Search Results - "Baumgrass, Ria"

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? by Sieber, Matthias, Baumgrass, Ria

“…The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for…”
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Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception by Gryzik, Stefanie, Hoang, Yen, Lischke, Timo, Mohr, Elodie, Venzke, Melanie, Kadner, Isabelle, Poetzsch, Josephine, Groth, Detlef, Radbruch, Andreas, Hutloff, Andreas, Baumgrass, Ria

“…Dysregulated cytokine expression by T cells plays a pivotal role in the pathogenesis of autoimmune diseases. However, the identification of the corresponding…”
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Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model by Fuhrmann, Franziska, Lischke, Timo, Gross, Fridolin, Scheel, Tobias, Bauer, Laura, Kalim, Khalid Wasim, Radbruch, Andreas, Herzel, Hanspeter, Hutloff, Andreas, Baumgrass, Ria

“…The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen…”
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PRI: Re-Analysis of a Public Mass Cytometry Dataset Reveals Patterns of Effective Tumor Treatments by Hoang, Yen, Gryzik, Stefanie, Hoppe, Ines, Rybak, Alexander, Schädlich, Martin, Kadner, Isabelle, Walther, Dirk, Vera, Julio, Radbruch, Andreas, Groth, Detlef, Baumgart, Sabine, Baumgrass, Ria

“…Recently, mass cytometry has enabled quantification of up to 50 parameters for millions of cells per sample. It remains a challenge to analyze such…”
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Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells by Nürnberg, Christina, Kociok, Norbert, Brockmann, Claudia, Lischke, Timo, Crespo-Garcia, Sergio, Reichhart, Nadine, Wolf, Susanne, Baumgrass, Ria, Eming, Sabine A., Beer-Hammer, Sandra, Joussen, Antonia M.

“…Anti-VEGF-directed therapies have been a milestone for treating retinal vascular diseases. Depletion of monocyte lineage cells suppresses pathological…”
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Identification of a New and Effective Marker Combination for a Standardized and Automated Bin-Based Basophil Activation Test (BAT) Analysis by Groffmann, Johannes, Hoppe, Ines, Ahmed, Wail Abbas Nasser, Hoang, Yen, Gryzik, Stefanie, Radbruch, Andreas, Worm, Margitta, Beyer, Kirsten, Baumgrass, Ria

“…(1) Background: The basophil activation test (BAT) is a functional whole blood-based ex vivo assay to quantify basophil activation after allergen exposure by…”
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Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression by Podtschaske, Miriam, Benary, Uwe, Zwinger, Sandra, Höfer, Thomas, Radbruch, Andreas, Baumgrass, Ria

“…The expression of interleukin-2 (IL-2) is a key event in T helper (Th) lymphocyte activation, controlling both, the expansion and differentiation of effector…”
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Autoregulation of Th1-mediated inflammation by twist1 by Niesner, Uwe, Albrecht, Inka, Janke, Marko, Doebis, Cornelia, Loddenkemper, Christoph, Lexberg, Maria H, Eulenburg, Katharina, Kreher, Stephan, Koeck, Juliana, Baumgrass, Ria, Bonhagen, Kerstin, Kamradt, Thomas, Enghard, Philipp, Humrich, Jens Y, Rutz, Sascha, Schulze-Topphoff, Ulf, Aktas, Orhan, Bartfeld, Sina, Radbruch, Helena, Hegazy, Ahmed N, Löhning, Max, Baumgart, Daniel C, Duchmann, Rainer, Rudwaleit, Martin, Häupl, Thomas, Gitelman, Inna, Krenn, Veit, Gruen, Joachim, Sieper, Jochen, Zeitz, Martin, Wiedenmann, Bertram, Zipp, Frauke, Hamann, Alf, Janitz, Michal, Scheffold, Alexander, Burmester, Gerd R, Chang, Hyun D, Radbruch, Andreas

“…The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is involved…”
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Low-dose, but not high-dose, cyclosporin A promotes regulatory T-cell induction, expansion, or both by Baumgrass, Ria, PhD, Brandt, Claudia, MSc, Wegner, Fanny, BSc, Abdollahnia, Mandana, MD, Worm, Margitta, MD

“…Because these data are in contrast to our own observations2 that Treg cells are induced, expanded, or both with low-dose CsA treatment, we suppose that these…”
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Evaluation of calcineurin/NFAT inhibitor selectivity in primary human Th cells using bar‐coding and phospho‐flow cytometry by Frischbutter, Stefan, Schultheis, Katherine, Pätzel, Michael, Radbruch, Andreas, Baumgrass, Ria

