Search Results - "Baur, Wendy"

A Smooth Muscle-Like Origin for Beige Adipocytes by Long, Jonathan Z., Svensson, Katrin J., Tsai, Linus, Zeng, Xing, Roh, Hyun C., Kong, Xingxing, Rao, Rajesh R., Lou, Jesse, Lokurkar, Isha, Baur, Wendy, Castellot, John J., Rosen, Evan D., Spiegelman, Bruce M.

“…Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure…”
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Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3 by Qin, Zhexue, Bagley, Jessamyn, Sukhova, Galina, Baur, Wendy E, Park, Ho-Jin, Beasley, Debbie, Libby, Peter, Zhang, Yali, Galper, Jonas B

“…Abstract Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE−/− )…”
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ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells by Wang, Yuepeng, Zheng, Xiaoyu Rayne, Riddick, Nadeene, Bryden, Meredith, Baur, Wendy, Zhang, Xin, Surks, Howard K

“…Abnormal vascular smooth muscle cell (VSMC) contraction plays an important role in vascular diseases. The RhoA/ROCK signaling pathway is now well recognized to…”
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MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation by Zhao, Jin, Schnitzler, Gavin R, Iyer, Lakshmanan K, Aronovitz, Mark J, Baur, Wendy E, Karas, Richard H

“…MicroRNA-offset RNAs (moRs) were first identified in simple chordates and subsequently in mouse and human cells by deep sequencing of short RNAs. MoRs are…”
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Rapid Estrogen Receptor Signaling Is Essential for the Protective Effects of Estrogen Against Vascular Injury by BERNELOT MOENS, Sophie J, SCHNITZLER, Gavin R, IYER, Lakshmanan K, KARAS, Richard H, NICKERSON, Moriah, HUIMING GUO, UEDA, Kazutaka, QING LU, ARONOVITZ, Mark J, NICKERSON, Heather, BAUR, Wendy E, HANSEN, Ulla

“…Clinical trial and epidemiological data support that the cardiovascular effects of estrogen are complex, including a mixture of both potentially beneficial and…”
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Rapid Estrogen Receptor Signaling Mediates Estrogen-Induced Inhibition of Vascular Smooth Muscle Cell Proliferation by Ueda, Kazutaka, Lu, Qing, Baur, Wendy, Aronovitz, Mark J, Karas, Richard H

“…OBJECTIVE—The proliferation of vascular smooth muscle cells (VSMCs) plays a crucial role in vascular diseases, such as atherosclerosis and restenosis, after…”
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Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion by Caprio, Massimiliano, Newfell, Brenna G, la Sala, Andrea, Baur, Wendy, Fabbri, Andrea, Rosano, Giuseppe, Mendelsohn, Michael E, Jaffe, Iris Z

“…In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by unknown mechanisms. The steroid hormone aldosterone acts by…”
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Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload by Calamaras, Timothy D, Baumgartner, Robert A, Aronovitz, Mark J, McLaughlin, Angela L, Tam, Kelly, Richards, Daniel A, Cooper, Craig W, Li, Nathan, Baur, Wendy E, Qiao, Xiaoying, Wang, Guang-Rong, Davis, Roger J, Kapur, Navin K, Karas, Richard H, Blanton, Robert M

“…Myocardial hypertrophy is an independent risk factor for heart failure (HF), yet the mechanisms underlying pathological cardiomyocyte growth are incompletely…”
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Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A by Ueda, Kazutaka, Takimoto, Eiki, Lu, Qing, Liu, Pangyen, Fukuma, Nobuaki, Adachi, Yusuke, Suzuki, Ryo, Chou, Shengpu, Baur, Wendy, Aronovitz, Mark J, Greenberg, Andrew S, Komuro, Issei, Karas, Richard H

“…Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the…”
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Striatin Assembles a Membrane Signaling Complex Necessary for Rapid, Nongenomic Activation of Endothelial NO Synthase by Estrogen Receptor α by Lu, Qing, Pallas, David C., Surks, Howard K., Baur, Wendy E., Mendelsohn, Michael E., Karas, Richard H., Housman, David E.

