Search Results - "Bauer, M M T"

Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease by Peng, Ruoqi, Sridhar, Sriram, Tyagi, Gaurav, Phillips, Jonathan E, Garrido, Rosario, Harris, Paul, Burns, Lisa, Renteria, Lorena, Woods, John, Chen, Leena, Allard, John, Ravindran, Palanikumar, Bitter, Hans, Liang, Zhenmin, Hogaboam, Cory M, Kitson, Chris, Budd, David C, Fine, Jay S, Bauer, Carla M T, Stevenson, Christopher S

“…The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly…”
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Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection by Bauer, Carla M T, Zavitz, Caleb C J, Botelho, Fernando M, Lambert, Kristen N, Brown, Earl G, Mossman, Karen L, Taylor, John D, Stämpfli, Martin R

“…Chronic obstructive pulmonary disease is a progressive lung disease that is punctuated by periods of exacerbations (worsening of symptoms) that are…”
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An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses by DeWitte-Orr, Stephanie J, Collins, Susan E, Bauer, Carla M T, Bowdish, Dawn M, Mossman, Karen L

“…Extracellular RNA is becoming increasingly recognized as a signaling molecule. Virally derived double stranded (ds)RNA released into the extracellular space…”
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IL-17A and the Promotion of Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Roos, Abraham B, Sethi, Sanjay, Nikota, Jake, Wrona, Catherine T, Dorrington, Michael G, Sandén, Caroline, Bauer, Carla M T, Shen, Pamela, Bowdish, Dawn, Stevenson, Christopher S, Erjefält, Jonas S, Stampfli, Martin R

“…Nontypeable Haemophilus influenzae (NTHi) causes acute exacerbation of chronic obstructive pulmonary disease (AECOPD). IL-17A is central for neutrophilic…”
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Adjuvant and Anti-Inflammatory Properties of Cigarette Smoke in Murine Allergic Airway Inflammation by Trimble, Nancy J, Botelho, Fernando M, Bauer, Carla M. T, Fattouh, Ramzi, Stampfli, Martin R

“…The impact of cigarette smoke on allergic asthma remains controversial both clinically and experimentally. The objective of this study was to investigate, in a…”
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First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer by Niu, J., Maurice-Dror, C., Lee, D.H., Kim, D.-W., Nagrial, A., Voskoboynik, M., Chung, H.C., Mileham, K., Vaishampayan, U., Rasco, D., Golan, T., Bauer, T.M., Jimeno, A., Chung, V., Chartash, E., Lala, M., Chen, Q., Healy, J.A., Ahn, M.-J.

“…In this first-in-human phase 1 study (NCT02964013; MK-7684-001), we investigated the safety and efficacy of the anti-TIGIT (T cell immunoglobulin and ITIM…”
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IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice by Botelho, Fernando M, Bauer, Carla M T, Finch, Donna, Nikota, Jake K, Zavitz, Caleb C J, Kelly, Ashling, Lambert, Kristen N, Piper, Sian, Foster, Martyn L, Goldring, James J P, Wedzicha, Jadwiga A, Bassett, Jennifer, Bramson, Jonathan, Iwakura, Yoichiro, Sleeman, Matthew, Kolbeck, Roland, Coyle, Anthony J, Humbles, Alison A, Stämpfli, Martin R

“…Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality…”
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Intracranial and extracranial efficacy of lorlatinib in patients with ALK-positive non-small-cell lung cancer previously treated with second-generation ALK TKIs by Felip, E., Shaw, A.T., Bearz, A., Camidge, D.R., Solomon, B.J., Bauman, J.R., Bauer, T.M., Peters, S., Toffalorio, F., Abbattista, A., Thurm, H., Peltz, G., Wiltshire, R., Besse, B.

“…Lorlatinib, a potent, brain-penetrant, third-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), has substantial activity against…”
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First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors by Bang, Y.J., Giaccone, G., Im, S.A., Oh, D.Y., Bauer, T.M., Nordstrom, J.L., Li, H., Chichili, G.R., Moore, P.A., Hong, S., Stewart, S.J., Baughman, J.E., Lechleider, R.J., Burris, H.A.

“…Margetuximab is an anti-HER2 antibody that binds with elevated affinity to both the lower and higher affinity forms of CD16A, an Fc-receptor important for…”
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House dust mite models: Will they translate clinically as a superior model of asthma? by Phillips, Jonathan E., PhD, Peng, Ruoqi, MD, Harris, Paul, BS, Burns, Lisa, BS, Renteria, Lorena, Lundblad, Lennart K.A., PhD, Fine, Jay S., PhD, Bauer, Carla M.T., PhD, Stevenson, Christopher S., PhD

“…The data presented here significantly extend the current knowledge by demonstrating that HDM sensitization and challenge in mice induces a type I…”
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Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study by Hong, D.S., Bauer, T.M., Lee, J.J., Dowlati, A., Brose, M.S., Farago, A.F., Taylor, M., Shaw, A.T., Montez, S., Meric-Bernstam, F., Smith, S., Tuch, B.B., Ebata, K., Cruickshank, S., Cox, M.C., Burris, H.A., Doebele, R.C.

