blaney, Susan M, Dunkel, Ira J, Fouladi, Maryam

“…Abstract Background A Pediatric Brain Tumor Consortium (PBTC) phase I/II trial of veliparib and radiation followed by veliparib and temozolomide (TMZ) was…”
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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial by Kilburn, Lindsay B., Khuong-Quang, Dong-Anh, Hansford, Jordan R., Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E. S., Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J., Ziegler, David S., Witt, Olaf, Baxter, Patricia A., Kang, Hyoung Jin, Hassall, Timothy E., Han, Jung Woo, Hargrave, Darren, Franson, Andrea T., Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S., Jabado, Nada, Gottardo, Nicholas G., Gerber, Nicolas U., Whipple, Nicholas S., Segal, Devorah, Chi, Susan N., Oren, Liat, Tan, Enrica E. K., Mueller, Sabine, Cornelio, Izzy, McLeod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C., Packer, Roger J., Nysom, Karsten

“…BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 ( n  = 77) of the ongoing phase 2 FIREFLY-1…”
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Overall survival and secondary malignant neoplasms in children receiving passively scattered proton or photon craniospinal irradiation for medulloblastoma by Paulino, Arnold C., Ludmir, Ethan B., Grosshans, David R., Su, Jack M., McGovern, Susan L., Okcu, M. Fatih, McAleer, Mary Frances, Baxter, Patricia A., Mahajan, Anita, Chintagumpala, Murali M.

“…BACKGROUND Both intensity‐modulated radiotherapy (RT) and passively scattered proton therapy have a risk of secondary malignant neoplasm (SMN) in children. To…”
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A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high‐grade glioma by Su, Jack Meng‐Fen, Murray, Jeffrey C., McNall‐Knapp, Rene Y., Bowers, Daniel C., Shah, Shafqat, Adesina, Adekunle M., Paulino, Arnold C., Jo, Eunji, Mo, Qianxing, Baxter, Patricia A., Blaney, Susan M.

“…Purpose To study the efficacy and tolerability of valproic acid (VPA) and radiation, followed by VPA and bevacizumab in children with newly diagnosed diffuse…”
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Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion by Sesen, Julie, Driscoll, Jessica, Shah, Nishali, Moses-Gardner, Alexander, Luiselli, Gabrielle, Alexandrescu, Sanda, Zurakowski, David, Baxter, Patricia A., Su, Jack M., Pricola Fehnel, Katie, Smith, Edward R.

“…[Display omitted] •Axon Guidance Factors are drivers of the invasive behavior of DIPG.•Neogenin is elevated in DIPG cells and patients.•Neogenin blockade…”
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Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies by Qi, Lin, Lindsay, Holly, Kogiso, Mari, Du, Yuchen, Braun, Frank K., Zhang, Huiyuan, Guo, Lei, Zhao, Sibo, Injac, Sarah G., Baxter, Patricia A., Su, Jack MF, Xiao, Sophie, Erickson, Stephen W., Earley, Eric J., Teicher, Beverly, Smith, Malcolm A., Li, Xiao-Nan

“…Brain tumors are the leading cause of cancer-related death in children. Tazemetostat is an FDA-approved enhancer of zeste homolog (EZH2) inhibitor. To…”
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Early radiotherapy preserves vision in sporadic optic pathway glioma by Hanania, Alexander N., Paulino, Arnold C., Ludmir, Ethan B., Shah, Veeral S., Su, Jack M., McGovern, Susan L., Baxter, Patricia A., McAleer, Mary Frances, Grosshans, David R., Okcu, M. Fatih, Chintagumpala, Murali M.

“…BACKGROUND Sporadic optic pathway/hypothalamic gliomas represent a unique entity within pediatric low‐grade glioma. Despite favorable survival, location makes…”
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A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study by DeWire, Mariko D, Fuller, Christine, Campagne, Olivia, Lin, Tong, Pan, Haitao, Young Poussaint, Tina, Baxter, Patricia A, Hwang, Eugene I, Bukowinski, Andrew, Dorris, Kathleen, Hoffman, Lindsey, Waanders, Angela J, Karajannis, Matthias A, Stewart, Clinton F, Onar-Thomas, Arzu, Fouladi, Maryam, Dunkel, Ira J

