Search Results - "Batkai, Sandor"

Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction by Piccoli, Maria-Teresa, Gupta, Shashi Kumar, Viereck, Janika, Foinquinos, Ariana, Samolovac, Sabine, Kramer, Freya Luise, Garg, Ankita, Remke, Janet, Zimmer, Karina, Batkai, Sandor, Thum, Thomas

“…Cardiac fibroblasts (CFs) drive extracellular matrix remodeling after pressure overload, leading to fibrosis and diastolic dysfunction. Recent studies…”
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Preclinical development of a miR-132 inhibitor for heart failure treatment by Foinquinos, Ariana, Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Gyöngyösi, Mariann, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Weber, Natalie, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Fiedler, Jan, Dangwal, Seema, Fischer, Martin, de la Roche, Jeanne, Wojciechowski, Daniel, Kraft, Theresia, Garamvölgyi, Rita, Neitzel, Sonja, Chatterjee, Shambhabi, Yin, Xiaoke, Bär, Christian, Mayr, Manuel, Xiao, Ke, Thum, Thomas

“…Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing…”
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Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity by Tam, Joseph, Vemuri, V Kiran, Liu, Jie, Bátkai, Sándor, Mukhopadhyay, Bani, Godlewski, Grzegorz, Osei-Hyiaman, Douglas, Ohnuma, Shinobu, Ambudkar, Suresh V, Pickel, James, Makriyannis, Alexandros, Kunos, George

“…Obesity and its metabolic consequences are a major public health concern worldwide. Obesity is associated with overactivity of the endocannabinoid system,…”
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Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction by Gupta, Shashi Kumar, PhD, Foinquinos, Ariana, MSc, Thum, Sabrina, Remke, Janet, Zimmer, Karina, Bauters, Christophe, MD, de Groote, Pascal, MD, Boon, Reinier A., PhD, de Windt, Leon J., PhD, Preissl, Sebastian, PhD, Hein, Lutz, MD, Batkai, Sandor, MD, PhD, Pinet, Florence, PhD, Thum, Thomas, MD, PhD

“…Abstract Background Aging populations show higher incidences of myocardial infarction (MI) and heart failure (HF). Cardiac remodeling post-MI leads to…”
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Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice by Osei-Hyiaman, Douglas, Liu, Jie, Zhou, Liang, Godlewski, Grzegorz, Harvey-White, Judith, Jeong, Won-il, Bátkai, Sándor, Marsicano, Giovanni, Lutz, Beat, Buettner, Christoph, Kunos, George

“…Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been…”
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Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro by Mukhopadhyay, Partha, Rajesh, Mohanraj, Bátkai, Sándor, Kashiwaya, Yoshihiro, Haskó, György, Liaudet, Lucas, Szabó, Csaba, Pacher, Pál

“…Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited because of its cardiotoxicity. Cell death is a key component in…”
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Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death by Mukhopadhyay, Partha, Rajesh, Mohanraj, Horváth, Béla, Bátkai, Sándor, Park, Ogyi, Tanchian, Galin, Gao, Rachel Y., Patel, Vivek, Wink, David A., Liaudet, Lucas, Haskó, György, Mechoulam, Raphael, Pacher, Pál

“…Ischemia/reperfusion (I/R) is a pivotal mechanism of liver damage after liver transplantation or hepatic surgery. We have investigated the effects of…”
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Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy by Mukhopadhyay, Partha, Rajesh, Mohanraj, Pan, Hao, Patel, Vivek, Mukhopadhyay, Bani, Bátkai, Sándor, Gao, Bin, Haskó, György, Pacher, Pál

“…Cisplatin is an important chemotherapeutic agent; however, its nephrotoxicity limits its clinical use. Enhanced inflammatory response and oxidative/nitrosative…”
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The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy by Ucar, Ahmet, Gupta, Shashi K., Fiedler, Jan, Erikci, Erdem, Kardasinski, Michal, Batkai, Sandor, Dangwal, Seema, Kumarswamy, Regalla, Bang, Claudia, Holzmann, Angelika, Remke, Janet, Caprio, Massimiliano, Jentzsch, Claudia, Engelhardt, Stefan, Geisendorf, Sabine, Glas, Carolina, Hofmann, Thomas G., Nessling, Michelle, Richter, Karsten, Schiffer, Mario, Carrier, Lucie, Napp, L. Christian, Bauersachs, Johann, Chowdhury, Kamal, Thum, Thomas

“…Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development of heart failure, one of the leading medical causes of mortality…”
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CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model by Mukhopadhyay, Partha, Pan, Hao, Rajesh, Mohanraj, Bátkai, Sándor, Patel, Vivek, Harvey‐White, Judith, Mukhopadhyay, Bani, Haskó, György, Gao, Bin, Mackie, Ken, Pacher, Pál

