Search Results - "Batzler, A"

TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics by Gupta, M, Neavin, D, Liu, D, Biernacka, J, Hall-Flavin, D, Bobo, W V, Frye, M A, Skime, M, Jenkins, G D, Batzler, A, Kalari, K, Matson, W, Bhasin, S S, Zhu, H, Mushiroda, T, Nakamura, Y, Kubo, M, Wang, L, Kaddurah-Daouk, R, Weinshilboum, R M

“…Millions of patients suffer from major depressive disorder (MDD), but many do not respond to selective serotonin reuptake inhibitor (SSRI) therapy. We used a…”
Get full text

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response by Biernacka, J M, Sangkuhl, K, Jenkins, G, Whaley, R M, Barman, P, Batzler, A, Altman, R B, Arolt, V, Brockmöller, J, Chen, C H, Domschke, K, Hall-Flavin, D K, Hong, C J, Illi, A, Ji, Y, Kampman, O, Kinoshita, T, Leinonen, E, Liou, Y J, Mushiroda, T, Nonen, S, Skime, M K, Wang, L, Baune, B T, Kato, M, Liu, Y L, Praphanphoj, V, Stingl, J C, Tsai, S J, Kubo, M, Klein, T E, Weinshilboum, R

“…Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably between patients. The International SSRI Pharmacogenomics…”
Get full text

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics by Ji, Y, Biernacka, J M, Hebbring, S, Chai, Y, Jenkins, G D, Batzler, A, Snyder, K A, Drews, M S, Desta, Z, Flockhart, D, Mushiroda, T, Kubo, M, Nakamura, Y, Kamatani, N, Schaid, D, Weinshilboum, R M, Mrazek, D A

“…A genome-wide association (GWA) study of treatment outcomes (response and remission) of selective serotonin reuptake inhibitors (SSRIs) was conducted using 529…”
Get full text

Leveraging electronic health records to study pleiotropic effects on bipolar disorder and medical comorbidities by Prieto, M L, Ryu, E, Jenkins, G D, Batzler, A, Nassan, M M, Cuellar-Barboza, A B, Pathak, J, McElroy, S L, Frye, M A, Biernacka, J M

“…Patients with bipolar disorder (BD) have a high prevalence of comorbid medical illness. However, the mechanisms underlying these comorbidities with BD are not…”
Get full text

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response by Biernacka, J M, Sangkuhl, K, Jenkins, G, Whaley, R M, Barman, P, Batzler, A, Altman, R B, Arolt, V, Brockmöller, J, Chen, C H, Domschke, K, Hall-Flavin, D K, Hong, C J, Illi, A, Ji, Y, Kampman, O, Kinoshita, T, Leinonen, E, Liou, Y J, Mushiroda, T, Nonen, S, Skime, M K, Wang, L, Baune, B T, Kato, M, Liu, Y L, Praphanphoj, V, Stingl, J C, Tsai, S J, Kubo, M, Klein, T E, Weinshilboum, R

Get full text

Erratum: The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response by Biernacka, J M, Sangkuhl, K, Jenkins, G, Whaley, R M, Barman, P, Batzler, A, Altman, R B, Arolt, V, Brockmöller, J, Chen, C H, Domschke, K, Hall-Flavin, D K, Hong, C J, Illi, A, Ji, Y, Kampman, O, Kinoshita, T, Leinonen, E, Liou, Y J, Mushiroda, T, Nonen, S, Skime, M K, Wang, L, Baune, B T, Kato, M, Liu, Y L, Praphanphoj, V, Stingl, J C, Tsai, S J, Kubo, M, Klein, T E, Weinshilboum, R

“…Correction to: Translational Psychiatry (2015) 5, e553; doi:10.1038/tp.2015.47; published online 21 April 2015 Following publication, the authors identified an…”
Get full text

Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics by Fridley, B L, Jenkins, G D, Batzler, A, Wang, L, Ji, Y, Li, F, Weinshilboum, R M

“…Often, analysis for pharmacogenomic studies involving multiple drugs from the same class is completed by analyzing each drug individually for association with…”
Get full text

A hundred things she's not by Batzler, L. A.

“…A million ways my heart can break this year…”
Get full text

Genome-wide interactions with body mass index and bipolar disorder risk: a study from the psychiatric genomics consortium bipolar disorder working group by Winham, S., Cuellar Barboza, A., Batzler, A., Adolfsson, Rolf, Alda, M., Andreassen, O., Di Florio, A., Forstner, A., Kelsoe, J., Landen, M., Vincent, J., McElroy, S., Frye, M., Biernacka, J.

