Search Results - "Baum, Erich W."

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes by Epplin, Rachel C., Paul, Shashwati, Herter, Loïc, Salome, Christophe, Hancock, Erin N., Larrow, Jay F., Baum, Erich W., Dunstan, David R., Ginsburg-Moraff, Carol, Fessard, Thomas C., Brown, M. Kevin

“…Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of…”
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Intermolecular C−H Bond Activation Promoted by a Titanium Alkylidyne by Bailey, Brad C, Fan, Hongjun, Baum, Erich W, Huffman, John C, Baik, Mu-Hyun, Mindiola, Daniel J

“…The transient titanium alkylidyne complex (PNP)Ti⋮C t Bu (PNP = N-[2-P(CHMe2)2-4-methylphenyl]2 -), prepared from α-hydrogen abstraction of the corresponding…”
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Diastereoselective Intramolecular Temporary Silicon-Tethered Rhodium-Catalyzed [4+2+2] Cycloisomerization Reactions:  Regiospecific Incorporation of Substituted 1,3-Butadienes by Evans, P. Andrew, Baum, Erich W

“…Transition metal-catalyzed carbocyclization reactions represent powerful methods for the construction of complex polycyclic systems. We have developed a…”
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Intermolecular Transition Metal-Catalyzed [4 + 2 + 2] Cycloaddition Reactions:  A New Approach to the Construction of Eight-Membered Rings by Evans, P. Andrew, Robinson, John E, Baum, Erich W, Fazal, Aleem N

“…Transition metal-catalyzed cycloaddition reactions represent powerful methods for the construction of complex polycyclic systems. We have developed a new…”
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Diastereoselective Intermolecular Rhodium-Catalyzed [4 + 2 + 2] Carbocyclization Reactions:  Computational and Experimental Evidence for the Intermediacy of an Alternative Metallacycle Intermediate by Baik, Mu-Hyun, Baum, Erich W, Burland, Matthew C, Evans, P. Andrew

“…Intermolecular rhodium-catalyzed [m + n + o] reactions of 1,6-enynes and various π-components (carbon monoxide, alkynes, 1,3-butadienes, etc.) provide an…”
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Waterless Condensers for the Teaching Laboratory: An Adaptation of Traditional Glassware by Baum, Erich W, Esteb, John J, Wilson, Anne M

“…A simple adaptation of traditional “chemistry kit” condensers for the organic chemistry teaching laboratory is described. These waterless condensers have been…”
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Static Fluid Condensers for the Containment of Refluxing Solvent by Baum, Erich W, O’Callaghan, Iain, Cinninger, Leander, Esteb, John J, Wilson, Anne M

“…Allihn-type condensers have been modified to contain a fixed volume of ethylene glycol. These condensers do not require circulating fluid or bulky and…”
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Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) by Emmitte, Kyle A., Wilson, Brian J., Baum, Erich W., Emerson, Holly K., Kuntz, Kevin W., Nailor, Kristen E., Salovich, James M., Smith, Stephon C., Cheung, Mui, Gerding, Roseanne M., Stevens, Kirk L., Uehling, David E., Mook, Robert A., Moorthy, Ganesh S., Dickerson, Scott H., Hassell, Anne M., Anthony Leesnitzer, M., Shewchuk, Lisa M., Groy, Arthur, Rowand, Jason L., Anderson, Kelly, Atkins, Charity L., Yang, Jingsong, Sabbatini, Peter, Kumar, Rakesh

“…The optimization of imidazo[1,2- a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice…”
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Intermolecular Transition Metal-Catalyzed [4 + 2 + 2] Cycloaddition Reactions:  A New Approach to the Construction of Eight-Membered Rings   [J. Am. Chem. Soc. 2002, 124 (30), 8782−8783]. by Evans, P. Andrew, Robinson, John E, Baum, Erich W, Fazal, Aleem N

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New metal-catalyzed carbocyclization reactions for the construction of complex natural products by Evans, P. Andrew, Baum, Erich W., Fazal, Aleem N., Lai, Kwong Wah, Robinson, John E., Sawyer, James R.

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