Search Results - "Batra, V K"

A review of recent experiments on step-to-step “hand-off” of the DNA intermediates in mammalian base excision repair pathways by Prasad, R., Beard, W. A., Batra, V. K., Liu, Y., Shock, D. D., Wilson, S. H.

“…The current “working model” for mammalian base excision repair involves two sub-pathways termed single-nucleotide base excision repair and long patch base…”
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A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma by Obiefuna, P C M, Batra, V K, Nadeem, A, Borron, P, Wilson, C N, Mustafa, S Jamal

“…Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Adenosine produces bronchoconstriction in allergic rabbits,…”
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Disposition and pharmacokinetics of temozolomide in rat by Reyderman, L., Statkevich, P., Thonoor, C. M., Patrick, J., Batra, V. K., Wirth, M.

“…1. Temozolomide, an imidazotetrazine derivative, is a cytotoxic alkylating agent of broad-spectrum antitumour activity. The absorption, metabolism,…”
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Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine by Kosoglou, T., Salfi, M., Lim, J. M., Batra, V. K., Cayen, M. N., Affrime, M. B.

“…Aims  To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the…”
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Population pharmacokinetics of temozolomide in cancer patients by JEN, J. Frank, CUTLER, David L, PAI, Sudhakar M, BATRA, Vijay K, AFFRIME, Melton B, ZAMBAS, Demetris N, HEFT, Samuel, HAJIAN, Gerald

“…To evaluate covariate effects on the pharmacokinetics of temozolomide in cancer patients, and to explore the dose-pharmacokinetics-toxicity relationship of…”
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ETB receptors on aortic smooth muscle cells of spontaneously hypertensive rats by Batra, V K, McNeill, J R, Xu, Y, Wilson, T W, Gopalakrishnan, V

“…The effect of the agonist sarafotoxin 6c (S6c), selective for endothelin (ET) receptor subtype B (ETB), on cytosolic free Ca2+ concentrations ([Ca2+]i) was…”
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Toxicokinetics/toxicodynamic correlations: goals, methods, and limitations by Batra, V K

“…Toxicokinetic (TK) studies are the basis for demonstrating dose-related drug exposure in animals and for ensuring that drug exposure is substantially greater…”
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Performance of Bailer's method for AUC confidence intervals from sparse non-normally distributed drug concentrations in toxicokinetic studies by PAI, S. M, NEDELMAN, J. R, HAJIAN, G, GIBIANSKY, E, BATRA, V. K

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Pneumadin-evoked intracellular free Ca2+ responses in rat aortic smooth muscle cells : Effect of dexamethasone by BATRA, V. K, HOPFNER, R. L, GOPALAKRISHNAN, V, MCNEILL, J. R

“…The direct vascular effect of pneumadin (PN) was determined by studying the changes in intracellular free calcium ([Ca2+]i) levels in cultured rat aortic…”
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Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism by Prasad, Rajendra, Batra, Vinod K., Yang, Xiao-Ping, Krahn, Joseph M., Pedersen, Lars C., Beard, William A., Wilson, Samuel H.

“…A large number of biochemical and genetic studies have demonstrated the involvement of DNA polymerase β (Pol β) in mammalian base excision repair (BER). Pol β…”
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A population pharmacokinetic model that describes multiple peaks due to enterohepatic recirculation of ezetimibe by Ezzet, Farkad, Krishna, Gopal, Wexler, David B., Statkevich, Paul, Kosoglou, Teddy, Batra, Vijay K.

“…Background: Ezetimibe, a selective inhibitor of intestinal cholesterol absorption, is in clinical development for the treatment of hypercholesterolemia. It is…”
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Characterization of AUCs from sparsely sampled populations in toxicology studies by PAI, S. M, FETTNER, S. H, HAJIAN, G, CAYEN, M. N, BATRA, V. K

“…The objective of this work was to develop and validate blood sampling schemes for accurate AUC determination from a few samples (sparse sampling). This will…”
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P2X purinoceptors in the feline pulmonary vascular bed: distribution and selective in vivo pharmacological probes by Neely, C F, Matot, I, Batra, V K, Bo, X, Burnstock, G

“…The distribution and identification of selective pharmacological probes for P2X purinoceptors in the pulmonary vascular (PV) bed of the cat have been…”
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Pharmacokinetics of loratadine and pseudoephedrine following single and multiple doses of once- versus twice-daily combination tablet formulations in healthy adult males by Kosoglou, Teddy, Radwanski, Elaine, Batra, Vijay K., Lim, Josephine M., Christopher, David, Affrime, Melton B.

“…The pharmacokinetic profiles of single and multiple doses of loratadine, descarboethoxyloratadine (DCL) (the major active metabolite of loratadine), and…”
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Disposition of cefixime in the pregnant and lactating rat. Transfer to the fetus and nursing pup by Halperin-Walega, E, Batra, V K, Tonelli, A P, Barr, A, Yacobi, A

“…The disposition of cefixime, a potent, third generation, orally active cephalosporin, was characterized in the pregnant and lactating rat. After a single iv…”
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In vitro microtuberization in potato (Solanum tuberosum L.) cultivars by Sakha, B M, Bhatia, A K, Batra, V K, Chaudhary, V K, Batra, P, Khurana, S C

“…Mechanism of microtuberization in three elite cultivars kufri badhsha (KB), kufri chandramukhi (KCM) and kufri jawahar (KJ) of potato was studied. Sprouts of…”
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Pneumadin: a new lung peptide which triggers antidiuresis by Batra, V K, Mathur, M, Mir, S A, Kapoor, R, Kumar, M A

“…Normal mammalian lungs, including human fetal lungs, contain significant amounts of a decapeptide which releases arginine-vasopressin from the neurophypophysis…”
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Capillary gas chromatographic-mass spectrometric analysis of 15-deoxy-16-hydroxy-16-vinylprostaglandin E2 by Cosulich, D B, Perkinson, N A, Batra, V K

“…A new topically active antihypertensive agent, the methyl ester of 15-deoxy-16-hydroxy-16-vinylprostaglandin E2 (1), rapidly hydrolyzes in blood to the…”
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Growth of Nb3Sn in multifilamentary bronze composites by AGARWAL, S. K, SAMANTA, S. B, BATRA, V. K, NARLIKAR, A. V

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Pharmacokinetics of mitoxantrone in man and laboratory animals by Batra, V K, Morrison, J A, Woodward, D L, Siverd, N S, Yacobi, A

“…Mitoxantrone (NOVANTRONE), an anthracenedione, is a novel anticancer agent with a wide spectrum of antitumor activity. Its anticancer activity is comparable to…”
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