Search Results - "Baumann, Philipp S"

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients by Dwir, Daniella, Giangreco, Basilio, Xin, Lijing, Tenenbaum, Liliane, Cabungcal, Jan-Harry, Steullet, Pascal, Goupil, Audrey, Cleusix, Martine, Jenni, Raoul, Chtarto, Abdelwahed, Baumann, Philipp S., Klauser, Paul, Conus, Philippe, Tirouvanziam, Rabindra, Cuenod, Michel, Do, Kim Q.

“…Various mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox…”
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N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis by Conus, Philippe, Seidman, Larry J, Fournier, Margot, Xin, Lijing, Cleusix, Martine, Baumann, Philipp S, Ferrari, Carina, Cousins, Ann, Alameda, Luis, Gholam-Rezaee, Mehdi, Golay, Philippe, Jenni, Raoul, Woo, T-U Wilson, Keshavan, Matcheri S, Eap, Chin B, Wojcik, Joanne, Cuenod, Michel, Buclin, Thierry, Gruetter, Rolf, Do, Kim Q

“…Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative stress may be a target in schizophrenia. A previous add-on trial with…”
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Partial‐volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia by Alemán‐Gómez, Yasser, Najdenovska, Elena, Roine, Timo, Fartaria, Mário João, Canales‐Rodríguez, Erick J., Rovó, Zita, Hagmann, Patric, Conus, Philippe, Do, Kim Q., Klauser, Paul, Steullet, Pascal, Baumann, Philipp S., Bach Cuadra, Meritxell

“…The structural complexity of the thalamus, due to its mixed composition of gray and white matter, make it challenging to disjoint and quantify each tissue…”
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N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial by Klauser, Paul, Xin, Lijing, Fournier, Margot, Griffa, Alessandra, Cleusix, Martine, Jenni, Raoul, Cuenod, Michel, Gruetter, Rolf, Hagmann, Patric, Conus, Philippe, Baumann, Philipp S., Do, Kim Q.

“…Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown…”
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Early onset of cannabis use and violent behavior in psychosis by Moulin, Valerie, Alameda, Luis, Framorando, David, Baumann, Philipp-S, Gholam, Mehdi, Gasser, Jacques, Do Cuenod, Kim-Q, Conus, Philippe

“…Although evidence from psychosis patients demonstrates the adverse effects of cannabis use (CU) at a young age and that the rate of CU is high in subgroups of…”
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Impaired metabolic reactivity to oxidative stress in early psychosis patients by Fournier, Margot, Ferrari, Carina, Baumann, Philipp S, Polari, Andrea, Monin, Aline, Bellier-Teichmann, Tanja, Wulff, Jacob, Pappan, Kirk L, Cuenod, Michel, Conus, Philippe, Do, Kim Q

“…Because increasing evidence point to the convergence of environmental and genetic risk factors to drive redox dysregulation in schizophrenia, we aim to clarify…”
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Stable biomarker identification for predicting schizophrenia in the human connectome by Gutiérrez-Gómez, Leonardo, Vohryzek, Jakub, Chiêm, Benjamin, Baumann, Philipp S., Conus, Philippe, Cuenod, Kim Do, Hagmann, Patric, Delvenne, Jean-Charles

“…•Stability of biomarker selection for predicting schizophrenia in the human connectome•Multi-modal connectome provides the best stability and classification…”
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Structural connectomics in brain diseases by Griffa, Alessandra, Baumann, Philipp S., Thiran, Jean-Philippe, Hagmann, Patric

“…Imaging the connectome in vivo has become feasible through the integration of several rapidly developing fields of science and engineering, namely magnetic…”
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Rate and predictors of disengagement in an early psychosis program with time limited intensification of treatment by Golay, Philippe, Ramain, Julie, Reiff, Caroline, Solida, Alessandra, Baumann, Philipp S., Conus, Philippe

“…Service disengagement is a frequent problem in early intervention in psychosis. The goal of this study was to evaluate the rate and variables associated with…”
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Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis by Xin, Lijing, Mekle, Ralf, Fournier, Margot, Baumann, Philipp S, Ferrari, Carina, Alameda, Luis, Jenni, Raoul, Lu, Huanxiang, Schaller, Benoit, Cuenod, Michel, Conus, Philippe, Gruetter, Rolf, Do, Kim Q

