Search Results - "Battisti, Umberto"

Synergistic Experimental and Computational Investigation of the Bioorthogonal Reactivity of Substituted Aryltetrazines by Battisti, Umberto M, García-Vázquez, Rocío, Svatunek, Dennis, Herrmann, Barbara, Löffler, Andreas, Mikula, Hannes, Herth, Matthias Manfred

“…Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications, including pretargeted imaging approaches. In radioimmunoimaging,…”
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Comparison of Different Organometallics Towards Electrophilic Aromatic 211At-Astatinations of Highly Reactive Tetrazines by Poulie, Christian B M, Muller, Marius, Bom Pedersen, Nadia, Martin, Marcel, Mühlbauer, Valerie, Matiussi, Simona, Jensen, Holger, Herth, Matthias, Battisti, Umberto Maria

“…Organometallics can be used as precursors for electrophilic 211At-statinations. In this report, we compared the potential of aryl trimethylsilanes, -germanes,…”
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Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging by García-Vázquez, Rocío, Battisti, Umberto, Herth, Matthias

“…Tetrazine ligation has gained interest as a bio-orthogonal chemistry tool within the last decade. In nuclear medicine, tetrazine ligation is currently being…”
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Development of the First Aliphatic 18 F-Labeled Tetrazine Suitable for Pretargeted PET Imaging-Expanding the Bioorthogonal Tool Box by Battisti, Umberto M, Bratteby, Klas, Jørgensen, Jesper T, Hvass, Lars, Shalgunov, Vladimir, Mikula, Hannes, Kjær, Andreas, Herth, Matthias Manfred

“…Pretargeted imaging of nanomedicines have attracted considerable interest because it has the potential to increase imaging contrast while reducing radiation…”
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Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine by Shalgunov, Vladimir, van den Broek, Sara Lopes, Andersen, Ida Vang, Raval, Nakul R., Schäfer, Gabriela, Barz, Matthias, Herth, Matthias M., Battisti, Umberto M.

“…Brain pretargeted nuclear imaging for the diagnosis of various neurodegenerative diseases is a quickly developing field. The tetrazine ligation is currently…”
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Analytical and preparative enantioseparation and main chiroptical properties of Iridium(III) bis(4,6-difluorophenylpyridinato)picolinato by Citti, Cinzia, Battisti, Umberto M., Ciccarella, Giuseppe, Maiorano, Vincenzo, Gigli, Giuseppe, Abbate, Sergio, Mazzeo, Giuseppe, Castiglioni, Ettore, Longhi, Giovanna, Cannazza, Giuseppe

“…•A convenient method is presented for the direct separation of enantiomers of fac-trans-N–N, bis[2-(4,6-difluorophenyl)pyridinato-C2,N](picolinato)iridium(III)…”
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Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca2+ channels as sensors by Ruchala, Iwona, Battisti, Umberto M., Nguyen, Vy T., Chen, Rita Yu-Tzu, Glennon, Richard A., Eltit, Jose M.

“…The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic…”
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Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry by Stéen, E. Johanna L, Jørgensen, Jesper T, Denk, Christoph, Battisti, Umberto M, Nørregaard, Kamilla, Edem, Patricia E, Bratteby, Klas, Shalgunov, Vladimir, Wilkovitsch, Martin, Svatunek, Dennis, Poulie, Christian B. M, Hvass, Lars, Simón, Marina, Wanek, Thomas, Rossin, Raffaella, Robillard, Marc, Kristensen, Jesper L, Mikula, Hannes, Kjaer, Andreas, Herth, Matthias M

“…The development of highly selective and fast biocompatible reactions for ligation and cleavage has paved the way for new diagnostic and therapeutic…”
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Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists by Franchini, Silvia, Manasieva, Leda Ivanova, Sorbi, Claudia, Battisti, Umberto M., Fossa, Paola, Cichero, Elena, Denora, Nunzio, Iacobazzi, Rosa Maria, Cilia, Antonio, Pirona, Lorenza, Ronsisvalle, Simone, Aricò, Giuseppina, Brasili, Livio

“…Recently, 1-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)-4-(2-methoxyphenyl)piperazine (1) was reported as a potent 5-HT1AR agonist with a moderate 5-HT1AR selectivity…”
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Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase by Battisti, Umberto Maria, Gao, Chunxia, Nilsson, Oscar, Akladios, Fady, Lulla, Aleksei, Bogucka, Agnieszka, Nain‐Perez, Amalyn, Håversen, Liliana, Kim, Woonghee, Boren, Jan, Hyvönen, Marko, Uhlen, Mathias, Mardinoglu, Adil, Grøtli, Morten

