Search Results - "Bauer, Armin"

Industrial natural product chemistry for drug discovery and development by Bauer, Armin, Brönstrup, Mark

“…Covering: up to March 2013. In addition to their prominent role in basic biological and chemical research, natural products are a rich source of commercial…”
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Photoredox-Catalyzed Site-Selective Generation of Carbanions from C(sp3)–H Bonds in Amines by Murugesan, Kathiravan, Donabauer, Karsten, Narobe, Rok, Derdau, Volker, Bauer, Armin, König, Burkhard

“…The selective activation of sp3 carbon–hydrogen bonds in the presence of multiple C–H bonds is challenging and remains of supreme importance in chemical…”
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Targeting DnaN for tuberculosis therapy using novel griselimycins by Kling, Angela, Lukat, Peer, Almeida, Deepak V., Bauer, Armin, Fontaine, Evelyne, Sordello, Sylvie, Zaburannyi, Nestor, Herrmann, Jennifer, Wenzel, Silke C., König, Claudia, Ammerman, Nicole C., Barrio, María Belén, Borchers, Kai, Bordon-Pallier, Florence, Brönstrup, Mark, Courtemanche, Gilles, Gerlitz, Martin, Geslin, Michel, Hammann, Peter, Heinz, Dirk W., Hoffmann, Holger, Klieber, Sylvie, Kohlmann, Markus, Kurz, Michael, Lair, Christine, Matter, Hans, Nuermberger, Eric, Tyagi, Sandeep, Fraisse, Laurent, Grosset, Jacques H., Lagrange, Sophie, Müller, Rolf

“…The discovery of Streptomyces-produced streptomycin founded the age of tuberculosis therapy. Despite the subsequent development of a curative regimen for this…”
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Effects of a Brief Electronic Mindfulness-Based Intervention on Relieving Prenatal Depression and Anxiety in Hospitalized High-Risk Pregnant Women: Exploratory Pilot Study by Goetz, Maren, Schiele, Claudia, Müller, Mitho, Matthies, Lina M, Deutsch, Thomas M, Spano, Claudio, Graf, Johanna, Zipfel, Stephan, Bauer, Armin, Brucker, Sara Y, Wallwiener, Markus, Wallwiener, Stephanie

“…Peripartum depression and anxiety disorders are highly prevalent and are correlated with adverse maternal and neonatal outcomes. Antenatal care in Germany does…”
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Observational database study on preeclampsia and postpartum medical care up to 7.5 years after birth by Scholz, Anna S., Hassdenteufel, Kathrin, Gutsfeld, Raphael, Müller, Mitho, Goetz, Maren, Bauer, Armin, Wallwiener, Markus, Brucker, Sara Y., Joos, Stefanie, Colombo, Miriam Giovanna, Hawighorst‑Knapstein, Sabine, Chaudhuri, Ariane, Beck, Frauke, Wallwiener, Stephanie

“…Preeclampsia is associated with a substantially increased long-term risk for cardiovascular, cerebrovascular and renal disease. It remains unclear whether and…”
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Health economic evaluation of an electronic mindfulness-based intervention (eMBI) to improve maternal mental health during pregnancy – a randomized controlled trial (RCT) by Hasemann, Lena, Elkenkamp, Svenja, Müller, Mitho, Bauer, Armin, Wallwiener, Stephanie, Greiner, Wolfgang

“…Background Anxiety and depression are the most prevalent psychiatric diseases in the peripartum period. They can lead to relevant health consequences for…”
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Effectiveness and cost-effectiveness of an electronic mindfulness-based intervention (eMBI) on maternal mental health during pregnancy: the mindmom study protocol for a randomized controlled clinical trial by Müller, Mitho, Matthies, Lina Maria, Goetz, Maren, Abele, Harald, Brucker, Sara Yvonne, Bauer, Armin, Graf, Johanna, Zipfel, Stephan, Hasemann, Lena, Wallwiener, Markus, Wallwiener, Stephanie