“…Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR)…”
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Moderating role of cannabis use between insight and depression in early psychosis by Elowe, Julien, Golay, Philippe, Baumann, Philipp S., Solida-Tozzi, Alessandra, Conus, Philippe

“…A high level of insight in first episode psychosis (FEP) is positively correlated to important prognostic factors such as medication adherence and functional…”
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Age at the time of exposure to trauma modulates the psychopathological profile in patients with early psychosis by Alameda, Luis, Golay, Philippe, Baumann, Philipp S, Ferrari, Carina, Do, Kim Q, Conus, Philippe

“…To examine the potential differential impact of childhood trauma, according to the age at the time of exposure, on the psychopathological profile of patients…”
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Mild Depressive Symptoms Mediate the Impact of Childhood Trauma on Long-Term Functional Outcome in Early Psychosis Patients by Alameda, Luis, Golay, Philippe, Baumann, Philipp S, Progin, Pierre, Mebdouhi, Nadir, Elowe, Julien, Ferrari, Carina, Do, Kim Q, Conus, Philippe

“…The mechanism linking childhood trauma (CT) to the functional deficits observed in early psychosis (EP) patients is as yet unknown. We aim to examine the…”
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Winter birth: A factor of poor functional outcome in a Swiss early psychosis cohort by Restellini, Romeo, Golay, Philippe, Jenni, Raoul, Baumann, Philipp S., Alameda, Luis, Allgäuer, Larissa, Steullet, Pascal, Abrahamyan Empson, Lilith, Mebdouhi, Nadir, Do, Kim Quang, Conus, Philippe, Dwir, Daniella, Klauser, Paul

“…Winter birth has consistently been identified as a risk factor for schizophrenia. This study aimed to determine whether individuals born during this season are…”
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Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis by Alameda, Luis, Fournier, Margot, Khadimallah, Ines, Griffa, Alessandra, Cleusix, Martine, Jenni, Raoul, Ferrari, Carina, Klauser, Paul, Baumann, Philipp S., Cuenod, Michel, Hagmann, Patric, Conus, Philippe, Do, Kim Q.

“…Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly through oxidative stress. As…”
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Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients by Alemán-Gómez, Yasser, Baumgartner, Thomas, Klauser, Paul, Cleusix, Martine, Jenni, Raoul, Hagmann, Patric, Conus, Philippe, Do, Kim Q, Bach Cuadra, Meritxell, Baumann, Philipp S, Steullet, Pascal

“…Although the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics…”
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Migration in patients with early psychosis: A 3-year prospective follow-up study by Golay, Philippe, Baumann, Philipp S., Jaton, Laure, Restellini, Romeo, Solida, Alessandra, Mebdouhi, Nadir, Conus, Philippe

“…•A substantive proportion of patients treated in early intervention programs have a background of migration.•Many elements suggest we should try to disentangle…”
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Characterization of early psychosis patients carrying a genetic vulnerability to redox dysregulation: a computational analysis of mechanism-based gene expression profile in fibroblasts by Giangreco, Basilio, Dwir, Daniella, Klauser, Paul, Jenni, Raoul, Golay, Philippe, Cleusix, Martine, Baumann, Philipp S., Cuénod, Michel, Conus, Philippe, Toni, Nicolas, Do, Kim Q.

“…In view of its heterogeneity, schizophrenia needs new diagnostic tools based on mechanistic biomarkers that would allow early detection. Complex interaction…”
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Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis by Seitz-Holland, Johanna, Alemán-Gómez, Yasser, Cho, Kang Ik K, Pasternak, Ofer, Cleusix, Martine, Jenni, Raoul, Baumann, Philipp S, Klauser, Paul, Conus, Philippe, Hagmann, Patric, Do, Kim Q, Kubicki, Marek, Dwir, Daniella

“…Increasing evidence points toward the role of the extracellular matrix, specifically matrix metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis…”
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N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study by Mullier, Emeline, Roine, Timo, Griffa, Alessandra, Xin, Lijing, Baumann, Philipp S, Klauser, Paul, Cleusix, Martine, Jenni, Raoul, Alemàn-Gómez, Yasser, Gruetter, Rolf, Conus, Philippe, Do, Kim Q, Hagmann, Patric

“…There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin…”
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