Get full text

Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics by Abo, Ryan, Hebbring, Scott, Ji, Yuan, Zhu, Hongjie, Zeng, Zhao-Bang, Batzler, Anthony, Jenkins, Gregory D, Biernacka, Joanna, Snyder, Karen, Drews, Maureen, Fiehn, Oliver, Fridley, Brooke, Schaid, Daniel, Kamatani, Naoyuki, Nakamura, Yusuke, Kubo, Michiaki, Mushiroda, Taisei, Kaddurah-Daouk, Rima, Mrazek, David A, Weinshilboum, Richard M

“…OBJECTIVEWe set out to test the hypothesis that pharmacometabolomic data could be efficiently merged with pharmacogenomic data by single-nucleotide…”
Get full text

Increased risk of hospitalization for ultrarapid metabolizers of cytochrome P450 2D6 by Takahashi, Paul Y, Ryu, Euijung, Pathak, Jyotishman, Jenkins, Gregory D, Batzler, Anthony, Hathcock, Matthew A, Black, John Logan, Olson, Janet E, Cerhan, James R, Bielinski, Suzette J

“…Cytochrome P450 2D6 ( ) is responsible for the metabolism of clinically used drugs and other environmental exposures, but it is unclear whether the phenotype…”
Get full text

Identification of a novel percent mammographic density locus at 12q24 by STEVENS, Kristen N, LINDSTROM, Sara, VARGHESE, Jajini S, AUDLEY, Tina, BROWN, Judith, LEYLAND, Jean, LUBEN, Robert N, WARREN, Ruth M. L, LOOS, Ruth J. F, WAREHAM, Nicholas J, JINGMEI LI, HALL, Per, SCOTT, Christopher G, JIANJUN LIU, ERIKSSON, Louise, CZENE, Kamila, OLSON, Janet E, PANKRATZ, V. Shane, FREDERICKSEN, Zachary, DIASIO, Robert B, LEE, Adam M, HEIT, John A, DEANDRADE, Mariza, THOMPSON, Deborah, GOODE, Ellen L, VIERKANT, Robert A, CUNNINGHAM, Julie M, ARMASU, Sebastian M, WEINSHILBOUM, Richard, FRIDLEY, Brooke L, BATZLER, Anthony, INGLE, James N, BOYD, Norman F, PATERSON, Andrew D, SELLERS, Thomas A, ROMMENS, Johanna, MARTIN, Lisa J, HOPPER, John L, SOUTHEY, Melissa C, STONE, Jennifer, APICELLA, Carmel, KRAFT, Peter, HANKINSON, Susan E, HAZRA, Aditi, HUNTER, David J, XIANSHU WANG, EASTON, Douglas F, COUCH, Fergus J, TAMIMI, Rulla M, VACHON, Celine M, WANG, Alice, ATKINSON, Elizabeth, RIDER, David N, ECKEL-PASSOW, Jeanette E

“…Percent mammographic density adjusted for age and body mass index (BMI) is one of the strongest risk factors for breast cancer and has a heritable component…”
Get full text

Exact Tests of Hardy-Weinberg Equilibrium and Homogeneity of Disequilibrium across Strata by Schaid, Daniel J., Batzler, Anthony J., Jenkins, Gregory D., Hildebrandt, Michelle A.T.

“…Detecting departures from Hardy-Weinberg equilibrium (HWE) of marker-genotype frequencies is a crucial first step in almost all human genetic analyses. When a…”
Get full text

Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis by Chalise, Prabhakar, Batzler, Anthony, Abo, Ryan, Wang, Liewei, Fridley, Brooke L

“…Variation in drug response results from a combination of factors that include differences in gender, ethnicity, and environment, as well as genetic variation…”
Get more information

A Genome-Wide Association Study in Patients Experiencing Musculoskeletal Adverse Events on Aromatase Inhibitors as Adjuvant Therapy in Early Breast Cancer Entered on NCIC CTG Trial MA.27. A Pharmacogenetics Research Network-RIKEN Collaboration by Ingle, J., Schaid, D., Goss, P., Mushiroda, T., Chapman, J., Kubo, M., Jenkins, G., Batzler, A., Liu, M., Shepherd, L., Ellis, M., Flockhart, D., Nakamura, Y., Weinshilboum, R.

“…Abstract Background: The third-generation aromatase inhibitors (AIs) are established adjuvant therapy for postmenopausal women with early stage breast cancer…”
Get full text

Genes regulating estradiol and estrone-conjugate levels in postmenopausal women with resected early-stage breast cancer detected by a genome-wide association study (GWAS) by Ingle, J. N., Fridley, B. L., Buzdar, A., Robson, M. E., Kubo, M., Liu, M., Ibrahim-Zada, I., Batzler, A., Jenkins, G. D., Goetz, M. P., Northfelt, D. W., Perez, E. A., Williard, C. V., Wang, L., Schaid, D. J., Nakamura, Y., Weinshilboum, R. M.

“…Abstract only…”
Get full text

Abstract PD05-02: Genome-Wide Associations of Breast Events and Functional Genomic Studies in High-Risk Women Receiving Tamoxifen or Raloxifene on NSABP P1 and P2 Prevention Trials. A Pharmacogenomics Research Network-RIKEN-NSABP Collaboration by Ingle, JN, Liu, M, Wickerham, DL, Schaid, DJ, Mushiroda, T, Kubo, M, Costantino, JP, Goetz, MP, Ames, MM, Wang, L, Vogel, VG, Paik, S, Batzler, A, Flockhart, DA, Wolmark, N, Nakamura, Y, Weinshilboum, R.

“…Abstract Background: NSABP P1 and P2 are the largest prevention trials of tamoxifen and raloxifene in women at high risk of developing breast cancer. Both…”
Get full text