“…Enzymes are effective biological catalysts that accelerate almost all metabolic reactions in living organisms. Synthetic modulators of enzymes are useful tools…”
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Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase by Battisti, Umberto Maria, Monjas, Leticia, Akladios, Fady, Matic, Josipa, Andresen, Eric, Nagel, Carolin H, Hagkvist, Malin, Håversen, Liliana, Kim, Woonghee, Uhlen, Mathias, Borén, Jan, Mardinoğlu, Adil, Grøtli, Morten

“…The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in…”
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Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase by Battisti, Umberto Maria, Gao, Chunixa, Akladios, Fady, Kim, Woonghee, Yang, Hong, Bayram, Cemil, Bolat, Ismail, Kiliclioglu, Metin, Yuksel, Nursena, Tozlu, Ozlem Ozdemir, Zhang, Cheng, Sebhaoui, Jihad, Iqbal, Shazia, Shoaie, Saeed, Hacimuftuoglu, Ahmet, Yildirim, Serkan, Turkez, Hasan, Uhlen, Mathias, Boren, Jan, Mardinoglu, Adil, Grøtli, Morten

“…Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent a…”
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Direct Cu-mediated aromatic 18 F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging by García-Vázquez, Rocío, Battisti, Umberto M, Jørgensen, Jesper T, Shalgunov, Vladimir, Hvass, Lars, Stares, Daniel L, Petersen, Ida N, Crestey, François, Löffler, Andreas, Svatunek, Dennis, Kristensen, Jesper L, Mikula, Hannes, Kjaer, Andreas, Herth, Matthias M

“…Pretargeted imaging can be used to visualize and quantify slow-accumulating targeting vectors with short-lived radionuclides such as fluorine-18 - the most…”
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Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging by García-Vázquez, Rocío, Battisti, Umberto M, Jørgensen, Jesper T, Shalgunov, Vladimir, Hvass, Lars, Stares, Daniel L, Petersen, Ida N, Crestey, François, Löffler, Andreas, Svatunek, Dennis, Kristensen, Jesper L, Mikula, Hannes, Kjaer, Andreas, Herth, Matthias M

“…Pretargeted imaging can be used to visualize and quantify slow-accumulating targeting vectors with short-lived radionuclides such as fluorine-18 – the most…”
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET by Schlein, Eva, Rokka, Johanna, Odell, Luke R., van den Broek, Sara Lopes, Herth, Matthias M., Battisti, Umberto M., Syvänen, Stina, Sehlin, Dag, Eriksson, Jonas

“…Background The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based…”
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A Fluorescent Probe as a Lead Compound for a Selective α‑Synuclein PET Tracer: Development of a Library of 2‑Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB by Di Nanni, Adriana, Saw, Ran Sing, Battisti, Umberto M., Bowden, Gregory D., Boeckermann, Adam, Bjerregaard-Andersen, Kaare, Pichler, Bernd J., Herfert, Kristina, Herth, Matthias M., Maurer, Andreas

“…A method to detect and quantify aggregated α-synuclein (αSYN) fibrils in vivo would drastically impact the current understanding of multiple neurodegenerative…”
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Development of an in vitro liquid chromatography–mass spectrometry method to evaluate stereo and chemical stability of new drug candidates employing immobilized artificial membrane column by Cannazza, Giuseppe, Battisti, Umberto M., Carrozzo, Marina M., Cazzato, Addolorata S., Braghiroli, Daniela, Parenti, Carlo, Troisi, Luigino

“…•A method to evaluate stability of chiral compounds in gastrointestinal simulated fluids is reported.•The use of an IAM column confirm the influence of a…”
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“Heart-cut” bidimensional achiral-chiral liquid chromatography applied to the evaluation of stereoselective metabolism, in vivo biological activity and brain response to chiral drug candidates targeting the central nervous system by Battisti, Umberto M., Citti, Cinzia, Larini, Martina, Ciccarella, Giuseppe, Stasiak, Natalia, Troisi, Luigino, Braghiroli, Daniela, Parenti, Carlo, Zoli, Michele, Cannazza, Giuseppe

“…•A method to evaluate simultaneously in vivo biological activity and brain response to chiral drug candidates targeting the central nervous system is…”
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Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts by Korat, Špela, Bidesi, Natasha Shalina Rajani, Bonanno, Federica, Di Nanni, Adriana, Hoàng, Anh Nguyên Nhât, Herfert, Kristina, Maurer, Andreas, Battisti, Umberto Maria, Bowden, Gregory David, Thonon, David, Vugts, Daniëlle, Windhorst, Albert Dirk, Herth, Matthias Manfred

“…Neurodegenerative diseases such as Parkinson’s disease (PD) are manifested by inclusion bodies of alpha-synuclein (α-syn) also called α-synucleinopathies…”
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Optimization of Direct Aromatic 18F-Labeling of Tetrazines by Andersen, Ida Vang, García-Vázquez, Rocío, Battisti, Umberto Maria, Herth, Matthias M.

“…Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide…”
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