Prevalence of proton pump inhibitors drug interactions in community pharmacy: a network analysis approach
Objective: The aim of this study is to identify the prevalence of drug interaction associated with proton pump inhibitors, associated factors and drugs involved. Methods: Cross-sectional study in 194 customers (> 18 years) of community pharmacies shortly after proton pump inhibitors acquisition (...
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| Published in: | Jornal de Assistência Farmacêutica e Farmacoeconomia Vol. 8; no. 2 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Instituto Nacional de Assistência Farmacêutica e Farmacoeconomia
17-07-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective: The aim of this study is to identify the prevalence of drug interaction associated with proton pump inhibitors, associated factors and drugs involved. Methods: Cross-sectional study in 194 customers (> 18 years) of community pharmacies shortly after proton pump inhibitors acquisition (March 2019 to March 2020). Risk factors for drug interaction were assessed via multivariate logistic regression and relevance by network analysis. Results: The prevalence of drug interaction was 16.4% and was related to older age (OR=1.05; 95%CI 1.03 - 1.07) and female sex (OR=2.27; 95%CI 1, 15 - 4.47). The network analysis identified drug interaction involving omeprazole and pantoprazole as the most relevant and related to the prescription of levothyroxine, clopidogrel and cilostazol. Conclusion: The drug interaction among proton pump inhibitors users increase with age and are more common in women, especially those associated with levothyroxine, cilostazol and clopidogrel. |
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| ISSN: | 2525-5010 2525-7323 |
| DOI: | 10.22563/2525-7323.2023.v8.n.2.p.15-22 |