Search Results - "Batt, D G"

Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep by Stremming, J, White, A, Donthi, A, Batt, D G, Hetrick, B, Chang, E I, Wesolowski, S R, Seefeldt, M B, McCurdy, C E, Rozance, P J, Brown, L D

“…IGF-1 is a critical fetal growth-promoting hormone. Experimental infusion of an IGF-1 analog, human recombinant LR3 IGF-1, into late gestation fetal sheep…”
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Synthesis of Cis and Trans Isomers of an Isoxazoline Ring-Hydroxylated Metabolite of Roxifiban, a Platelet Glycoprotein IIb/IIIa Receptor Antagonist by Batt, Douglas G, Houghton, Gregory C, Daneker, Wayne F, Jadhav, Prabhakar K

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Reduction of the active-site iron by potent inhibitors of lipoxygenases by Nelson, M.J, Batt, D.G, Thompson, J.S, Wright, S.W

“…Lipoxygenases are non-heme iron dioxygenases that catalyze the oxygenation of polyunsaturated fatty acids. Using soybean lipoxygenase-1 as a model, we have…”
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2'-Substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis by Batt, Douglas G, Goodman, Robin, Jones, David G, Kerr, Janet S, Mantegna, Lisa R, McAllister, Candice, Newton, Robert C, Nurnberg, Sherrill, Welch, Patricia K, Covington, Maryanne B

“…A series of 2'-substituted chalcone derivatives has been found to show potent inhibition of the production of IL-1 beta from human peripheral blood monocytes…”
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Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents by Batt, Douglas G., Petraitis, Joseph J., Sherk, Susan R., Copeland, Robert A., Dowling, Randine L., Taylor, Tracy L., Jones, Elizabeth A., Magolda, Ronald L., Jaffee, Bruce D.

“…Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring…”
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Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs by Pinto, Donald J.P., Batt, Douglas G., Pitts, William J., Petraitis, Joseph J., Orwat, Michael J., Wang, Shuaige, Jetter, James W., Sherk, Susan R., Houghton, Gregory C., Copeland, Robert A., Covington, Maryanne B., Trzaskos, James M., Magolda, Ronald L.

“…The discovery of terphenyl derivatives as highly selective COX-2 inhibitors resulted from our efforts to overcome poor pharmacokinetics demonstrated by the…”
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Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium by Pitts, William J, Jetter, James W, Pinto, Donald J, Orwat, Michael J, Batt, Douglas G, Sherk, Susan R, Petraitis, Joseph J, Jacobson, Irina C, Copeland, Robert A, Dowling, Randine L, Jaffee, Bruce D, Gardner, Tracy L, Jones, Elizabeth A, Magolda, Ronald L

“…The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate…”
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2-Substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity by Batt, Douglas G, Maynard, George D, Petraitis, Joseph J, Shaw, Joan E, Galbraith, William, Harris, Richard R

“…The synthesis, biological evaluation, and structure-activity relationships of a series of 1-naphthols bearing carbon substituents at the 2-position are…”
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Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3) by Batt, D G, Petraitis, J J, Houghton, G C, Modi, D P, Cain, G A, Corjay, M H, Mousa, S A, Bouchard, P J, Forsythe, M S, Harlow, P P, Barbera, F A, Spitz, S M, Wexler, R R, Jadhav, P K

“…A new series of indazole-containing alpha(v)beta(3) integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural…”
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Heteroaryl-Fused 2-Phenylisothiazolone Inhibitors of Cartilage Breakdown by Wright, Stephen W, Petraitis, Joseph J, Abelman, Matthew M, Batt, Douglas G, Bostrom, Lori L, Corbett, Ronald L, Decicco, Carl P, Di Meo, Susan V, Freimark, Bruce

“…The synthesis, biological evaluation, and structure-activity relationships of a series of N-phenyl heteroaryl-fused isothiazolones are described. These…”
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Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity by Wright, Stephen W, Harris, Richard R, Collins, Robert J, Corbett, Ronald L, Green, Alicia M, Wadman, Eric A, Batt, Douglas G

