Isoflavones-functionalized single-walled and multi-walled carbon nanotubes: Synthesis and characterization of new nanoarchitetonics for biomedical uses

•Single-walled and multiple-walled CNTs were functionalized with two selected isoflavones.•Selected isoflavones (biochanin A and formononetin) are found in Brazilian red propolis.•Biochanin A and formononetin have antiproliferative activities.•Acidic treatment of SWCNTs and MWCNTs improved their dis...

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Bibliographic Details
Published in:	Journal of molecular structure Vol. 1294; p. 136351
Main Authors:	Novais, Gabrielle B., Dias, Mariana A., Santana, Adilson A.M., Batista, Thigna C., Marques, Maria N., Melo, Carlisson R., Albuquerque, Ricardo L.C., Gomes, Margarete Z., Severino, Patricia, Souto, Eliana B., Cardoso, Juliana C.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-12-2023
Subjects:	Biochanin A and formononetin Functionalization Multiple-walled carbon nanotubes Single-walled carbon nanotubes Functionalization Multiple-walled carbon nanotubes Biochanin A and formononetin Single-walled carbon nanotubes
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Summary:	•Single-walled and multiple-walled CNTs were functionalized with two selected isoflavones.•Selected isoflavones (biochanin A and formononetin) are found in Brazilian red propolis.•Biochanin A and formononetin have antiproliferative activities.•Acidic treatment of SWCNTs and MWCNTs improved their dispersibility in water.•SWCNTAs lost thermal stability after functionalization and showed lower loading capacity for isoflavones. In this work, we describe the functionalization of single-walled carbon nanotubes (SWCNTs) and multiple-walled carbon nanotubes (MWCNTs) with two selected isoflavones (biochanin A and formononetin), and compare the physicochemical properties of the obtained assemblies. The selection of isoflavones was based on the preliminary assessment of bibliometric maps generated from Scopus core collection. Acidic treatment of SWCNTs and MWCNTs improved the samples’ dispersibility in water. Regardless the pH environment, SWCNTs remained aggregated in aqueous solution, even after functionalization. The dispersibility of MWCNT increased after acidic treatment (MWCNTA) in both tested pH values (4 and 7). Functionalization was confirmed by the improved dispersibility of CNTs with both isoflavones. MWNCTA and isoflavone 1:1 (w/w) was used for both molecules. Biochanin A showed improved anchoring in MWNCTA when compared to formononetin. Our results corroborate the interest on the use of these new biomaterials based on carbon nanotubes for a range of biomedical applications.
ISSN:	0022-2860 1872-8014
DOI:	10.1016/j.molstruc.2023.136351