Search Results - "Bauer, Shawn M."

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan

“…Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of…”
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Total Synthesis of Motuporin (Nodularin-V) by Bauer, Shawn M, Armstrong, Robert W

“…The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products…”
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ADP receptor antagonists as antiplatelet therapeutics by Bauer, Shawn M

“…With the cloning of the P2Y12 receptor, the molecular basis for ADP-induced platelet aggregation is seemingly complete. Two platelet-bound ADP receptors, P2Y1…”
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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors by JIA, Zhaozhong J, TING SU, WENRONG HUANG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, HUTCHALEELAHA, Athiwat, HOLLENBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, YANHONG WU, GOLDMAN, Erick A, WENHAO LI, PENGLIE ZHANG, CLIZBE, Lane A, YONGHONG SONG, BAUER, Shawn M

“…A class of N,N-dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines has been…”
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Parallel synthesis and structure–activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors by Bauer, Shawn M, Goldman, Erick A, Huang, Wenrong, Su, Ting, Wang, Lingyan, Woolfrey, John, Wu, Yanhong, Zuckett, Jingmei F, Arfsten, Ann, Huang, Brian, Kothule, Jaya, Lin, Joyce, May, Bridget, Sinha, Uma, Wong, Paul W, Hutchaleelaha, Athiwat, Scarborough, Robert M, Zhu, Bing-Yan

“…Parallel synthesis and iterative optimization led to the discovery of a series of inhibitors having excellent in vitro and promising in vivo properties…”
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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J, Bauer, Shawn M, Goldman, Erick A, Probst, Gary D, Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W, Edwards, Susan T, Arfsten, Ann E, Clizbe, Lane A, Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan

“…Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of…”
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Construction of combinatorial chemical libraries using a rapid and efficient solid phase synthesis based on a multicomponent condensation reaction by Kim, Sang Woong, Bauer, Shawn M., Armstrong, Robert W.

“…A 96 member library of acylated dipeptides based on a known anticonvulsant was synthesized utilizing an Ugi four component condensation followed by…”
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Multicomponent solution phase synthesis of dehydroamino acid derivatives based on the Passerini reaction by Kim, Sang Woong, Bauer, Shawn M., Armstrong, Robert W.

“…We have synthesized a library of dehydroamino acid derivatives using a Passerini three component condensation reaction. A number of structurally diverse inputs…”
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