Spring and parachute: How cocrystals enhance solubility

This article is intended to combine literature on cocrystallization – a tool for enhancing the solubility and for improving the physicochemical properties of an API (an API is the molecule which is responsible for providing the therapeutic effect) with special emphasis on the mechanism responsible f...

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Bibliographic Details
Published in:	Progress in crystal growth and characterization of materials Vol. 62; no. 3; pp. 1 - 8
Main Authors:	Bavishi, Dhara D., Borkhataria, Chetan H.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-09-2016
Subjects:	Cocrystallization Cocrystals Covalent bonds Crystal growth Crystals Drugs Pharmaceuticals Poorly soluble drugs Solubility Spring-parachute phenomena Poorly soluble drugs Spring-parachute phenomena Cocrystals Solubility
Online Access:	Get full text
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Summary:	This article is intended to combine literature on cocrystallization – a tool for enhancing the solubility and for improving the physicochemical properties of an API (an API is the molecule which is responsible for providing the therapeutic effect) with special emphasis on the mechanism responsible for the same. The pharmaceutical industries are witnessing a developing crisis in the process of drug development due to the increasing cost of their R&D departments, the failure of some blockbuster drug candidates exhibiting poor aqueous solubility and the unavailability of newer molecules because of patent limitations. Cocrystallization is an emerging approach to improve solubility, dissolution profile, bioavailability, and other physicochemical and mechanical properties of an API. A pharmaceutical cocrystal is now a new epitome which enables the use of a wide range of active pharmaceutical ingredients without the need to form or break the covalent bonds. The prime focus of this review article is the mechanism on how cocrystals have a solubility advantage over the amorphous form. This review also provides a brief introduction to the nature of cocrystals, their role, principles of crystal engineering and also highlights the nature of supramolecular synthons which are present in cocrystals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-8974 1878-4208
DOI:	10.1016/j.pcrysgrow.2016.07.001