Search Results - "Bausch, Christoph"

A fully human monoclonal antibody possesses antibody‐dependent cellular cytotoxicity (ADCC) activity against the H1 subtype of influenza A virus by targeting a conserved epitope at the HA1 protomer interface by Gao, Rongyuan, Wang, Zhao, Uprety, Tirth, Sreenivasan, Chithra C., Sheng, Zizhang, Hause, Ben M., Brunick, Colin, Wu, Hua, Luke, Thomas, Bausch, Christoph L., Sullivan, Eddie J., Hoppe, Adam D., Huber, Victor C., Wang, Dan, Li, Feng

“…The DiversitabTM system produces target specific high titer fully human polyclonal IgG immunoglobulins from transchromosomic (Tc) bovines shown to be safe and…”
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Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019 by Tang, Juanjie, Grubbs, Gabrielle, Lee, Youri, Wu, Hua, Luke, Thomas C, Egland, Kristi A, Bausch, Christoph L, Sullivan, Eddie J, Khurana, Surender

“…Abstract Passive antibody immunotherapeutics directed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are promising countermeasures for…”
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Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain by Gao, Rongyuan, Sreenivasan, Chithra C, Sheng, Zizhang, Hause, Ben M, Zhou, Bin, Wentworth, David E, Clement, Travis, Rausch, Dana, Brunick, Colin, Christopher-Hennings, Jane, Wu, Hua, Bausch, Christoph L, Sullivan, Eddie J, Hoppe, Adam D, Huber, Victor C, Wang, Dan, Li, Feng

“…Influenza remains a global health risk and challenge. Currently, neuraminidase (NA) inhibitors are extensively used to treat influenza, but their efficacy is…”
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Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants by Liu, Zhuoming, Wu, Hua, Egland, Kristi A., Gilliland, Theron C., Dunn, Matthew D., Luke, Thomas C., Sullivan, Eddie J., Klimstra, William B., Bausch, Christoph L., Whelan, Sean P. J.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with amino-acid substitutions and deletions in spike protein (S) can reduce the…”
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Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source by Brocato, Rebecca L, Wu, Hua, Kwilas, Steven A, Principe, Lucia M, Josleyn, Matthew, Shamblin, Joshua, Chivukula, Padmanabh, Bausch, Christoph, Luke, Thomas, Sullivan, Eddie J, Hooper, Jay W

“…Hantaviruses are rodent-borne viruses that cause severe disease in infected humans. In the New World, major hantaviruses include Andes virus (ANDV) and Sin…”
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Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models by Perley, Casey C., Brocato, Rebecca L., Wu, Hua, Bausch, Christoph, Karmali, Priya P., Vega, Jerel B., Cohen, Melanie V., Somerville, Brandon, Kwilas, Steven A., Principe, Lucia M., Shamblin, Joshua, Chivukula, Padmanabh, Sullivan, Eddie, Hooper, Jay W.

“…We explored an emerging technology to produce anti-Hantaan virus (HTNV) and anti-Puumala virus (PUUV) neutralizing antibodies for use as pre- or post-exposure…”
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Polyclonal Antibodies Derived from Transchromosomic Bovines Vaccinated with the Recombinant F1-V Vaccine Increase Bacterial Opsonization In Vitro and Protect Mice from Pneumonic Plague by Biryukov, Sergei S, Wu, Hua, Dankmeyer, Jennifer L, Rill, Nathaniel O, Klimko, Christopher P, Egland, Kristi A, Shoe, Jennifer L, Hunter, Melissa, Fetterer, David P, Qiu, Ju, Davies, Michael L, Bausch, Christoph L, Sullivan, Eddie J, Luke, Thomas, Cote, Christopher K

“…Plague is an ancient disease that continues to be of concern to both the public health and biodefense research communities. Pneumonic plague is caused by…”
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Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants by Gilliland, Theron, Dunn, Matthew, Liu, Yanan, Alcorn, Maria D.H., Terada, Yutaka, Vasilatos, Shauna, Lundy, Jeneveve, Li, Rong, Nambulli, Sham, Larson, Deanna, Duprex, Paul, Wu, Hua, Luke, Thomas, Bausch, Christoph, Egland, Kristi, Sullivan, Eddie, Wang, Zhongde, Klimstra, William B.

“…Pandemic SARS-CoV-2 has undergone rapid evolution resulting in the emergence of many variants with mutations in the spike protein, some of which appear to…”
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Transcription Alters Chromosomal Locations of Cohesin in Saccharomyces cerevisiae by Bausch, Christoph, Noone, Seth, Henry, Jill M., Gaudenz, Karin, Sanderson, Brian, Seidel, Chris, Gerton, Jennifer L.