“…NTRK1, NTRK2 and NTRK3 gene fusions (NTRK gene fusions) occur in a range of adult cancers. Larotrectinib is a potent and highly selective ATP-competitive…”
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Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer: clinical and biomarker results from a phase I trial by Schuler, M., Berardi, R., Lim, W.-T., de Jonge, M., Bauer, T.M., Azaro, A., Gottfried, M., Han, J.-Y., Lee, D.H., Wollner, M., Hong, D.S., Vogel, A., Delmonte, A., Akimov, M., Ghebremariam, S., Cui, X., Nwana, N., Giovannini, M., Kim, T.M.

“…Dysregulation of receptor tyrosine kinase MET by various mechanisms occurs in 3%–4% of non-small-cell lung cancer (NSCLC) and is associated with unfavorable…”
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Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice by Botelho, Fernando M, Nikota, Jake K, Bauer, Carla M T, Morissette, Mathieu C, Iwakura, Yoichiro, Kolbeck, Roland, Finch, Donna, Humbles, Alison A, Stämpfli, Martin R

“…Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1…”
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Prolonged sedation due to accumulation of conjugated metabolites of midazolam by Bauer, T M, Ritz, R, Haberthür, C, Ha, H R, Hunkeler, W, Sleight, A J, Scollo-Lavizzari, G, Haefeli, W E

“…Midazolam is a short-acting benzodiazepine routinely used in intensive-care medicine. Conjugates of its main metabolite, alpha-hydroxymidazolam, have been…”
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Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma by Botelho, Fernando M, Llop-Guevara, Alba, Trimble, Nancy J, Nikota, Jake K, Bauer, Carla M T, Lambert, Kristen N, Kianpour, Sussan, Jordana, Manel, Stämpfli, Martin R

“…Although a similar prevalence of smoking is evident among patients with asthma and the general population, little is known about the impact of cigarette smoke…”
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Magnetic field fluctuations across the Earth's bow shock by CZAYKOWSKA, A, BAUER, T. M, TREUMANN, R. A, BAUMJOHANN, W

“…We present a statistical analysis of 132 dayside (LT 0700-1700) bow shock crossings of the AMPTE/IRM spacecraft. We perform a superposed epoch analysis of low…”
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Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth by Ensan, Sherine, Li, Angela, Besla, Rickvinder, Degousee, Norbert, Cosme, Jake, Roufaiel, Mark, Shikatani, Eric A, El-Maklizi, Mahmoud, Williams, Jesse W, Robins, Lauren, Li, Cedric, Lewis, Bonnie, Yun, Tae Jin, Lee, Jun Seong, Wieghofer, Peter, Khattar, Ramzi, Farrokhi, Kaveh, Byrne, John, Ouzounian, Maral, Zavitz, Caleb C J, Levy, Gary A, Bauer, Carla M T, Libby, Peter, Husain, Mansoor, Swirski, Filip K, Cheong, Cheolho, Prinz, Marco, Hilgendorf, Ingo, Randolph, Gwendalyn J, Epelman, Slava, Gramolini, Anthony O, Cybulsky, Myron I, Rubin, Barry B, Robbins, Clinton S

“…Macrophages densely populate the arterial wall, yet their origin and homeostasis are poorly understood. Robbins and colleagues show that arterial macrophages…”
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Hepatitis C virus infection in intravenous drug users by Harder, J., Walter, E., Riecken, B., Ihling, C., Bauer, T.M.

“…Intravenous drug use (IVDU) remains a major means of hepatitis C virus (HCV) transmission. In this study, 101 drug users were studied prospectively after…”
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Cigarette Smoke Exposure Attenuates Cytokine Production by Mouse Alveolar Macrophages by Gaschler, Gordon J, Zavitz, Caleb C. J, Bauer, Carla M. T, Skrtic, Marko, Lindahl, Maria, Robbins, Clinton S, Chen, Biao, Stampfli, Martin R

“…Alveolar macrophages (aMs) play a central role in respiratory host defense by sensing microbial antigens and initiating immune-inflammatory responses early in…”
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Lung Epithelial CCAAT/Enhancer binding Protein-β Is Necessary for the Integrity of Inflammatory Responses to Cigarette Smoke by DIDON, Lukas, BARTON, Jenny L, ROOS, Abraham B, GASCHLER, Gordon J, BAUER, Carla M. T, BERG, Tove, STÄMPFLI, Martin R, NORD, Magnus

“…Cigarette smoke is the major cause of chronic obstructive pulmonary disease and lung cancer. The mechanisms by which smoking induces pulmonary dysfunction are…”
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