Search Results - "Baxevanis, C N"

Primary analysis of a prospective, randomized, single-blinded phase II trial evaluating the HER2 peptide AE37 vaccine in breast cancer patients to prevent recurrence by Mittendorf, E.A., Ardavanis, A., Symanowski, J., Murray, J.L., Shumway, N.M., Litton, J.K., Hale, D.F., Perez, S.A., Anastasopoulou, E.A., Pistamaltzian, N.F., Ponniah, S., Baxevanis, C.N., von Hofe, E., Papamichail, M., Peoples, G.E.

“…AE37 is the Ii-Key hybrid of the MHC class II peptide, AE36 (HER2 aa:776–790). Phase I studies showed AE37 administered with granulocyte macrophage…”
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Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope by SOTIRIADOU, R, PEREZ, S. A, PAPAMICHAIL, M, GRITZAPIS, A. D, SOTIROPOULOU, P. A, ECHNER, H, HEINZEL, S, MAMALAKI, A, PAWELEC, G, VOELTER, W, BAXEVANIS, C. N

“…HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly…”
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Cytotoxic T-cell precursor frequencies to HER-2 (369 - 377) in patients with HER-2 neu-positive epithelial tumours by SOTIROPOULOU, P. A, PEREZ, S. A, ILIOPOULOU, E. G, MISSITZIS, I, VOELTER, V, ECHNER, H, BAXEVANIS, C. N, PAPAMICHAIL, M

“…HER-2/neu oncoprotein contains several major histocompatibility complex class I-restricted epitopes, which are recognised by cytotoxic T lymphocyte (CTL) on…”
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Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients by Theodoropoulou, St, Spanakos, G., Baxevanis, C.N., Economou, M., Gritzapis, A.D., Papamichail, M.P., Stefanis, C.N.

“…A number of immunological parameters were studied in 82 DSM-III-R diagnosed schizophrenic patients (53 first drug-naive and 29 medicated chronic patients) as…”
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Pooled peptides from HER-2/neu-overexpressing primary ovarian tumours induce CTL with potent antitumour responses in vitro and in vivo by GRITZAPIS, A. D, PEREZ, S. A, BAXEVANIS, C. N, PAPAMICHAIL, M

“…Unfractionated peptides (MW: up to 10 kDa), derived from HLA-A2.1 positive (+) HER-2/neu-overexpressing primary tumour cell acid cell extracts (ACE), were…”
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Redirecting mouse T hybridoma against human breast and ovarian carcinomas: in vivo activity against HER-2/neu expressing cancer cells by GRITZAPIS, A. D, MAMALAKI, A, KRETSOVALI, A, PAPAMATHEAKIS, J, BELIMEZI, M, PEREZ, S. A, BAXEVANIS, C. N, PAPAMICHAIL, M

“…Chimeric receptors comprising of the T-cell receptor-zeta cytoplasmic signalling chain fused to an extracellular ligand-binding domain of a single-chain…”
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An improved fluorescence assay for the determination of lymphocyte-mediated cytotoxicity using flow cytometry by Papadopoulos, N G, Dedoussis, G V, Spanakos, G, Gritzapis, A D, Baxevanis, C N, Papamichail, M

“…The use of the chromium-release assay to determine cytotoxicity of effector against target cells has various limitations mostly due to the inherent properties…”
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Large-scale expansion of CD3+CD56+ lymphocytes capable of lysing autologous tumor cells with cytokine-rich supernatants by GRITZAPIS, A. D, DIMITROULOPOULOS, D, PARASKEVAS, E, BAXEVANIS, C. N, PAPAMICHAIL, M

“…We have developed culture conditions for the efficient expansion of cytotoxic effector cells from peripheral blood mononuclear cells (PBMC) by the timed…”
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Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer by Baxevanis, C N, Reclos, G J, Gritzapis, A D, Dedousis, G V, Missitzis, I, Papamichail, M

“…Human natural killer (NK) cells mediate spontaneous cytotoxicity against tumor cells and represent the main precursors of lymphokine-activated killer (LAK)…”
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Theophylline induces a reduction in circulating interleukin-4 and interleukin-5 in atopic asthmatics by Kosmas, EN, Michaelides, SA, Polychronaki, A, Roussou, T, Toukmatzi, S, Polychronopoulos, V, Baxevanis, CN

