Search Results - "Baulieu, Etienne Emile"

Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin by Bielecki, Bartosz, Mattern, Claudia, Ghoumari, Abdel M., Javaid, Sumaira, Smietanka, Kaja, Ghanem, Charly Abi, Mhaouty-Kodja, Sakina, Ghandour, M. Said, Baulieu, Etienne-Emile, Franklin, Robin J. M., Schumacher, Michael, Traiffort, Elisabeth

“…Lost myelin can be replaced after injury or during demyelinating diseases in a regenerative process called remyelination. In the central nervous system (CNS),…”
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3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders by Bianchi, Massimiliano, Baulieu, Etienne-Emile

“…Emerging evidence suggests that the pathogenesis of depressive disorders (DDs) is associated with neuronal abnormalities in brain microtubule function,…”
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Steroids and Brain, a Rising Bio-Medical Domain: a Perspective by Baulieu, Etienne-Emile

“…Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the…”
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role for FKBP52 in Tau protein function by Chambraud, Béatrice, Sardin, Elodie, Giustiniani, Julien, Dounane, Omar, Schumacher, Michael, Goedert, Michel, Baulieu, Etienne-Emile

“…Tau is a microtubule-associated protein, which is widely expressed in the central nervous system, predominantly in neurons, where it regulates microtubule…”
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Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum by Meffre, Delphine, Shackleford, Ghjuvan’Ghjacumu, Hichor, Mehdi, Gorgievski, Victor, Tzavara, Eleni T., Trousson, Amalia, Ghoumari, Abdel M., Deboux, Cyrille, Oumesmar, Brahim Nait, Liere, Philippe, Schumacher, Michael, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Grenier, Julien, Massaad, Charbel

“…The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors…”
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Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy by Giustiniani, Julien, Chambraud, Béatrice, Sardin, Elodie, Dounane, Omar, Guillemeau, Kevin, Nakatani, Hiroko, Paquet, Dominik, Kamah, Amina, Landrieu, Isabelle, Lippens, Guy, Baulieu, Etienne-Emile, Tawk, Marcel

“…The Tau protein is the major component of intracellular filaments observed in a number of neurodegenerative diseases known as tauopathies. The pathological…”
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The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease by Farina, Francesca, Lambert, Emmanuel, Commeau, Lucie, Lejeune, François-Xavier, Roudier, Nathalie, Fonte, Cosima, Parker, J. Alex, Boddaert, Jacques, Verny, Marc, Baulieu, Etienne-Emile, Neri, Christian

“…Helping neurons to compensate for proteotoxic stress and maintain function over time (neuronal compensation) has therapeutic potential in aging and…”
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Lithium enhances remyelination of peripheral nerves by Makoukji, Joelle, Belle, Martin, Meffre, Delphine, Stassart, Ruth, Grenier, Julien, Shackleford, Ghjuvan'Ghjacumu, Fledrich, Robert, Fonte, Cosima, Branchu, Julien, Goulard, Marie, de Waele, Catherine, Charbonnier, Frédéric, Sereda, Michael W, Baulieu, Etienne-Emile, Schumacher, Michael, Bernard, Sophie, Massaad, Charbel

“…Glycogen synthase kinase 3β (GSK3β) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents…”
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Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System by Schumacher, Michael, Guennoun, Rachida, Ghoumari, Abdel, Massaad, Charbel, Robert, Françoise, El-Etr, Martine, Akwa, Yvette, Rajkowski, Krzysztof, Baulieu, Etienne-Emile

“…The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials. Their outcome has been…”
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Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis by Shackleford, Ghjuvan’Ghjacumu, Sampathkumar, Nirmal Kumar, Hichor, Mehdi, Weill, Laure, Meffre, Delphine, Juricek, Ludmila, Laurendeau, Ingrid, Chevallier, Aline, Ortonne, Nicolas, Larousserie, Frédérique, Herbin, Marc, Bièche, Ivan, Coumoul, Xavier, Beraneck, Mathieu, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Pasmant, Eric, Massaad, Charbel

“…Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in xenobiotic metabolism. Plexiform neurofibromas (PNFs) can transform into…”
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Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study by Vukusic, Sandra, Ionescu, Iuliana, Cornu, Catherine, Bossard, Nadine, Durand-Dubief, Françoise, Cotton, François, Durelli, Luca, Marignier, Romain, Gignoux, Laurence, Laplaud, David-Axel, Moreau, Thibault, Clavelou, Pierre, De Seze, Jérôme, Debouverie, Marc, Brassat, David, Pelletier, Jean, Lebrun-Frenay, Christine, Le Page, Emmanuelle, Castelnovo, Giovanni, Berger, Eric, Hautecoeur, Patrick, Heinzlef, Olivier, Trojano, Maria, Patti, Francesco, Baulieu, Etienne-Emile, Remontet, Laurent, El-Etr, Martine