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Transcriptional Organization and Regulation of the l-Idonic Acid Pathway (GntII System) in Escherichia coli by BAUSCH, Christoph, RAMSEY, Matthew, CONWAY, Tyrrell

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Sequence Analysis of the GntII (Subsidiary) System for Gluconate Metabolism Reveals a Novel Pathway for l-Idonic Acid Catabolism in Escherichia coli by Bausch, C, Peekhaus, N, Utz, C, Blais, T, Murray, E, Lowary, T, Conway, T

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885-P: IND-Enabling Assessment of Tolerance and Safety for SAB-142-A First-in-Class Fully Human Polyclonal Antithymocyte Immunoglobulin to Delay the Progression of Type 1 Diabetes by Egland, Kristi A, Maher, Diane, Sandhurst, Eric S, Wu, Hua, Savinov, Alexei Y, Ezzelarab, Mohamed, Bausch, Christoph L, Luke, Thomas C

“…SAB-142, a human polyclonal anti-thymocyte immunoglobulin, is currently being evaluated for safety in a Phase 1 clinical trial for Type 1 Diabetes (T1D)…”
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Deciphering the Mechanisms of Therapeutic Protein Production by Allison, Daniel W, Borgschulte, Trissa, Bausch, Christoph L, Bahr, Scott M, Caple, Matthew V, Kayser, Kevin J

“…Using this database, we have designed a CHO microarray to identify changes to the transcriptome in various CHO clones. Our current CHO microarray design…”
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Safety and Efficacy of SAB-185 for Nonhospitalized Adults With COVID-19: A Randomized Clinical Trial by Chew, Kara W, Taiwo, Babafemi O, Moser, Carlee, Daar, Eric S, Wohl, David Alain, Ritz, Justin, Javan, Arzhang Cyrus, Li, Jonathan Z, Fischer, William, Greninger, Alexander L, Bausch, Christoph, Luke, Thomas, Call, Robert, Neytman, Gene, Giganti, Mark J, Fletcher, Courtney V, Hughes, Michael D, Eron, Joseph J, Currier, Judith S, Smith, Davey M, Chew, Kara, Smith, David (Davey), Daar, Eric, Wohl, David, Currier, Judith, Eron, Joseph, Javan, Arzhang Cyrus, Hughes, Michael, Moser, Carlee, Giganti, Mark, Ritz, Justin, Hosey, Lara, Roa, Jhoanna, Patel, Nilam, Colsh, Kelly, Rwakazina, Irene, Beck, Justine, Sieg, Scott, Li, Jonathan, Fletcher, Courtney, Fischer, William, Evering, Teresa, Ignacio, Rachel Bender, Cardoso, Sandra, Corado, Katya, Jagannathan, Prasanna, Jilg, Nikolaus, Perelson, Alan, Pillay, Sandy, Riviere, Cynthia, Singh, Upinder, Taiwo, Babafemi, Gottesman, Joan, Newell, Matthew, Pedersen, Susan, Dragavon, Joan, Jennings, Cheryl, Greenfelder, Brian, Murtaugh, William, Kosmyna, Jan, Gapara, Morgan, Shahkolahi, Akbar

“…Abstract Background We evaluated the fully human polyclonal antibody product SAB-185 in a phase 3 trial for COVID-19. Methods Nonhospitalized high-risk adults…”
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Phase 2 Safety and Antiviral Activity of SAB-185, a Novel Polyclonal Antibody Therapy for Nonhospitalized Adults With COVID-19 by Taiwo, Babafemi O, Chew, Kara W, Moser, Carlee, Wohl, David Alain, Daar, Eric S, Li, Jonathan Z, Greninger, Alexander L, Bausch, Christoph, Luke, Thomas, Hoover, Keila, Neytman, Gene, Giganti, Mark J, Olefsky, Maxine, Javan, Arzhang Cyrus, Fletcher, Courtney V, Eron, Joseph J, Currier, Judith S, Hughes, Michael D, Smith, Davey M

“…In this phase 2 evaluation of SAB-185 in the ACTIV-2/ACTG A5401 platform trial of investigational agents for outpatient COVID-19 treatment, this…”
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Safety and Efficacy of SAB-185 for Non-hospitalized Adults with COVID-19: A Randomized Clinical Trial by Chew, Kara W, Taiwo, Babafemi O, Moser, Carlee, Daar, Eric S, Wohl, David Alain, Ritz, Justin, Javan, Arzhang Cyrus, Li, Jonathan Z, Fischer, William, Greninger, Alexander L, Bausch, Christoph, Luke, Thomas, Call, Robert, Neytman, Gene, Giganti, Mark J, Fletcher, Courtney V, Hughes, Michael D, Eron, Joseph J, Currier, Judith S, Smith, Davey M

“…To address the need for novel COVID-19 therapies, we evaluated the fully-human polyclonal antibody product SAB-185 in a phase 3 clinical trial…”
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Increased antibody avidity and cross-neutralization of SARS-CoV-2 variants by hyperimmunized Tc-Bovine derived human immunoglobulins for treatment of COVID-19 by Tang, Juanjie, Grubbs, Gabrielle, Lee, Youri, Wu, Hua, Luke, Thomas C, Egland, Kristi A, Bausch, Christoph L, Sullivan, Eddie J, Khurana, Surender

“…Passive antibody immunotherapeutics directed against SARS-CoV-2 are promising countermeasures for protection and treatment of COVID-19. SARS-CoV-2 Variants of…”
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Functional genomics: expression analysis of Escherichia coli growing on minimal and rich media by Tao, H, Bausch, C, Richmond, C, Blattner, F R, Conway, T

“…DNA arrays of the entire set of Escherichia coli genes were used to measure the genomic expression patterns of cells growing in late logarithmic phase on…”
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The L-idonic acid pathway of Escherichia coli by Bausch, Christoph Lawrence

“…Early studies of D-gluconate catabolism in Escherichia coli revealed two similar systems thought to be involved with gluconate catabolism. The main system,…”
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Molecular genetic characterization of the Escherichia coli gntT gene of GntI, the main system for gluconate metabolism by Porco, A, Peekhaus, N, Bausch, C, Tong, S, Isturiz, T, Conway, T

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