Search Results - "Baulch, Janet"

Radiation-induced genomic instability, epigenetic mechanisms and the mitochondria: a dysfunctional ménage a trois? by Baulch, Janet E.

“…Purpose: This article presents a perspective examining the evidence for a link between radiation-induced genomic instability, epigenetic mechanisms and…”
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Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation by Markarian, Mineh, Krattli, Jr, Robert P, Baddour, Jabra D, Alikhani, Leila, Giedzinski, Erich, Usmani, Manal T, Agrawal, Anshu, Baulch, Janet E, Tenner, Andrea J, Acharya, Munjal M

“…The adverse neurocognitive sequelae following clinical radiotherapy (RT) for central nervous system (CNS) malignancies are often long-lasting without any…”
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Extracellular Vesicle-Derived miR-124 Resolves Radiation-Induced Brain Injury by Leavitt, Ron J, Acharya, Munjal M, Baulch, Janet E, Limoli, Charles L

“…Radiation-induced cognitive dysfunction (RICD) is a progressive and debilitating health issue facing patients following cranial radiotherapy to control central…”
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Elimination of microglia improves cognitive function following cranial irradiation by Acharya, Munjal M., Green, Kim N., Allen, Barrett D., Najafi, Allison R., Syage, Amber, Minasyan, Harutyun, Le, Mi T., Kawashita, Takumi, Giedzinski, Erich, Parihar, Vipan K., West, Brian L., Baulch, Janet E., Limoli, Charles L.

“…Cranial irradiation for the treatment of brain cancer elicits progressive and severe cognitive dysfunction that is associated with significant neuropathology…”
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Cosmic radiation exposure and persistent cognitive dysfunction by Parihar, Vipan K., Allen, Barrett D., Caressi, Chongshan, Kwok, Stephanie, Chu, Esther, Tran, Katherine K., Chmielewski, Nicole N., Giedzinski, Erich, Acharya, Munjal M., Britten, Richard A., Baulch, Janet E., Limoli, Charles L.

“…The Mars mission will result in an inevitable exposure to cosmic radiation that has been shown to cause cognitive impairments in rodent models, and possibly in…”
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miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury by Leavitt, Ron J., Limoli, Charles L., Baulch, Janet E.

“…Purpose: This review compiles what is known about extracellular vesicles (EVs), their bioactive cargo, and how they might be used to treat radiation-induced…”
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Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease by Apodaca, Lauren A, Baddour, Al Anoud D, Garcia, Jr, Camilo, Alikhani, Leila, Giedzinski, Erich, Ru, Ning, Agrawal, Anshu, Acharya, Munjal M, Baulch, Janet E

“…Regenerative therapies to mitigate Alzheimer's disease (AD) neuropathology have shown very limited success. In the recent era, extracellular vesicles (EVs)…”
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BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis by Usmani, Manal T., Krattli, Robert P., El-Khatib, Sanad M., Le, Anh C. D., Smith, Sarah M., Baulch, Janet E., Ng, Ding Quan, Acharya, Munjal M., Chan, Alexandre

“…Cancer-related cognitive impairment (CRCI) considerably affects the quality of life of millions of cancer survivors. Brain-derived neurotrophic factor (BDNF)…”
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Radiation-induced epigenetic alterations after low and high LET irradiations by Aypar, Umut, Morgan, William F, Baulch, Janet E

“…Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability…”
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Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain by Baulch, Janet E., Acharya, Munjal M., Allen, Barrett D., Ru, Ning, Chmielewski, Nicole N., Martirosian, Vahan, Giedzinski, Erich, Syage, Amber, Park, Audrey L., Benke, Sarah N., Parihar, Vipan K., Limoli, Charles L.

