Search Results - "Baxendale, Sarah"

Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data by Mendonca, Tania, Jones, Ana A, Pozo, Jose M, Baxendale, Sarah, Whitfield, Tanya T, Frangi, Alejandro F

“…A common feature of morphogenesis is the formation of three-dimensional structures from the folding of two-dimensional epithelial sheets, aided by cell shape…”
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The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model by Baxendale, Sarah, Asad, Anzar, Shahidan, Nahal O., Wiggin, Giselle R., Whitfield, Tanya T.

“…Summary Adhesion GPCRs are important regulators of conserved developmental processes and represent an untapped pool of potential targets for drug discovery…”
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Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures by Baxendale, Sarah, Holdsworth, Celia J, Meza Santoscoy, Paola L, Harrison, Michael R M, Fox, James, Parkin, Caroline A, Ingham, Philip W, Cunliffe, Vincent T

“…The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy. We…”
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Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression by Hartwell, Ryan D, England, Samantha J, Monk, Nicholas A M, van Hateren, Nicholas J, Baxendale, Sarah, Marzo, Mar, Lewis, Katharine E, Whitfield, Tanya T

“…In the zebrafish, Fgf and Hh signalling assign anterior and posterior identity, respectively, to the poles of the developing ear. Mis-expression of fgf3 or…”
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Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear by Jones, Ana A., Diamantopoulou, Elvira, Baxendale, Sarah, Whitfield, Tanya T.

“…Epithelial morphogenesis to form the semicircular canal ducts of the zebrafish inner ear depends on the production of the large glycosaminoglycan hyaluronan,…”
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Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection by Cheung, King Yee, Jesuthasan, Suresh J, Baxendale, Sarah, van Hateren, Nicholas J, Marzo, Mar, Hill, Christopher J, Whitfield, Tanya T

“…We report the presence of a rare cell type, the olfactory rod cell, in the developing zebrafish olfactory epithelium. These cells each bear a single actin-rich…”
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Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 ( gpr126 ) mutant by Diamantopoulou, Elvira, Baxendale, Sarah, de la Vega de León, Antonio, Asad, Anzar, Holdsworth, Celia J, Abbas, Leila, Gillet, Valerie J, Wiggin, Giselle R, Whitfield, Tanya T

“…Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish,…”
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Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity by Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, Goodyear, Richard J, Derudas, Marco, Cantillon, Daire M, Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N, Osgood, Richard T, Wilson, Charlotte Donald, Bull, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J, Richardson, Guy P

“…To identify small molecules that shield mammalian sensory hair cells from the ototoxic side effects of aminoglycoside antibiotics, 10,240 compounds were…”
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The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling by Ingham, Philip W, Baxendale, Sarah, Davison, Claire, Muxworthy, Claire, Wolff, Christian, Roy, Sudipto

“…Vertebrate skeletal muscles comprise distinct fiber types that differ in their morphology, contractile function, mitochondrial content and metabolic…”
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Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling by Hammond, Katherine L, Baxendale, Sarah, McCauley, David W, Ingham, Philip W, Whitfield, Tanya T

“…In the zebrafish embryo, expression of the prdm1 and patched1 genes in adaxial cells is indicative of their specification to give rise to slow twitch muscle…”
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Def‐2, ‐3, ‐6 and ‐8, novel mouse genes differentially expressed in the haemopoietic system by Hotfilder, Marc, Baxendale, Sarah, Cross, Michael A., Sablitzky, Fred

“…To identify developmentally regulated genes during myeloid differentiation, a self‐inactivating retroviral gene‐trap vector carrying a β‐galactosidase‐neomycin…”
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Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data by Tania Mendonca, Ana A. Jones, Jose M. Pozo, Sarah Baxendale, Tanya T. Whitfield, Alejandro F. Frangi

“…A common feature of morphogenesis is the formation of three-dimensional structures from the folding of two-dimensional epithelial sheets, aided by cell shape…”
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The Power of Zebrafish in Personalised Medicine by Baxendale, Sarah, van Eeden, Freek, Wilkinson, Robert

“…The goal of personalised medicine is to develop tailor-made therapies for patients in whom currently available therapeutics fail. This approach requires…”
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Clinical and preclinical therapeutic outcome metrics for USH2A-related disease by Toms, Maria, Dubis, Adam M, de Vrieze, Erik, Tracey-White, Dhani, Mitsios, Andreas, Hayes, Matthew, Broekman, Sanne, Baxendale, Sarah, Utoomprurkporn, Nattawan, Bamiou, Doris, Bitner-Glindzicz, Maria, Webster, Andrew R, Van Wijk, Erwin, Moosajee, Mariya

“…USH2A variants are the most common cause of Usher syndrome type 2, characterized by congenital sensorineural hearing loss and retinitis pigmentosa (RP), and…”
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A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B by Gurung, Ritika, Ono, Yosuke, Baxendale, Sarah, Lee, Samantha Lin Chiou, Moore, Steven, Calvert, Meredith, Ingham, Philip W

“…Myosin 18B is an unconventional myosin that has been implicated in tumor progression in humans. In addition, loss-of-function mutations of the MYO18B gene have…”
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A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo by Morsli, Samir, Henriques, Catarina M., Ellis, Pamela S., Mortiboys, Heather, Baxendale, Sarah, Loynes, Catherine A., Renshaw, Stephen A., Bellantuono, Ilaria

“…Senescence drives the onset and severity of multiple ageing‐associated diseases and frailty. As a result, there has been an increased interest in mechanistic…”
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Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin by Stooke-Vaughan, Georgina A, Obholzer, Nikolaus D, Baxendale, Sarah, Megason, Sean G, Whitfield, Tanya T

“…Otoliths are biomineralised structures important for balance and hearing in fish. Their counterparts in the mammalian inner ear, otoconia, have a primarily…”
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Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines by Crouzier, Lucie, Richard, Elodie M, Diez, Camille, Alzaeem, Hala, Denus, Morgane, Cubedo, Nicolas, Delaunay, Thomas, Glendenning, Emily, Baxendale, Sarah, Liévens, Jean-Charles, Whitfield, Tanya T, Maurice, Tangui, Delprat, Benjamin

“…Abstract Wolfram syndrome (WS) is a rare genetic disease characterized by diabetes, optic atrophy and deafness. Patients die at 35 years of age, mainly from…”
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Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene by Geng, Fan-Suo, Abbas, Leila, Baxendale, Sarah, Holdsworth, Celia J, Swanson, A George, Slanchev, Krasimir, Hammerschmidt, Matthias, Topczewski, Jacek, Whitfield, Tanya T

“…Morphogenesis of the semicircular canal ducts in the vertebrate inner ear is a dramatic example of epithelial remodelling in the embryo, and failure of normal…”
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A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos by Asad, Anzar, Shahidan, Nahal O, de la Vega de León, Antonio, Wiggin, Giselle R, Whitfield, Tanya T, Baxendale, Sarah

“…Adhesion G protein-coupled receptors (GPCRs) are an underrepresented class of GPCRs in drug discovery. We previously developed an in vivo drug screening…”
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