Search Results - "Baumlova, Adriana"

Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein by Klima, Martin, Tóth, Dániel J., Hexnerova, Rozalie, Baumlova, Adriana, Chalupska, Dominika, Tykvart, Jan, Rezabkova, Lenka, Sengupta, Nivedita, Man, Petr, Dubankova, Anna, Humpolickova, Jana, Nencka, Radim, Veverka, Vaclav, Balla, Tamas, Boura, Evzen

“…Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential…”
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A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha[S] by Sengupta, Nivedita, Jović, Marko, Barnaeva, Elena, Kim, David W., Hu, Xin, Southall, Noel, Dejmek, Milan, Mejdrova, Ivana, Nencka, Radim, Baumlova, Adriana, Chalupska, Dominika, Boura, Evzen, Ferrer, Marc, Marugan, Juan, Balla, Tamas

“…The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different…”
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Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4‑Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology by Mejdrová, Ivana, Chalupská, Dominika, Plačková, Pavla, Müller, Christin, Šála, Michal, Klíma, Martin, Baumlová, Adriana, Hřebabecký, Hubert, Procházková, Eliška, Dejmek, Milan, Strunin, Dmytro, Weber, Jan, Lee, Gary, Matoušová, Marika, Mertlíková-Kaiserová, Helena, Ziebuhr, John, Birkus, Gabriel, Boura, Evzen, Nencka, Radim

“…Phosphatidylinositol 4-kinase IIIβ (PI4KB) is indispensable for the replication of various positive-sense single stranded RNA viruses, which hijack this…”
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Highly Selective Phosphatidylinositol 4‑Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action by Mejdrová, Ivana, Chalupská, Dominika, Kögler, Martin, Šála, Michal, Plačková, Pavla, Baumlová, Adriana, Hřebabecký, Hubert, Procházková, Eliška, Dejmek, Milan, Guillon, Rémi, Strunin, Dmytro, Weber, Jan, Lee, Gary, Birkus, Gabriel, Mertlíková-Kaiserová, Helena, Boura, Evzen, Nencka, Radim

“…Phosphatidylinositol 4-kinase IIIβ is a cellular lipid kinase pivotal to pathogenesis of various RNA viruses. These viruses hijack the enzyme in order to…”
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Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein by Klima, Martin, Chalupska, Dominika, Różycki, Bartosz, Humpolickova, Jana, Rezabkova, Lenka, Silhan, Jan, Baumlova, Adriana, Dubankova, Anna, Boura, Evzen

“…Picornaviruses are small positive-sense single-stranded RNA viruses that include many important human pathogens. Within the host cell, they replicate at…”
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Metal ions‐binding T4 lysozyme as an intramolecular protein purification tag compatible with X‐ray crystallography by Boura, Evzen, Baumlova, Adriana, Chalupska, Dominika, Dubankova, Anna, Klima, Martin

“…Phage T4 lysozyme is a well folded and highly soluble protein that is widely used as an insertion tag to improve solubility and crystallization properties of…”
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The crystal structure of the phosphatidylinositol 4-kinase IIα by Baumlova, Adriana, Chalupska, Dominika, Róźycki, Bartosz, Jovic, Marko, Wisniewski, Eva, Klima, Martin, Dubankova, Anna, Kloer, Daniel P, Nencka, Radim, Balla, Tamas, Boura, Evzen

“…Phosphoinositides are a class of phospholipids generated by the action of phosphoinositide kinases with key regulatory functions in eukaryotic cells. Here, we…”
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The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design by Klima, Martin, Baumlova, Adriana, Chalupska, Dominika, Hřebabecký, Hubert, Dejmek, Milan, Nencka, Radim, Boura, Evzen

“…Phosphatidylinositol 4‐phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4‐kinases (PI4Ks)…”
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Finding Inhibitors for The Type II Phosphatidylinositol 4‐kinase Alpha Enzyme by SENGUPTA, NIVEDITA, JOVIC, MARKO, BARNAEVA, ELENA, Baumlova, Adriana, Southall, Noel, Hu, Xin, Marugan, Juan, Ferrer, Marc, Boura, Evzen, Balla, Tamas

“…Abstract only Type II phosphatidylinositol 4‐kinases (PI4K2A and 2B) are two of four lipid kinases that synthesize phosphatidylinositol 4‐phosphate (PI4P) in…”
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The crystal structure of the phosphatidylinositol 4-kinase II[alpha] by Baumlova, Adriana, Chalupska, Dominika, Roycki, Bartosz, Jovic, Marko, Wisniewski, Eva, Klima, Martin, Dubankova, Anna, Kloer, Daniel P, Nencka, Radim, Balla, Tamas, Boura, Evzen

“…Phosphoinositides are a class of phospholipids generated by the action of phosphoinositide kinases with key regulatory functions in eukaryotic cells. Here, we…”
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The high-resolution crystal structure of phosphatidylinositol 4-kinase II[beta] and the crystal structure of phosphatidylinositol 4-kinase II[alpha] containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design by Klima, Martin, Baumlova, Adriana, Chalupska, Dominika, Hrebabecky, Hubert, Dejmek, Milan, Nencka, Radim, Boura, Evzen

“…Phosphatidylinositol 4-phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4-kinases (PI4Ks)…”
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