“…Theophylline, a known phosphodiesterase inhibitor, has been widely used as an additional bronchodilator in asthmatic patients who are not adequately controlled…”
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Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer by Baxevanis, C N, Dedoussis, G V, Papadopoulos, N G, Missitzis, I, Stathopoulos, G P, Papamichail, M

“…In vitro studies have demonstrated that exposure of tumor infiltrating lymphocytes (TIL) to human recombinant interleukin-2 (rIL-2) will generate activated…”
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Granulocyte-macrophage colony-stimulating factor improves immunological parameters in patients with refractory solid tumours receiving second-line chemotherapy: Correlation with clinical responses by Baxevanis, C.N, Tsavaris, N.B, Papadhimitriou, S.I, Zarkadis, I.K, Papadopoulos, N.G, Bastounis, E.A, Papamichail, M

“…In this report, we studied the immunorestorative properties of subcutaneously administered granulocyte-macrophage colony-stimulating factor (GM-CSF) in…”
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Daily variation in circulating cytokines and acute-phase proteins correlates with clinical and laboratory indices in community-acquired pneumonia by KOSMAS, E. N., BAXEVANIS, C. N., PAPAMICHAIL, M., KORDOSSIS, T.

“…Our objective was to investigate the initial levels of circulating proinflammatory cytokines, such as interleukin 1β (IL‐1β), interleukin 6 (IL‐6), and tumour…”
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Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation by Baxevanis, CN, Thanos, D, Reclos, GJ, Anastasopoulos, E, Tsokos, GC, Papamatheakis, J, Papamichail, M

“…Prothymosin alpha (ProT alpha) is an acidic polypeptide with potentiating effects on HLA-DR-restricted in vitro cellular immune response systems such as T cell…”
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Natural killer lymphocytes: biology, development, and function by PAPAMICHAIL, Michael, PEREZ, Sonia A, GRITZAPIS, Angelos D, BAXEVANIS, Constantin N

“…Natural killer (NK) lymphocytes represent the first line of defense against virally infected cells and tumor cells. The role of NK cells in immune responses…”
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Induction of anti-tumour lymphocytes in cancer patients after brief exposure to supernatants from cultures of anti-CD3-stimulated allogeneic lymphocytes by BAXEVANIS, C. N, TSIATAS, M. L, CACOULLOS, N. T, SPANAKOS, G, LIACOS, C, MISSITZIS, I, PAPADHIMITRIOU, S. I, PAPAMICHAIL, M

“…The present study investigated the ability of supernatants collected from cultures of healthy donor-derived peripheral blood mononuclear cells (HD-PBMCs)…”
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Increased generation of autologous tumor-reactive lymphocytes by anti-CD3 monoclonal antibody and prothymosin α by BAXEVANIS, C. N, SPANAKOS, G, VOUTSAS, I. F, GRITZAPIS, A. D, TSITSILONIS, O. E, MAMALAKI, A, PAPAMICHAIL, M

“…Anti-CD3 monoclonal antibody (mAb) activates in vitro peripheral blood mononuclear cells (PBMC) to lyse a variety of tumor cell lines in a non-major…”
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The prognostic value of alpha-thymosins in breast cancer by Tsitsilonis, O E, Bekris, E, Voutsas, I F, Baxevanis, C N, Markopoulos, C, Papadopoulou, S A, Kontzoglou, K, Stoeva, S, Gogas, J, Voelter, W, Papamichail, M

“…The prognosis of breast cancer is of major clinical importance and several histopathological, biochemical and immunological variables have been reported to be…”
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In Vivo Antitumor Activity of NKT Cells Activated by the Combination of IL-12 and IL-18 by Baxevanis, Constantin N, Gritzapis, Angelos D, Papamichail, Michael

“…Interleukin-12 and IL-18 have been demonstrated to potentiate innate immunity in a variety of experimental tumor models, but the functional roles of NK and/or…”
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Tumor-Specific CD4+ T Lymphocytes from Cancer Patients Are Required for Optimal Induction of Cytotoxic T Cells Against the Autologous Tumor by Baxevanis, Constantin N, Voutsas, Ioannis F, Tsitsilonis, Ourania E, Gritzapis, Angelos D, Sotiriadou, Roula, Papamichail, Michael

“…This study focuses on the specific CD4+ T cell requirement for optimal induction of cytotoxicity against MHC class II negative autologous tumors (AuTu)…”
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