“…Genomic aberrations in cell cycle and PI3K pathways are commonly observed in pediatric brain tumors. This study determined the MTD/recommended phase II dose…”
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Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma by Rusert, Jessica M, Juarez, Edwin F, Brabetz, Sebastian, Jensen, James, Garancher, Alexandra, Chau, Lianne Q, Tacheva-Grigorova, Silvia K, Wahab, Sameerah, Udaka, Yoko T, Finlay, Darren, Seker-Cin, Huriye, Reardon, Brendan, Gröbner, Susanne, Serrano, Jonathan, Ecker, Jonas, Qi, Lin, Kogiso, Mari, Du, Yuchen, Baxter, Patricia A, Henderson, Jacob J, Berens, Michael E, Vuori, Kristiina, Milde, Till, Cho, Yoon-Jae, Li, Xiao-Nan, Olson, James M, Reyes, Iris, Snuderl, Matija, Wong, Terence C, Dimmock, David P, Nahas, Shareef A, Malicki, Denise, Crawford, John R, Levy, Michael L, Van Allen, Eliezer M, Pfister, Stefan M, Tamayo, Pablo, Kool, Marcel, Mesirov, Jill P, Wechsler-Reya, Robert J

“…Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ…”
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Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial by Kilburn, Lindsay B., Khuong-Quang, Dong-Anh, Hansford, Jordan R., Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E. S., Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J., Ziegler, David S., Witt, Olaf, Baxter, Patricia A., Kang, Hyoung Jin, Hassall, Timothy E., Han, Jung Woo, Hargrave, Darren, Franson, Andrea T., Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S., Jabado, Nada, Gottardo, Nicholas G., Gerber, Nicolas U., Whipple, Nicholas S., Segal, Devorah, Chi, Susan N., Oren, Liat, Tan, Enrica E. K., Mueller, Sabine, Cornelio, Izzy, McLeod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C., Packer, Roger J., Nysom, Karsten

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Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma by Liu, Zhigang, Zhao, Xiumei, Mao, Hua, Baxter, Patricia A, Huang, Yulun, Yu, Litian, Wadhwa, Lalita, Su, Jack M, Adesina, Adekunle, Perlaky, Lazlo, Hurwitz, Mary, Idamakanti, Neeraja, Police, Seshidhar Reddy, Hallenbeck, Paul L, Hurwitz, Richard L, Lau, Ching C, Chintagumpala, Murali, Blaney, Susan M, Li, Xiao-Nan

“…Seneca Valley virus (SVV-001) is a nonpathogenic oncolytic virus that can be systemically administered and can pass through the blood-brain barrier. We…”
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Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models by Kogiso, Mari, Qi, Lin, Braun, Frank K, Injac, Sarah G, Zhang, Linna, Du, Yuchen, Zhang, Huiyuan, Lin, Frank Y, Zhao, Sibo, Lindsay, Holly, Su, Jack M, Baxter, Patricia A, Adesina, Adekunle M, Liao, Debra, Qian, Mark G, Berg, Stacey, Muscal, Jodi A, Li, Xiao-Nan

“…Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of…”
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Gadolinium is not necessary for surveillance MR imaging in children with chiasmatic‐hypothalamic low‐grade glioma by Malbari, Fatema, Chintagumpala, Murali M., Wood, Alexis C., Levy, Adam S., Su, Jack M., Okcu, M. Fatih, Lin, Frank Y., Lindsay, Holly, Rednam, Surya P., Baxter, Patricia A., Paulino, Arnold C., Orzaiz, Guillermo Aldave, Whitehead, William E., Dauser, Robert, Supakul, Nucharin, Kralik, Stephen F.

“…Background Patients with chiasmatic‐hypothalamic low‐grade glioma (CHLGG) have frequent MRIs with gadolinium‐based contrast agents (GBCA) for disease…”
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Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma by Kogiso, Mari, Qi, Lin, Lindsay, Holly, Huang, Yulun, Zhao, Xiumei, Liu, Zhigang, Braun, Frank K, Du, Yuchen, Zhang, Huiyuan, Bae, Goeun, Zhao, Sibo, Injac, Sarah G, Sobieski, Mary, Brunell, David, Mehta, Vidya, Tran, Diep, Murray, Jeffrey, Baxter, Patricia A, Yuan, Xiao-Jun, Su, Jack M, Adesina, Adekunle, Perlaky, Laszlo, Chintagumpala, Murali, Parsons, D Williams, Lau, Ching C, Stephan, Clifford C, Lu, Xinyan, Li, Xiao-Nan

“…To identify cellular and molecular changes that driver pediatric low grade glioma (PLGG) progression, we analyzed putative cancer stem cells (CSCs) and…”
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A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo by Yu, Litian, Baxter, Patricia A, Voicu, Horatiu, Gurusiddappa, Sivashankarappa, Zhao, Yijue, Adesina, Adekunle, Man, Tsz-Kwong, Shu, Qin, Zhang, Yu-Jing, Zhao, Xiu-Mei, Su, Jack M, Perlaky, Lazlo, Dauser, Robert, Chintagumpala, Murali, Lau, Ching C, Blaney, Susan M, Rao, Pulivarthi H, Leung, Hon-Chiu Eastwood, Li, Xiao-Nan

“…Limited availability of in vitro and in vivo model systems has hampered efforts to understand tumor biology and test novel therapies for ependymoma, the third…”
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