Search Results - "Battella, Simone"
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CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis
Published in Cancer Immunology, Immunotherapy (01-04-2020)“…Obinutuzumab is a glycoengineered tumor-targeting anti-CD20 mAb with a modified crystallizable fragment (Fc) domain designed to increase the affinity for the…”
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Memory NK Cell Features Exploitable in Anticancer Immunotherapy
Published in Journal of immunology research (01-01-2019)“…Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong…”
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Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming
Published in Frontiers in immunology (11-05-2018)“…Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity…”
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Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production
Published in Oncoimmunology (04-03-2017)“…Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity…”
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Corrigendum: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature
Published in Frontiers in immunology (02-05-2023)“…[This corrects the article DOI: 10.3389/fimmu.2023.1043631.]…”
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Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature
Published in Frontiers in immunology (14-02-2023)“…Effective secondary response to antigen is a hallmark of immunological memory. However, the extent of memory CD8 T cell response to secondary boost varies at…”
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A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition
Published in PLoS pathogens (01-03-2013)“…The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no…”
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(Auto)Antibody Responses Shape Memory NK Cell Pool Size and Composition
Published in Biomedicines (08-03-2022)“…In vivo establishment and long-term persistence of a heterogeneous memory or an adaptive NK cell pool represents a functional adaptation to human…”
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Safety and immune response kinetics of GRAd-COV2 vaccine: phase 1 clinical trial results
Published in npj vaccines (24-09-2022)“…Despite the successful deployment of efficacious vaccines and therapeutics, the development of novel vaccines for SARS-CoV-2 remains a major goal to increase…”
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Natural killer (NK) cells and anti‐tumor therapeutic mAb: unexplored interactions
Published in Journal of leukocyte biology (01-01-2016)“…Review of interactions between NK cells and therapeutic tumor‐targeting mAbs, and development of novel NK cell‐based strategies for cancer treatment…”
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Harnessing CD16-Mediated NK Cell Functions to Enhance Therapeutic Efficacy of Tumor-Targeting mAbs
Published in Cancers (20-05-2021)“…Natural killer (NK) cells hold a pivotal role in tumor-targeting monoclonal antibody (mAb)-based activity due to the expression of CD16, the low-affinity…”
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The peripheral blood compartment of patients with Diffuse Large B Cell Lymphoma (DLBCL) at diagnosis is characterized by distinct phenotypic and functional Immunological alterations
Published in Frontiers in immunology (2013)“…Abstract only…”
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Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19
Published in Molecular therapy (04-08-2021)“…The coronavirus disease 2019 (COVID-19) pandemic caused by the emergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public…”
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Regulation and trafficking of the HLA‐E molecules during monocyte‐macrophage differentiation
Published in Journal of leukocyte biology (01-01-2016)“…HLA‐E molecules undergo an alternative pathway of intracellular trafficking in monocyte‐derived macrophages. HLA‐E is a nonclassical HLA‐class I molecule whose…”
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GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults
Published in Science translational medicine (12-01-2022)“…Safe and effective vaccines against coronavirus disease 2019 (COVID-19) are essential for ending the ongoing pandemic. Although impressive progress has been…”
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T lymphocytes engineered to express a CD16-chimeric antigen receptor redirect T-cell immune responses against immunoglobulin G–opsonized target cells
Published in Cytotherapy (Oxford, England) (01-02-2016)“…Abstract Background aims Chimeric antigen receptors (CARs) designed for adoptive immunotherapy need to achieve two functions: antigen recognition and…”
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Effect of surgery on pancreatic tumor-dependent lymphocyte asset: modulation of natural killer cell frequency and cytotoxic function
Published in Pancreas (01-04-2015)“…Tumor burden and invasiveness establish a microenvironment that surgery could alter. This study shows a comprehensive analysis of size, dynamics, and function…”
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Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy
Published in Cancer Immunology, Immunotherapy (01-10-2017)“…The importance of T cell-dependent immune responses in achieving long-term cure of chemoimmunotherapy-treated cancer patients is underscored by the recently…”
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Phenotypically and Functionally Altered T Cell Compartment in DLBCL Patients at Diagnosis and Its Long-Term Modification upon Chemoimmunotherapy Regimen
Published in Blood (03-12-2015)“…Background: Peripheral blood lymphopenia at diagnosis and after treatment has been widely reported as a negative prognostic factor in DLBCL. This phenomenon,…”
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Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients
Published in Oncoimmunology (01-03-2015)“…Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing of lymphoma cells via…”
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