“…Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate gene expression. SHRs also mediate rapid, nongenomic cellular…”
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Estrogen Receptor–Mediated Regulation of MicroRNA Inhibits Proliferation of Vascular Smooth Muscle Cells by Zhao, Jin, Imbrie, Gregory A, Baur, Wendy E, Iyer, Lakshmanan K, Aronovitz, Mark J, Kershaw, Tanya B, Haselmann, Greta M, Lu, Qing, Karas, Richard H

“…OBJECTIVE—Estradiol (E2) regulates gene transcription by activating estrogen receptor-α and estrogen receptor-β. Many of the genes regulated by E2 via estrogen…”
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Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging by DuPont, Jennifer J, McCurley, Amy, Davel, Ana P, McCarthy, Joseph, Bender, Shawn B, Hong, Kwangseok, Yang, Yan, Yoo, Jeung-Ki, Aronovitz, Mark, Baur, Wendy E, Christou, Demetra D, Hill, Michael A, Jaffe, Iris Z

“…Hypertension is nearly universal yet poorly controlled in the elderly despite proven benefits of intensive treatment. Mice lacking mineralocorticoid receptors…”
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High blood pressure arising from a defect in vascular function by Michael, Simon K, Surks, Howard K, Wang, Yuepeng, Zhu, Yan, Blanton, Robert, Jamnongjit, Michelle, Aronovitz, Mark, Baur, Wendy, Ohtani, Kenichi, Wilkerson, Michael K, Bonev, Adrian D, Nelson, Mark T, Karas, Richard H, Mendelsohn, Michael E

“…Hypertension, a major cardiovascular risk factor and cause of mortality worldwide, is thought to arise from primary renal abnormalities. However, the etiology…”
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A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML by Gopal, Srila, Lu, Qing, Man, Joshua J., Baur, Wendy, Rao, Sitara P., Litichevskiy, Lev, Papanastasiou, Malvina, Creech, Amanda L., DeRuff, Katherine C., Mullahoo, James, Officer, Adam, Egri, Shawn B., Davison, Desiree, Jaffe, Jacob D., Jaffe, Iris Z.

“…•Newer CML kinase inhibitors increase ischemia risk and are toxic to endothelial cells where they produce a proteomic toxicity signature.•This phosphoproteomic…”
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MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor α by Lu, Qing, Ebling, Heather, Mittler, Jens, Baur, Wendy E, Karas, Richard H

“…In addition to mediating the classical transcriptional effects of estrogen, estrogen receptors (ERs) are now known to regulate gene expression in the absence…”
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Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A by Lu, Qing, Surks, Howard K, Ebling, Heather, Baur, Wendy E, Brown, Donald, Pallas, David C, Karas, Richard H

“…Estrogen receptor alpha (ERalpha) mediates the effects of estrogen by altering gene expression following hormone binding. It has recently been shown that…”
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Endothelial progenitor cells delivered into the pericardial space incorporate into areas of ischemic myocardium by Saltzman, Adam J, Choi, Sung W, Dabreo, Alexandra, Baur, Wendy E, Weiss, Eric, Nguyen, Khan, Ishibashi, Fumiyuki, Celestin, Flore F, Karia, Darshak H, Pandian, Natesa G, Karas, Richard H, Waxman, Sergio

“…Abstract Objective Our objective was to determine whether autologous endothelial progenitor cells (EPCs) delivered into the pericardial space will migrate to…”
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The Mineralocorticoid Receptor in Myeloid Cells Promotes Vascular Inflammation and Atherosclerosis via Transcriptional Regulation of Selplg by Man, Joshua, Lu, Qing, Moss, M., Carvajal, Brigett, Baur, Wendy, Alcaide, Pilar, Jaffe, Iris

“…Elevated plasma aldosterone (Aldo) is associated with increased risk of cardiovascular (CV) ischemia, and inhibition of the Aldo‐activated mineralocorticoid…”
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Sex differences in the role of the vascular angiotensin II receptors in vascular aging by DuPont, Jennifer J., Kenney, Rachel M., Kim, Seung K., Baur, Wendy, Lu, Qing, Martin, Gregory, Pulakat, Lakshmi

“…Abstract only Background Aged women have greater vascular stiffness and vasomotor dysfunction vs. aged men, leading to a greater incidence of cardiovascular…”
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Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis by Man, Joshua J., Lu, Qing, Moss, M. Elizabeth, Carvajal, Brigett, Baur, Wendy, Garza, Amanda E., Freeman, Roy, Anastasiou, Marina, Ngwenyama, Njabulo, Adler, Gail K., Alcaide, Pilar, Jaffe, Iris Z.

“…MR (mineralocorticoid receptor) activation associates with increased risk of cardiovascular ischemia while MR inhibition reduces cardiovascular-related…”
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