“…Abstract Background Mental disorders are common during the peripartum period and may have far-reaching consequences for both mother and child. Unfortunately,…”
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Armeniaspiroles, a new class of antibacterials: antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A by Couturier, Cédric, Bauer, Armin, Rey, Astrid, Schroif-Dufour, Cosima, Broenstrup, Mark

“…Armeniaspiroles, a novel class of natural products isolated from Streptomyces armeniacus, are characterized by a novel spiro[4.4]non-8-ene scaffold. Various…”
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An observational claims data analysis on the risk of maternal chronic kidney disease after preterm delivery and preeclampsia by Goetz, Maren, Müller, Mitho, Gutsfeld, Raphael, Dijkstra, Tjeerd, Hassdenteufel, Kathrin, Brucker, Sara Yvonne, Bauer, Armin, Joos, Stefanie, Colombo, Miriam Giovanna, Hawighorst-Knapstein, Sabine, Chaudhuri, Ariane, Kirtschig, Gudula, Saalmann, Frauke, Wallwiener, Stephanie

“…Women with complications of pregnancy such as preeclampsia and preterm birth are at risk for adverse long-term outcomes, including an increased future risk of…”
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The BrEasT cancer afTER-CARE (BETTER-CARE) programme to improve breast cancer follow-up: design and feasibility study results of a cluster-randomised complex intervention trial by Horn, Anna, Wendel, Julia, Franke, Isabella, Bauer, Armin, Baumeister, Harald, Bendig, Eileen, Brucker, Sara Y., Deutsch, Thomas M., Garatva, Patricia, Haas, Kirsten, Heil, Lorenz, Hügen, Klemens, Manger, Helena, Pryss, Rüdiger, Rücker, Viktoria, Salmen, Jessica, Szczesny, Andrea, Vogel, Carsten, Wallwiener, Markus, Wöckel, Achim, Heuschmann, Peter U., Ast, Alexander, Belke, Kerstin, Beurer, Björn, Bolkenius, Petra, Freese, Kristina, Frumkin, Nora, Gnauert, Karsten, Graf, Heiko, Hackmann, John, Hartmann, Corinna, Hesse, Tobias, Hopp, Melanie, Keil, Elke, Lehnert, Antje, Müller, Cordula, Mundhenke, Christoph, Niestroj, Hue Phan, Nixdorf, Antje, Pankert, Kilian, Perez, Sibylle, Radosa, Julia, Rezek, Daniela, Seldte, Jens-Paul, Stalzer, Gabriele, Sykorova, Zuzana, Tenger, Martin, Volmer, Léa, Würfel, Katharina, Zorr, Andreas

“…Abstract Background The risk of breast cancer patients for long-term side effects of therapy such as neurotoxicity and cardiotoxicity as well as late effects…”
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Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products by Brinkmann, Stephan, Kurz, Michael, Patras, Maria A, Hartwig, Christoph, Marner, Michael, Leis, Benedikt, Billion, André, Kleiner, Yolanda, Bauer, Armin, Toti, Luigi, Pöverlein, Christoph, Hammann, Peter E, Vilcinskas, Andreas, Glaeser, Jens, Spohn, Marius, Schäberle, Till F

“…With progress in genome sequencing and data sharing, 1,000s of bacterial genomes are publicly available. Genome mining-using bioinformatics tools in terms of…”
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Total Synthesis of Floyocidin B: 4,5-Regioselective Functionalization of 2-Chloropyridines by Kleiner, Yolanda, Bauer, Armin, Hammann, Peter, Schuler, Sören M. M., Pöverlein, Christoph

“…The recently discovered natural product (NP) (+)-floyocidin B with antimicrobial activity against Mycobacterium tuberculosis displays a hitherto unknown…”
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Novel workflow analysis of robot-assisted hysterectomy through objective performance indicators: a pilot study by Neis, Felix, Brucker, Sara Yvonne, Bauer, Armin, Shields, Mallory, Purvis, Lilia, Liu, Xi, Ershad, Marzieh, Walter, Christina Barbara, Dijkstra, Tjeerd, Reisenauer, Christl, Kraemer, Bernhard

