Search Results - "Baxter, Gary F."

Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning by Ferdinandy, Peter, Schulz, Rainer, Baxter, Gary F

“…Therapeutic strategies to protect the ischemic myocardium have been studied extensively. Reperfusion is the definitive treatment for acute coronary syndromes,…”
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Nitric oxide treatments as adjuncts to reperfusion in acute myocardial infarction: a systematic review of experimental and clinical studies by Bice, Justin S., Jones, Bethan R., Chamberlain, Georgia R., Baxter, Gary F.

“…Unmodified reperfusion therapy for acute myocardial infarction (AMI) is associated with irreversible myocardial injury beyond that sustained during ischemia…”
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Regulation of cardiovascular cell function by hydrogen sulfide (H2S) by Elsey, David J, Fowkes, Robert C, Baxter, Gary F

“…Since the discovery of endogenously‐produced hydrogen sulfide (H2S) in various tissues, there has been an explosion of interest in H2S as a biological mediator…”
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Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium by Hamid, Shabaz A, Bower, Hugo S, Baxter, Gary F

“…Intracellular signal transduction events in reperfusion following ischemia influence myocardial infarct development. Here we investigate the role of Rho kinase…”
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Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia/reoxygenation by Gorbe, Aniko, Giricz, Zoltan, Szunyog, Andrea, Csont, Tamas, Burley, Dwaine S., Baxter, Gary F., Ferdinandy, Peter

“…Nitric oxide (NO) and B-type natriuretic peptide (BNP) are protective against ischemia–reperfusion injury as they increase intracellular cGMP level via…”
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Autocrine and paracrine actions of natriuretic peptides in the heart by D'Souza, Savio P, Davis, Martin, Baxter, Gary F

“…The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), are a family of polypeptide…”
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Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning by Ferdinandy, Péter, Hausenloy, Derek J, Heusch, Gerd, Baxter, Gary F, Schulz, Rainer

“…Pre-, post-, and remote conditioning of the myocardium are well described adaptive responses that markedly enhance the ability of the heart to withstand a…”
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Ischemic preconditioning is lost in aging hypertensive rat heart: Independent effects of aging and longstanding hypertension by Ebrahim, Zaileen, Yellon, Derek M., Baxter, Gary F.

“…Although in experimental hypertension the cardioprotective effects of ischemic preconditioning (PC) appear to be maintained, most studies have examined the…”
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B-type natriuretic peptide at early reperfusion limits infarct size in the rat isolated heart by Burley, Dwaine S, Baxter, Gary F

“…Natriuretic peptides are regulatory autacoids in the mammalian myocardium whose functions, mediated via particulate guanylyl cyclase/cGMP, may include…”
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Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes by Jonas, Kim C., Melrose, Timothy, Thompson, Iain R., Baxter, Gary F., Lipscomb, Victoria J., Niessen, Stijn J., Lawson, Charlotte, McArdle, Craig A., Roberson, Mark S., McGonnell, Imelda M., Wheeler-Jones, Caroline P., Fowkes, Robert C.

“…The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects…”
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Cardioprotective actions of peptide hormones in myocardial ischemia by Burley, Dwaine S, Hamid, Shabaz A, Baxter, Gary F

“…The myocardium represents a major source of several families of peptide hormones under normal physiological conditions and the plasma concentrations of many of…”
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The neutrophil as a mediator of myocardial ischemia-reperfusion injury: time to move on by Baxter, Gary F

“…Granulocytes, especially neutrophils, are recruited in myocardium during the evolution of acute myocardial infarction. Because the neutrophil reaction is most…”
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AP39, a mitochondria‐targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling by Karwi, Qutuba G, Bornbaum, Julia, Boengler, Kerstin, Torregrossa, Roberta, Whiteman, Matthew, Wood, Mark E, Schulz, Rainer, Baxter, Gary F

“…Background and Purpose H2S protects myocardium against ischaemia/reperfusion injury. This protection may involve the cytosolic reperfusion injury salvage…”
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Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning by Ferdinandy, Péter, Andreadou, Ioanna, Baxter, Gary F, Bøtker, Hans Erik, Davidson, Sean M, Dobrev, Dobromir, Gersh, Bernard J, Heusch, Gerd, Lecour, Sandrine, Ruiz-Meana, Marisol, Zuurbier, Coert J, Hausenloy, Derek J, Schulz, Rainer

“…Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the ability of the heart to withstand a prolonged ischemia/reperfusion…”
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Pre- and postconditioning the heart with hydrogen sulfide (H2S) against ischemia/reperfusion injury in vivo: a systematic review and meta-analysis by Karwi, Qutuba G., Bice, Justin S., Baxter, Gary F.

“…Conditioning-like infarct limitation by enhanced level of hydrogen sulfide (H 2 S) has been demonstrated in many animal models of myocardial…”
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A critical cytoprotective role of endogenous adrenomedullin in acute myocardial infarction by Hamid, Shabaz A., Baxter, Gary F.

“…Exogenous administration or transfection of adrenomedullin (AM) affords protection against ischaemia–reperfusion injury. Here we have examined the role of…”
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Renal ischemia preconditions myocardium: role of adenosine receptors and ATP-sensitive potassium channels by Pell, T J, Baxter, G F, Yellon, D M, Drew, G M

“…Brief renal ischemia-reperfusion is reported to precondition the myocardium; however, the underlying mechanisms are unknown. This phenomenon was, therefore,…”
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Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137 by Karwi, Qutuba G., Whiteman, Matthew, Wood, Mark E., Torregrossa, Roberta, Baxter, Gary F.

“…[Display omitted] Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present…”
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Adrenomedullin: regulator of systemic and cardiac homeostasis in acute myocardial infarction by Hamid, Shabaz A, Baxter, Gary F

“…During and following acute myocardial infarction, a variety of endogenous mediators are elevated, one of which is adrenomedullin (AM). AM is a multifunctional…”
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Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling by Andreadou, Ioanna, Daiber, Andreas, Baxter, Gary F., Brizzi, Maria Felice, Di Lisa, Fabio, Kaludercic, Nina, Lazou, Antigone, Varga, Zoltán V., Zuurbier, Coert J., Schulz, Rainer, Ferdinandy, Péter

“…The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic diseases such as obesity, hyperlipidemia, diabetes mellitus (DM),…”
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