“…Small molecular inhibitors are excellent tools for manipulating cell reactions. They are widely used in scientific research to study molecular mechanisms of…”
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A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema by Schulz, Florian, BS, Marenholz, Ingo, PhD, Fölster-Holst, Regina, MD, Chen, Christiane, MD, Sternjak, Alexander, BS, Baumgrass, Ria, PhD, Esparza-Gordillo, Jorge, PhD, Grüber, Christoph, MD, Nickel, Renate, MD, Schreiber, Stefan, MD, Stoll, Monika, PhD, Kurek, Michael, MD, Rüschendorf, Franz, PhD, Hubner, Norbert, MD, Wahn, Ulrich, MD, Lee, Young-Ae, MD

“…Background IL-31 is a novel cytokine that, when overexpressed in transgenic mice, induces severe itching dermatitis resembling human eczema. Objective We aimed…”
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The Novel Calcineurin Inhibitor CN585 Has Potent Immunosuppressive Properties in Stimulated Human T Cells by Erdmann, Frank, Weiwad, Matthias, Kilka, Susann, Karanik, Magdalena, Pätzel, Michael, Baumgrass, Ria, Liebscher, Jürgen, Fischer, Gunter

“…The Ca2+/calmodulin-dependent protein phosphatase calcineurin is a key mediator in antigen-specific T cell activation. Thus, inhibitors of calcineurin, such as…”
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SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data by Menssen, Adriane, Edinger, Götz, Grün, Joachim R, Haase, Ulrike, Baumgrass, Ria, Grützkau, Andreas, Radbruch, Andreas, Burmester, Gerd-R, Häupl, Thomas

“…Microarray expression profiling is becoming a routine technology for medical research and generates enormous amounts of data. However, reanalysis of public…”
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Dataset on the activation of Müller cells through macrophages upon hypoxia in the retina by Nürnberg, Christina, Kociok, Norbert, Brockmann, Claudia, Lischke, Timo, Crespo-Garcia, Sergio, Reichhart, Nadine, Wolf, Susanne, Baumgrass, Ria, Eming, Sabine A., Beer-Hammer, Sandra, Joussen, Antonia M.

“…The dataset presented in this article complements the article entitled “Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of…”
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Inhibition of calcineurin-NFAT signaling by the pyrazolopyrimidine compound NCI3 by Sieber, Matthias, Karanik, Magdalena, Brandt, Claudia, Blex, Christian, Podtschaske, Miriam, Erdmann, Frank, Rost, Rene, Serfling, Edgar, Liebscher, Jürgen, Pätzel, Michael, Radbruch, Andreas, Fischer, Gunter, Baumgrass, Ria

“…Dephosphorylation of NFAT by the Ca²⁺-calmodulin-dependent Ser/Thr protein phosphatase calcineurin is a bottleneck of T cell receptor-dependent activation of T…”
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Reversible Inhibition of Calcineurin by the Polyphenolic Aldehyde Gossypol by Baumgrass, Ria, Weiwad, Matthias, Erdmann, Frank, Liu, Jun O., Wunderlich, Dirk, Grabley, Susanne, Fischer, Gunter

“…The reversible inhibition of calcineurin (CaN), which is the only Ca2+/calmodulin-dependent protein Ser/Thr phosphatase, is thought to be a key functional…”
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Substitution in Position 3 of Cyclosporin A Abolishes the Cyclophilin-mediated Gain-of-function Mechanism but Not Immunosuppression by Baumgrass, Ria, Zhang, Yixin, Erdmann, Frank, Thiel, Andreas, Weiwad, Matthias, Radbruch, Andreas, Fischer, Gunter

“…Binary complex formation between the immunosuppressive drug cyclosporin A (CsA) and cyclophilin 18 is the prerequisite for the ability of CsA to inhibit the…”
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Unexpected Side Chain Effects at Residue 8 of Cyclosporin A Derivatives Allow Photoswitching of Immunosuppression by Zhang, Yixin, Erdmann, Frank, Baumgrass, Ria, Schutkowski, Mike, Fischer, Gunter

“…To dissect the enzyme inhibitory properties of the immunosuppressive cyclic undecapeptide cyclosporin A (CsA) and gain access to monospecific,…”
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Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology by Entschladen, Frank, Altschmied, Joachim, Baumgrass, Ria, Behrmann, Iris, Giehl, Klaudia, Hermanns, Heike, Huber, Otmar, Kieser, Arnd, Klotz, Lars-Oliver, Kubatzky, Katharina F, Hass, Ralf, Janssen, Ottmar, Friedrich, Karlheinz

“…The 13th meeting of the Signal Transduction Society was held in Weimar, from October 28 to 30, 2009. Special focus of the 2009 conference was "Aging and…”
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MODELING IL-2 GENE EXPRESSION IN HUMAN REGULATORY T CELLS by BENARY, MANUELA, BENDFELDT, HANNA, BAUMGRASS, RIA, HERZEL, HANSPETER

“…Interleukin-2 (IL-2) is one of the first cytokines to be expressed by T helper cells (Th cells) after antigen-specific stimulation. In contrast, regulatory T…”
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