“…The curriculum for a da Vinci surgeon in gynecology requires special training before a surgeon performs their first independent case, but standardized,…”
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Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens by Schuler, Sören M M, Jürjens, Gerrit, Marker, Alexander, Hemmann, Ulrike, Rey, Astrid, Yvon, Stéphane, Lagrevol, Marjorie, Hamiti, Mohamed, Nguyen, Fabian, Hirsch, Rolf, Pöverlein, Christoph, Vilcinskas, Andreas, Hammann, Peter, Wilson, Daniel N, Mourez, Michael, Coyne, Sebastien, Bauer, Armin

“…After the first total synthesis combined with structure revision, we performed thorough and profiling of the underexplored tetrapeptide GE81112A. From the…”
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Micrococcin P1 – A bactericidal thiopeptide active against Mycobacterium tuberculosis by Degiacomi, Giulia, Personne, Yoann, Mondésert, Guillaume, Ge, Xueliang, Mandava, Chandra Sekhar, Hartkoorn, Ruben C, Boldrin, Francesca, Goel, Pavitra, Peisker, Kristin, Benjak, Andrej, Barrio, Maria Belén, Ventura, Marcello, Brown, Amanda C, Leblanc, Véronique, Bauer, Armin, Sanyal, Suparna, Cole, Stewart T, Lagrange, Sophie, Parish, Tanya, Manganelli, Riccardo

“…Summary The lack of proper treatment for serious infectious diseases due to the emergence of multidrug resistance reinforces the need for the discovery of…”
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Antimicrobial Peptides from Rat-Tailed Maggots of the Drone Fly Eristalis tenax Show Potent Activity against Multidrug-Resistant Gram-Negative Bacteria by Hirsch, Rolf, Wiesner, Jochen, Bauer, Armin, Marker, Alexander, Vogel, Heiko, Hammann, Peter Eugen, Vilcinskas, Andreas

“…The spread of multidrug-resistant Gram-negative bacteria is an increasing threat to human health, because novel compound classes for the development of…”
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Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold:  A Study Combining Structure-Activity Relationship and X-ray Crystallography by Nazaré, Marc, Will, David W, Matter, Hans, Schreuder, Herman, Ritter, Kurt, Urmann, Matthias, Essrich, Melanie, Bauer, Armin, Wagner, Michael, Czech, Jörg, Lorenz, Martin, Laux, Volker, Wehner, Volkmar

“…Structure−activity relationships within a series of highly potent 2-carboxyindole-based factor Xa inhibitors incorporating a neutral P1 ligand are described…”
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Profiling antimicrobial peptides from the medical maggot Lucilia sericata as potential antibiotics for MDR Gram-negative bacteria by Hirsch, Rolf, Wiesner, Jochen, Marker, Alexander, Pfeifer, Yvonne, Bauer, Armin, Hammann, Peter E, Vilcinskas, Andreas

“…Abstract Background The ability of MDR Gram-negative bacteria to evade even antibiotics of last resort is a severe global challenge. The development pipeline…”
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Svetamycins A–G, Unusual Piperazic Acid-Containing Peptides from Streptomyces sp by Dardić, Denis, Lauro, Gianluigi, Bifulco, Giuseppe, Laboudie, Patricia, Sakhaii, Peyman, Bauer, Armin, Vilcinskas, Andreas, Hammann, Peter E, Plaza, Alberto

“…Seven new halogenated peptides termed svetamycins A–G (1–7) have been isolated from laboratory cultures of a Streptomyces sp. Svetamycins A–D, F, and G are…”
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Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties by Hoffmann, Holger, Kogler, Herbert, Heyse, Winfried, Matter, Hans, Caspers, Michael, Schummer, Dietmar, Klemke-Jahn, Christine, Bauer, Armin, Penarier, Geraldine, Debussche, Laurent, Brönstrup, Mark

“…Microbial natural products are a rich source of bioactive molecules to serve as drug leads and/or biological tools. We investigated a little‐explored…”
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