“…Cancer survivors face a variety of challenges as they cope with disease recurrence and a myriad of normal tissue complications brought on by radio- and…”
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Epigenetic changes and nontargeted radiation effects--Is there a link by Kovalchuk, Olga, Baulch, Janet E

“…It is now well accepted that the effects of ionizing radiation (IR) exposure can be noticed far beyond the borders of the directly irradiated tissue. IR can…”
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Detrimental impacts of mixed-ion radiation on nervous system function by Klein, Peter M., Parihar, Vipan K., Szabo, Gergely G., Zöldi, Miklós, Angulo, Maria C., Allen, Barrett D., Amin, Amal N., Nguyen, Quynh-Anh, Katona, István, Baulch, Janet E., Limoli, Charles L., Soltesz, Ivan

“…Galactic cosmic radiation (GCR), composed of highly energetic and fully ionized atomic nuclei, produces diverse deleterious effects on the body. In researching…”
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Mitigation of helium irradiation-induced brain injury by microglia depletion by Allen, Barrett D, Syage, Amber R, Maroso, Mattia, Baddour, Al Anoud D, Luong, Valerie, Minasyan, Harutyun, Giedzinski, Erich, West, Brian L, Soltesz, Ivan, Limoli, Charles L, Baulch, Janet E, Acharya, Munjal M

“…Cosmic radiation exposures have been found to elicit cognitive impairments involving a wide-range of underlying neuropathology including elevated oxidative…”
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The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation by Limoli, Charles L., Kramár, Eniko A., Almeida, Aymeric, Petit, Benoit, Grilj, Veljko, Baulch, Janet E., Ballesteros-Zebadua, Paola, Loo, Billy W, Wood, Marcelo A., Vozenin, Marie-Catherine

“…•FLASH sparing in the brain can be achieved under standard fractionation.•Long-term potentiation (LTP) is sensitive to dose-rate modulation.•LTP measures…”
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Extracellular vesicles from GABAergic but not glutamatergic neurons protect against neurological dysfunction following cranial irradiation by Smith, Sarah M., Ranjan, Kashvi, Hoover, Brianna M., Drayson, Olivia G. G., Acharya, Munjal M., Kramár, Eniko A., Baulch, Janet E., Limoli, Charles L.

“…Cranial irradiation used to control brain malignancies invariably leads to progressive and debilitating declines in cognition. Clinical efforts implementing…”
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Immune and Inflammatory Determinants Underlying Alzheimer’s Disease Pathology by Baulch, Janet E., Acharya, Munjal M., Agrawal, Sudhanshu, Apodaca, Lauren A., Monteiro, Clarice, Agrawal, Anshu

“…This study examines the link between peripheral immune changes in perpetuation of the Alzheimer’s disease (AD) neuropathology and cognitive deficits. Our…”
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Dissecting Differential Complex Behavioral Responses to Simulated Space Radiation Exposures by Britten, Richard A, Fesshaye, Arriyam, Ihle, Peter, Wheeler, Andrew, Baulch, Janet E, Limoli, Charles L, Stark, Craig E

“…This study has established the impact that space radiation exposure has on the capability of rats to successfully negotiate behavioral tasks of increasing…”
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Chronic Low Dose Neutron Exposure Results in Altered Neurotransmission Properties of the Hippocampus-Prefrontal Cortex Axis in Both Mice and Rats by Krishnan, Balaji, Natarajan, Chandramouli, Bourne, Krystyn Z, Alikhani, Leila, Wang, Juan, Sowa, Allison, Groen, Katherine, Perry, Bayley, Dickstein, Dara L, Baulch, Janet E, Limoli, Charles L, Britten, Richard A

“…The proposed deep space exploration to the moon and later to Mars will result in astronauts receiving significant chronic exposures to space radiation (SR). SR…”
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Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice by Hinzman, Charles P., Baulch, Janet E., Mehta, Khyati Y., Girgis, Michael, Bansal, Shivani, Gill, Kirandeep, Li, Yaoxiang, Limoli, Charles L., Cheema, Amrita K.

“…Ionizing radiation exposure to the brain is common for patients with a variety of CNS related malignancies. This exposure is known to induce structural and…”
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Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy by Allen, Barrett D, Alaghband, Yasaman, Kramár, Eniko A, Ru, Ning, Petit, Benoit, Grilj, Veljko, Petronek, Michael S, Pulliam, Casey F, Kim, Rachel Y, Doan, Ngoc-Lien, Baulch, Janet E, Wood, Marcelo A, Bailat, Claude, Spitz, Douglas R, Vozenin, Marie-Catherine, Limoli, Charles L

“…Abstract Background Ultrahigh dose-rate radiotherapy (FLASH-RT) affords improvements in the therapeutic index by minimizing normal tissue toxicities without…”
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