“…Background and purpose:  Accumulating recent evidence suggests that cannabinoid‐1 (CB1) receptor activation may promote inflammation and cell death and its…”
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Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver by Jeong, Won-il, Osei-Hyiaman, Douglas, Park, Ogyi, Liu, Jie, Bátkai, Sándor, Mukhopadhyay, Partha, Horiguchi, Norio, Harvey-White, Judith, Marsicano, Giovanni, Lutz, Beat, Gao, Bin, Kunos, George

“…Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism…”
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AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction by Hinkel, Rabea, Batkai, Sandor, Bähr, Andrea, Bozoglu, Tarik, Straub, Sarah, Borchert, Tobias, Viereck, Janika, Howe, Andrea, Hornaschewitz, Nadja, Oberberger, Lisa, Jurisch, Victoria, Kozlik-Feldmann, Rainer, Freudenthal, Franz, Ziegler, Tilman, Weber, Christian, Sperandio, Markus, Engelhardt, Stefan, Laugwitz, Karl Ludwig, Moretti, Alessandra, Klymiuk, Nik, Thum, Thomas, Kupatt, Christian

“…Pathological cardiac hypertrophy is a result of afterload-increasing pathologies including untreated hypertension and aortic stenosis. It features progressive…”
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A new cannabinoid CB2 receptor agonist HU‐910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury by Horváth, Bėla, Magid, Lital, Mukhopadhyay, Partha, Bátkai, Sándor, Rajesh, Mohanraj, Park, Ogyi, Tanchian, Galin, Gao, Rachel Y, Goodfellow, Catherine E, Glass, Michelle, Mechoulam, Raphael, Pacher, Pál

“…BACKGROUND AND PURPOSE Cannabinoid CB2 receptor activation has been reported to attenuate myocardial, cerebral and hepatic ischaemia‐reperfusion (I/R) injury…”
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Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis by Lorenzen, Johan M, Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K, Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A, Weidemann, Frank, Müller, Oliver J, Haller, Hermann, Thum, Thomas

“…Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are…”
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Novel insight into arrhythmogenic remodeling: a target for reversal by Batkai, Sandor, Foinquinos, Ariana

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Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption by Rajesh, Mohanraj, Mukhopadhyay, Partha, Bátkai, Sándor, Haskó, György, Liaudet, Lucas, Drel, Viktor R, Obrosova, Irina G, Pacher, Pál

“…A nonpsychoactive cannabinoid cannabidiol (CBD) has been shown to exert potent anti-inflammatory and antioxidant effects and has recently been reported to…”
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Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury by Bátkai, Sándor, Osei-Hyiaman, Douglas, Pan, Hao, El-Assal, Osama, Rajesh, Mohanraj, Mukhopadhyay, Partha, Hong, Feng, Harvey-White, Judith, Jafri, Anjum, Haskó, György, Huffman, John W, Gao, Bin, Kunos, George, Pacher, Pál

“…Hepatic ischemia-reperfusion (I/R) injury continues to be a fatal complication that can follow liver surgery or transplantation. We have investigated the…”
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Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants by Mukhopadhyay, Partha, Horváth, Bėla, Zsengellėr, Zsuzsanna, Bátkai, Sándor, Cao, Zongxian, Kechrid, Malek, Holovac, Eileen, Erdėlyi, Katalin, Tanchian, Galin, Liaudet, Lucas, Stillman, Isaac E., Joseph, Joy, Kalyanaraman, Balaraman, Pacher, Pál

“…Mitochondrial reactive oxygen species generation has been implicated in the pathophysiology of ischemia–reperfusion (I/R) injury; however, its exact role and…”
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CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion by Rajesh, Mohanraj, Mukhopadhyay, Partha, Bátkai, Sándor, Haskó, György, Liaudet, Lucas, Huffman, John W, Csiszar, Anna, Ungvari, Zoltan, Mackie, Ken, Chatterjee, Subroto, Pacher, Pál

“…Targeting cannabinoid-2 (CB(2)) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms…”
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Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension by Gyöngyösi, Mariann, Pavo, Noemi, Lukovic, Dominika, Zlabinger, Katrin, Spannbauer, Andreas, Traxler, Denise, Goliasch, Georg, Mandic, Ljubica, Bergler-Klein, Jutta, Gugerell, Alfred, Jakab, Andras, Szankai, Zsuzsanna, Toth, Levente, Garamvölgyi, Rita, Maurer, Gerald, Jaisser, Frederic, Zannad, Faiez, Thum, Thomas, Bátkai, Sándor, Winkler, Johannes

“…Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic…”
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