“…Background: Sex steroids could explain the course of multiple sclerosis (MS) in pregnancy. Objective: To compare the annualized relapse rate (ARR) 12 weeks…”
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Electronic circular dichroism and nuclear magnetic resonance studies of peptides derived from the FKBP52‐interacting β‐turn of the hERα ligand‐binding domain by Byrne, Cillian, Belnou, Mathilde, Baulieu, Etienne‐Emile, Lequin, Olivier, Jacquot, Yves

“…When located at the surface of proteins, turns containing a Pro‐Gly (PG) motif are often involved in protein/protein interactions and may participate in…”
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Etifoxine improves peripheral nerve regeneration and functional recovery by Girard, Christelle, Liu, Song, Cadepond, Françoise, Adams, David, Lacroix, Catherine, Verleye, Marc, Gillardin, Jean-Marie, Baulieu, Etienne-Emile, Schumacher, Michael, Schweizer-Groyer, Ghislaine

“…Peripheral nerves show spontaneous regenerative responses, but recovery after injury or peripheral neuropathies (toxic, diabetic, or chronic inflammatory…”
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A steroid hormone that extends the lifespan of Caenorhabditis elegans by Broué, Florence, Liere, Philippe, Kenyon, Cynthia, Baulieu, Etienne‐Emile

“…Summary Removing the germline of Caenorhabditis elegans extends lifespan. This lifespan extension requires the nuclear receptor DAF‐12 and the cytochrome P450…”
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Neurosteroid Quantification in Human Brain Regions: Comparison between Alzheimer’s and Nondemented Patients by Weill-Engerer, Sébastien, David, Jean-Philippe, Sazdovitch, Véronique, Liere, Philippe, Eychenne, Bernard, Pianos, Antoine, Schumacher, Michael, Delacourte, André, Baulieu, Etienne-Emile, Akwa, Yvette

“…Some neurosteroids have been shown to display beneficial effects on neuroprotection in rodents. To investigate the physiopathological significance of…”
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Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons by Sanchez, Pascal E, Fares, Raafat P, Risso, Jean-Jacques, Bonnet, Chantal, Bouvard, Sandrine, Le-Cavorsin, Marion, Georges, Béatrice, Moulin, Colette, Belmeguenai, Amor, Bodennec, Jacques, Morales, Anne, Pequignot, Jean-Marc, Baulieu, Etienne-Emile, Levine, Robert A, Bezin, Laurent

“…Erythropoietin receptor (EpoR) binding mediates neuroprotection by endogenous Epo or by exogenous recombinant human (rh)Epo. The level of EpoR gene expression…”
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Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): A pilot study by Dumas de La Roque, Eric, Savineau, Jean-Pierre, Metivier, Anne-Cécile, Billes, Marc-Alain, Kraemer, Jean-Philippe, Doutreleau, Stéphane, Jougon, Jacques, Marthan, Roger, Moore, Nicholas, Fayon, Michael, Baulieu, Étienne-Émile, Dromer, Claire

“…Abstract Objectives It was previously shown that dehydroepiandrosterone (DHEA) reverses chronic hypoxia-induced pulmonary hypertension (PH) in rats, but…”
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Microtubule-Associated Protein 2 (MAP2) Is a Neurosteroid Receptor by Fontaine-Lenoir, Virginie, Chambraud, Béatrice, Fellous, Arlette, David, Sébastien, Duchossoy, Yann, Baulieu, Etienne-Emile, Robel, Paul

“…The neurosteroid pregnenolone (PREG) and its chemically synthesized analog 3β-methoxypregnenolone (MePREG) bind to microtubule-associated protein 2 (MAP2) and…”
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7α-Hydroxypregnenolone Acts as a Neuronal Activator to Stimulate Locomotor Activity of Breeding Newts by Means of the Dopaminergic System by Matsunaga, Masahiro, Ukena, Kazuyoshi, Baulieu, Etienne-Emile, Tsutsui, Kazuyoshi, Roberts, Eugene

“…It is becoming clear that steroids can be synthesized de novo by the brain and other nervous systems. Such steroids are called neurosteroids, and de novo…”
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Identification of the Tau phosphorylation pattern that drives its aggregation by Despres, Clément, Byrne, Cillian, Qi, Haoling, Cantrelle, François-Xavier, Huvent, Isabelle, Chambraud, Béatrice, Baulieu, Etienne-Emile, Jacquot, Yves, Landrieu, Isabelle, Lippens, Guy, Smet-Nocca, Caroline

“…Determining the functional relationship between Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosphorylation…”
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