Search Results - "Baxter, Douglas A."

How Can Memories Last for Days, Years, or a Lifetime? Proposed Mechanisms for Maintaining Synaptic Potentiation and Memory by Smolen, Paul, Baxter, Douglas A, Byrne, John H

“…With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a…”
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Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2 by Zhang, Yili, Smolen, Paul, Alberini, Cristina M., Baxter, Douglas A., Byrne, John H.

“…Key features of long-term memory (LTM), such as its stability and persistence, are acquired during processes collectively referred to as consolidation. The…”
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Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model by Smolen, Paul, Baxter, Douglas A, Byrne, John H

“…Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of…”
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Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation by Smolen, Paul, Baxter, Douglas A, Byrne, John H

“…A fundamental neuroscience question is how memories are maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term…”
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Computational design of enhanced learning protocols by Zhang, Yili, Liu, Rong-Yu, Heberton, George A, Smolen, Paul, Baxter, Douglas A, Cleary, Leonard J, Byrne, John H

“…The authors use computational modeling to design an optimized learning protocol that takes into account the precise timing of molecular signaling cascades that…”
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Molecular Mechanisms Underlying a Cellular Analog of Operant Reward Learning by Lorenzetti, Fred D., Baxter, Douglas A., Byrne, John H.

“…Operant conditioning is a ubiquitous but mechanistically poorly understood form of associative learning in which an animal learns the consequences of its…”
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Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia by Costa, Renan M., Baxter, Douglas A., Byrne, John H.

“…Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a…”
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Feeding Behavior of Aplysia: A Model System for Comparing Cellular Mechanisms of Classical and Operant Conditioning by Baxter, Douglas A, Byrne, John H

“…Feeding behavior of Aplysia provides an excellent model system for analyzing and comparing mechanisms underlying appetitive classical conditioning and reward…”
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Computational analyses of synergism in small molecular network motifs by Zhang, Yili, Smolen, Paul, Baxter, Douglas A, Byrne, John H

“…Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their…”
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A Reduced Model Clarifies the Role of Feedback Loops and Time Delays in the Drosophila Circadian Oscillator by Smolen, Paul, Baxter, Douglas A., Byrne, John H.

“…Although several detailed models of molecular processes essential for circadian oscillations have been developed, their complexity makes intuitive…”
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Voltage- and Calcium-Gated Membrane Currents Tune the Plateau Potential Properties of Multiple Neuron Types by Neveu, Curtis L, Smolen, Paul, Baxter, Douglas A, Byrne, John H

“…Many neurons exhibit regular firing that is limited to the duration and intensity of depolarizing stimuli. However, some neurons exhibit all-or-nothing plateau…”
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Computational Model of the Distributed Representation of Operant Reward Memory: Combinatoric Engagement of Intrinsic and Synaptic Plasticity Mechanisms by Costa, Renan M, Baxter, Douglas A, Byrne, John H

“…Operant reward learning of feeding behavior in "Aplysia" increases the frequency and regularity of biting, as well as biases buccal motor patterns (BMPs)…”
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Specific Plasticity Loci and Their Synergism Mediate Operant Conditioning by Momohara, Yuto, Neveu, Curtis L, Chen, Hsin-Mei, Baxter, Douglas A, Byrne, John H

“…Despite numerous studies examining the mechanisms of operant conditioning (OC), the diversity of OC plasticity loci and their synergism have not been examined…”
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Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal by Smolen, Paul, Baxter, Douglas A., Byrne, John H.

“…•Late LTP is not blocked when protein synthesis and degradation are inhibited together.•To investigate this paradox, we developed a minimal model describing…”
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Inferring neuronal network functional connectivity with directed information by Cai, Zhiting, Neveu, Curtis L, Baxter, Douglas A, Byrne, John H, Aazhang, Behnaam

“…A major challenge in neuroscience is to develop effective tools that infer the circuit connectivity from large-scale recordings of neuronal activity patterns…”
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Modeling suggests combined-drug treatments for disorders impairing synaptic plasticity via shared signaling pathways by Smolen, Paul, Wood, Marcelo A., Baxter, Douglas A., Byrne, John H.

“…Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning…”
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Computational Model of a Positive BDNF Feedback Loop in Hippocampal Neurons Following Inhibitory Avoidance Training by Zhang, Yili, Smolen, Paul, Alberini, Cristina M, Baxter, Douglas A, Byrne, John H

“…Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to…”
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Simulations suggest pharmacological methods for rescuing long-term potentiation by Smolen, Paul, Baxter, Douglas A., Byrne, John H.

“…Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie the induction or maintenance of synaptic plasticity. For…”
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Contribution of PKC to the maintenance of 5-HT-induced short-term facilitation at sensorimotor synapses of Aplysia by Zhou, Lian, Baxter, Douglas A, Byrne, John H

“…Aplysia sensorimotor synapses provide a useful model system for analyzing molecular processes that contribute to heterosynaptic plasticity. For example,…”
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Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning by Byrne, John H, Lorenzetti, Fred D, Mozzachiodi, Riccardo, Baxter, Douglas A

“…Learning can lead to changes in the intrinsic excitability of neurons. However, the extent to which these changes persist and the role they have in the…”
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