Search Results - "Batuello, Christopher N."

Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase by Batuello, Christopher N., Hauck, Paula M., Gendron, Jaimie M., Lehman, Jason A., Mayo, Lindsey D.

“…Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor…”
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Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes by Lehman, Jason A, Hauck, Paula M, Gendron, Jaimie M, Batuello, Christopher N, Eitel, Jacob A, Albig, Allan, Kadakia, Madhavi P, Mayo, Lindsey D

“…Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also…”
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Role of Ape1 and Base Excision Repair in the Radioresponse and Heat-radiosensitization of HeLa Cells by Batuello, Christopher N, Kelley, Mark R, Dynlacht, Joseph R

“…Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair…”
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Controlling the Mdm2-Mdmx-p53 Circuit by Waning, David L, Lehman, Jason A, Batuello, Christopher N, Mayo, Lindsey D

“…The p53 tumor suppressor is a key protein in maintaining the integrity of the genome by inducing either cell cycle arrest or apoptosis following cellular…”
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TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer by Araki, Shinako, Eitel, Jacob A, Batuello, Christopher N, Bijangi-Vishehsaraei, Khadijeh, Xie, Xian-Jin, Danielpour, David, Pollok, Karen E, Boothman, David A, Mayo, Lindsey D

“…The E3 ubiquitin ligase human murine double minute (HDM2) is overexpressed in 40%-80% of late-stage metastatic cancers in the absence of gene amplification…”
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Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function by Hauck, Paula M, Wolf, Eric R, Olivos, 3rd, David J, Batuello, Christopher N, McElyea, Kyle C, McAtarsney, Ciarán P, Cournoyer, R Michael, Sandusky, George E, Mayo, Lindsey D

“…Metastasis of cancer cells to distant organ systems is a complex process that is initiated with the programming of cells in the primary tumor. The formation of…”
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Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model by Tonsing-Carter, Eva, Bailey, Barbara J, Saadatzadeh, M Reza, Ding, Jixin, Wang, Haiyan, Sinn, Anthony L, Peterman, Kacie M, Spragins, Tiaishia K, Silver, Jayne M, Sprouse, Alyssa A, Georgiadis, Taxiarchis M, Gunter, T Zachary, Long, Eric C, Minto, Robert E, Marchal, Christophe C, Batuello, Christopher N, Safa, Ahmad R, Hanenberg, Helmut, Territo, Paul R, Sandusky, George E, Mayo, Lindsey D, Eischen, Christine M, Shannon, Harlan E, Pollok, Karen E

“…Triple-negative breast cancers (TNBC) are typically resistant to treatment, and strategies that build upon frontline therapy are needed. Targeting the murine…”
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c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation by Waning, David L., Lehman, Jason A., Batuello, Christopher N., Mayo, Lindsey D.

“…Mdm2 and Mdmx are oncoproteins that have essential yet nonredundant roles in development and function as part of a multicomponent ubiquitinating complex that…”
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Induction of Apoptotic Genes by a p73-Phosphatase and Tensin Homolog (p73-PTEN) Protein Complex in Response to Genotoxic Stress by Lehman, Jason A., Waning, David L., Batuello, Christopher N., Cipriano, Rocky, Kadakia, Madhavi P., Mayo, Lindsey D.

“…The p53 family member, p73, has been characterized as a tumor suppressor and functions in a similar manner as p53 to induce cellular death. The phosphatase and…”
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Identification of Mre11 as a Target for Heat Radiosensitization by Dynlacht, Joseph R., Batuello, Christopher N., Lopez, Jennifer T., Kim, Kyung Keun, Turchi, John J.

“…Thermal radiosensitization is believed to be mediated by an inhibition of double-strand break (DSB) repair, but the exact mechanism of radiosensitization…”
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Effect of Gender on Radiation-Induced Cataractogenesis by Henderson, Mark A., Valluri, Shailaja, DesRosiers, Colleen, Lopez, Jennifer T., Batuello, Christopher N., Caperell-Grant, Andrea, Mendonca, Marc S., Powers, Eva-Marie, Bigsby, Robert M., Dynlacht, Joseph R.

“…Henderson, M. A., Valluri, S., DesRosiers, C., Lopez, J. T., Batuello, C. N., Caperell-Grant, A., Mendonca, M. S., Powers, E., Bigsby, R. M. and Dynlacht, J…”
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Early Stage Metastasis Require Mdm2 and not p53 Gain of Function by Hauck, Paula M., Wolf, Eric R., Olivos, David J., Batuello, Christopher N., McElyea, Kyle C., McAtarsney, Ciaran, Cournoyer, R. Michael, Sandusky, George E., Mayo, Lindsey D.

“…Metastasis of cancer cells to distant organ systems is a complex process that is initiated with the programming of cells in the primary tumor. The formation of…”
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Serdemetan Antagonizes the Mdm2-HIF1[alpha] Axis Leading to Decreased Levels of Glycolytic Enzymes by Lehman, Jason A, Hauck, Paula M, Gendron, Jaimie M, Batuello, Christopher N, Eitel, Jacob A, Albig, Allan, Kadakia, Madhavi P, Mayo, Lindsey D

“…Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also…”
Get full text

Role of Ape1 and Base Excision Repair in the Radiation Response and Heat-radiosensitization of HeLa Cells by Batuello, Christopher N., Kelley, Mark R., Dynlacht, Joseph R.

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Role of Apel and Base Excision Repair in the Radioresponse and Heat-radiosensitization of HeLa Cells by BATUELLO, Christopher N, KELLEY, Mark R, DYNLACHT, Joseph R

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TGF-[beta]1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer by Araki, Shinako, Eitel, Jacob A, Batuello, Christopher N, Bijangi-Vishehsaraei, Khadijeh, Xie, Xian-Jin, Danielpour, David, Pollok, Karen E, Boothman, David A, Mayo, Lindsey D

“…The E3 ubiquitin ligase human murine double minute (HDM2) is overexpressed in 40%-80% of late-stage metastatic cancers in the absence of gene amplification…”
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Phospho-regulation and metastatic potential of murine double minute 2 by Batuello, Christopher N

“…Murine double minute (Mdm2) is a highly modified and multi-faceted protein that is overexpressed in numerous human malignancies. It engages in many cellular…”
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TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer by Araki, Shinako, Eitel, Jacob A, Batuello, Christopher N, Bijangi-Vishehsaraei, Khadijeh, Xie, Xian-Jin, Danielpour, David, Pollok, Karen E, Boothman, David A, Mayo, Lindsey D

“…The E3 ubiquitin ligase human murine double minute (HDM2) is overexpressed in 40%-80% of late-stage metastatic cancers in the absence of gene amplification…”
Get full text