“…The synthesis, biological evaluation, and structure-activity relationships of a series of 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols are described. These…”
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Effects of the novel alphav integrin antagonist SM256 and cis-platinum on growth of murine squamous cell carcinoma PAM LY8 by Van Waes, C, Enamorado-Ayala, I, Hecht, D, Sulica, L, Chen, Z, Batt, D G, Mousa, S

“…Increased density of proliferating and migrating tumor cells and neovascular endothelial cells has been associated with tumor progression and poor prognosis in…”
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5-lipoxygenase inhibitors and their anti-inflammatory activities by Batt, D G

“…A wide variety of agents have been reported as 5-LO inhibitors. The majority of the series appear to be lipophilic reducing agents, including phenols,…”
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Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists by Xue, Chu-Biao, Wityak, John, Sielecki, Thais M, Pinto, Donald J, Batt, Douglas G, Cain, Gary A, Sworin, Michael, Rockwell, Arlene L, Roderick, John J, Wang, Shuaige, Orwat, Michael J, Frietze, William E, Bostrom, Lori L, Liu, Jie, Higley, C. Anne, Rankin, F. Wayne, Tobin, A. Ewa, Emmett, George, Lalka, George K, Sze, Jean Y, Di Meo, Susan V, Mousa, Shaker A, Thoolen, Martin J, Racanelli, Adrienne L, Hausner, Elizabeth A, Reilly, Thomas M, DeGrado, William F, Wexler, Ruth R, Olson, Richard E

“…Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic…”
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Orally Active Isoxazoline Glycoprotein IIb/IIIa Antagonists with Extended Duration of Action by Olson, Richard E, Sielecki, Thais M, Wityak, John, Pinto, Donald J, Batt, Douglas G, Frietze, William E, Liu, Jie, Tobin, A. Ewa, Orwat, Michael J, Di Meo, Susan V, Houghton, Gregory C, Lalka, George K, Mousa, Shaker A, Racanelli, Adrienne L, Hausner, Elizabeth A, Kapil, Ram P, Rabel, Shelley R, Thoolen, Martin J, Reilly, Thomas M, Anderson, Paul S, Wexler, Ruth R

“…Modification of the α-carbamate substituent of isoxazoline GPIIb/IIIa (αIIbβ3) antagonist DMP 754 (7) led to a series of α-sulfonamide and α-sulfamide…”
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Topical anti-inflammatory activity of DuP 654, a 2-substituted 1-naphthol by Harris, R R, Batt, D G, Galbraith, W, Ackerman, N R

“…Recent work suggests that one of the common biochemical characteristics of skin inflammatory diseases such as psoriasis is altered arachidonic acid metabolism…”
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An evaluation of 2-benzyl-1-naphthol (DuP 654) analogs as systemic anti-inflammatory agents by Kerr, J S, Batt, D G, Pinto, D J, Stampfli, H F

“…DuP 654 (2-benzyl-1-naphthol) is a topically active anti-inflammatory agent that was evaluated in phase II clinical trials as an anti-psoriatic agent. The…”
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Regioselectivity in the acid-catalyzed isomerization of 2-substituted 1,4-dihydro-1,4-epoxynaphthalenes by Batt, Douglas G, Jones, David G, La Greca, Susan

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Metabolism resistant isothiazolone inhibitors of cartilage breakdown by Wright, Stephen W., Petraitis, Joseph J., Batt, Douglas G., Corbett, Ronald L., Di Meo, Susan V., Freimark, Bruce, Giannaras, John V., Orwat, Michael J., Pinto, Donald J., Pratta, Michael A., Sherk, Susan R., Stampfli, Herman F., Williams, Jean M., Magolda, Ronald L., Arner, Elizabeth C.

“…A series of 2-(arylmethyl)pyridoisothiazolones is reported that inhibit the IL-1 β induced breakdown of bovine nasal septum cartilage in an organ culture…”
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General synthesis of pentacyclic quassinoids by Batt, Douglas G, Takamura, Norio, Ganem, Bruce

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