Search Results - "Baumeister, Timm"

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors by Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Gunzner-Toste, Janet, Liederer, Bianca M, Ly, Justin, O’Brien, Thomas, Oh, Angela, Wang, Leslie, Wang, Weiru, Xiao, Yang, Zak, Mark, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

“…Crystal structures of several urea- and thiourea-derived compounds in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein were utilized to…”
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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors by Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Gunzner-Toste, Janet, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

“…Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual screening identified a thiourea analogue, compound 5, as a novel…”
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Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) by Dragovich, Peter S., Bair, Kenneth W., Baumeister, Timm, Ho, Yen-Ching, Liederer, Bianca M., Liu, Xiongcai, Liu, Yongbo, O’Brien, Thomas, Oeh, Jason, Sampath, Deepak, Skelton, Nicholas, Wang, Leslie, Wang, Weiru, Wu, Hongxing, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang

“…Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using…”
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Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors by Zheng, Xiaozhang, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Wang, Yunli, Yuen, Po-Wai, Bair, Kenneth W

“…A co-crystal structure of amide-containing compound (4) in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein and molecular modeling were…”
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Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors by Follows, Bruce, Fessler, Shawn, Baumeister, Timm, Campbell, Ann-Marie, Zablocki, Mary Margaret, Li, Hongbin, Gotur, Deepali, Wang, Zhongguo, Zheng, Xiaozhang, Molz, Lisa, Nguyen, Cokey, Herbertz, Torsten, Wang, Liann, Bair, Kenneth

“…[Display omitted] Mcl-1 is an anti-apoptotic protein overexpressed in hematological malignancies and several human solid tumors. Small molecule inhibition of…”
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Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) by Giannetti, Anthony M, Zheng, Xiaozhang, Skelton, Nicholas J, Wang, Weiru, Bravo, Brandon J, Bair, Kenneth W, Baumeister, Timm, Cheng, Eric, Crocker, Lisa, Feng, Yezhen, Gunzner-Toste, Janet, Ho, Yen-Ching, Hua, Rongbao, Liederer, Bianca M, Liu, Yongbo, Ma, Xiaolei, O’Brien, Thomas, Oeh, Jason, Sampath, Deepak, Shen, Youming, Wang, Chengcheng, Wang, Leslie, Wu, Hongxing, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhao, Guiling, Zhao, Qiang, Dragovich, Peter S

“…Potent, trans-2-(pyridin-3-yl)cyclopropane­carboxamide-containing inhibitors of the human nicotinamide phosphoribosyl­transferase (NAMPT) enzyme were…”
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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) by Zheng, Xiaozhang, Bair, Kenneth W., Bauer, Paul, Baumeister, Timm, Bowman, Krista K., Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Feng, Yezhen, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Li, Hong, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Ly, Justin, O’Brien, Thomas, Oeh, Jason, Oh, Angela, Reynolds, Dominic J., Sampath, Deepak, Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Tremayne, Jarrod, Wang, Leslie, Wang, Weiru, Wang, Zhongguo, Wu, Hongxing, Wu, Jiansheng, Xiao, Yang, Yang, Guangxing, Yuen, Po-wai, Zak, Mark, Dragovich, Peter S.

“…Potent, 1H-pyrazolo[3,4-b]pyridine-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using…”
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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility by Zak, Mark, Liederer, Bianca M., Sampath, Deepak, Yuen, Po-wai, Bair, Kenneth W., Baumeister, Timm, Buckmelter, Alexandre J., Clodfelter, Karl H., Cheng, Eric, Crocker, Lisa, Fu, Bang, Han, Bingsong, Li, Guangkun, Ho, Yen-Ching, Lin, Jian, Liu, Xiongcai, Ly, Justin, O’Brien, Thomas, Reynolds, Dominic J., Skelton, Nicholas, Smith, Chase C., Tay, Suzanne, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Dragovich, Peter S.

“…[Display omitted] Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility…”
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties by Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Mukadam, Sophie, O’Brien, Thomas, Oh, Angela, Reynolds, Dominic J., Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Sodhi, Jasleen, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang, Bair, Kenneth W., Dragovich, Peter S.

“…Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT)…”
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Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) by Dragovich, Peter S., Zhao, Guiling, Baumeister, Timm, Bravo, Brandon, Giannetti, Anthony M., Ho, Yen-Ching, Hua, Rongbao, Li, Guangkun, Liang, Xiaorong, Ma, Xiaolei, O’Brien, Thomas, Oh, Angela, Skelton, Nicholas J., Wang, Chengcheng, Wang, Weiru, Wang, Yunli, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhao, Qiang, Zheng, Xiaozhang

“…The fragment-based identification of two novel and potent biochemical inhibitors of the nicotinamide phosphoribosyltransferase (NAMPT) enzyme is described…”
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms by Korpal, Manav, Feala, Jacob, Puyang, Xiaoling, Zou, Jian, Ramos, Alex H, Wu, Jeremy, Baumeister, Timm, Yu, Lihua, Warmuth, Markus, Zhu, Ping

“…Although targeted therapies are initially effective, resistance inevitably emerges. Several methods, such as genetic analysis of resistant clinical specimens,…”
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms by Korpal, Manav, Feala, Jacob, Puyang, Xiaoling, Zou, Jian, Ramos, Alex H., Wu, Jeremy, Baumeister, Timm, Yu, Lihua, Warmuth, Markus, Zhu, Ping

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