Search Results - "Batista, Thiago M."

Defining the underlying defect in insulin action in type 2 diabetes by Batista, Thiago M., Haider, Nida, Kahn, C. Ronald

“…Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over the past 50 years, elucidation of the insulin signalling network…”
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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins by Softic, Samir, Meyer, Jesse G, Wang, Guo-Xiao, Gupta, Manoj K, Batista, Thiago M, Lauritzen, Hans P M M, Fujisaka, Shiho, Serra, Dolors, Herrero, Laura, Willoughby, Jennifer, Fitzgerald, Kevin, Ilkayeva, Olga, Newgard, Christopher B, Gibson, Bradford W, Schilling, Birgit, Cohen, David E, Kahn, C Ronald

“…Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin…”
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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes by Batista, Thiago M., Jayavelu, Ashok Kumar, Wewer Albrechtsen, Nicolai J., Iovino, Salvatore, Lebastchi, Jasmin, Pan, Hui, Dreyfuss, Jonathan M., Krook, Anna, Zierath, Juleen R., Mann, Matthias, Kahn, C. Ronald

“…Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding and predicting disease development. To what extent this reflects…”
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Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis by Nagao, Hirofumi, Jayavelu, Ashok Kumar, Cai, Weikang, Pan, Hui, Dreyfuss, Jonathan M., Batista, Thiago M., Brandão, Bruna B., Mann, Matthias, Kahn, C. Ronald

“…Insulin acts through the insulin receptor (IR) tyrosine kinase to exert its classical metabolic and mitogenic actions. Here, using receptors with either short…”
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Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens by Cai, Weikang, Zhang, Xuemei, Batista, Thiago M, García-Martín, Rubén, Softic, Samir, Wang, Guoxiao, Ramirez, Alfred K, Konishi, Masahiro, O'Neill, Brian T, Kim, Jong Hun, Kim, Jason K, Kahn, C Ronald

“…The brain is now recognized as an insulin-sensitive tissue; however, the role of changing insulin concentrations in the peripheral circulation in gene…”
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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo by Batista, Thiago M., Garcia-Martin, Ruben, Cai, Weikang, Konishi, Masahiro, O’Neill, Brian T., Sakaguchi, Masaji, Kim, Jong Hun, Jung, Dae Young, Kim, Jason K., Kahn, C. Ronald

“…Regulation of gene expression is an important aspect of insulin action but in vivo is intertwined with changing levels of glucose and counter-regulatory…”
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Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice by Batista, Thiago M, Alonso-Magdalena, Paloma, Vieira, Elaine, Amaral, Maria Esmeria C, Cederroth, Christopher R, Nef, Serge, Quesada, Ivan, Carneiro, Everardo M, Nadal, Angel

“…Bisphenol-A (BPA) is one of the most widespread endocrine disrupting chemicals (EDC) used as the base compound in the manufacture of polycarbonate plastics…”
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Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance by Wang, Guoxiao, Yu, Yingying, Cai, Weikang, Batista, Thiago M, Suk, Sujin, Noh, Hye Lim, Hirshman, Michael, Nigro, Pasquale, Li, Mengyao Ella, Softic, Samir, Goodyear, Laurie, Kim, Jason K, Kahn, C Ronald

“…Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2 diabetes. In attempt to overcome this defect, we generated mice…”
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Taurine supplementation reduces blood pressure and prevents endothelial dysfunction and oxidative stress in post-weaning protein-restricted rats by Maia, Aline R, Batista, Thiago M, Victorio, Jamaira A, Clerici, Stefano P, Delbin, Maria A, Carneiro, Everardo M, Davel, Ana P

“…Taurine is a sulfur-containing amino acid that exerts protective effects on vascular function and structure in several models of cardiovascular diseases…”
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Taurine supplementation improves liver glucose control in normal protein and malnourished mice fed a high-fat diet by Batista, Thiago M., Ribeiro, Rosane A., da Silva, Priscilla M. R., Camargo, Rafael L., Lollo, Pablo C. B., Boschero, Antonio C., Carneiro, Everardo M.

“…Scope Poor nutrition during the perinatal period is associated with an increased risk for metabolic syndrome in adulthood. Taurine (TAU) regulates β‐cell…”
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Inhibitory Effects of Leptin on Pancreatic α-Cell Function by TUDURI, Eva, MARROQUI, Laura, QUESADA, Ivan, SORIANO, Sergi, ROPERO, Ana B, BATISTA, Thiago M, PIQUER, Sandra, LOPEZ-BOADO, Miguel A, CARNEIRO, Everardo M, GOMIS, Ramón, NADAL, Angel

“…Inhibitory Effects of Leptin on Pancreatic α-Cell Function Eva Tudurí 1 , 2 , Laura Marroquí 1 , 2 , Sergi Soriano 1 , 2 , Ana B. Ropero 1 , 2 , Thiago M…”
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Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects by Guerra, Beatriz A., Brandão, Bruna B., Pinto, Silas S., Salgueiro, Willian G., De-Souza, Evandro A., Reis, Felipe C.G., Batista, Thiago M., Cavalcante-Silva, Vanessa, D'Almeida, Vânia, Castilho, Beatriz A., Carneiro, Everardo M., Antebi, Adam, Festuccia, William T., Mori, Marcelo A.

“…Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we…”
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From In-Person to the Online World: Insights Into Organizing Events in Bioinformatics by da Silva, Alessandra Lima, Abreu, Ana Paula de, Mariano, Diego, Caixeta, Felipe, Santos, Fenícia Brito, Lage, Fernanda Stussi D., Quintanilha-Peixoto, Gabriel, Hilário, Heron. O., Xavier, Joicymara. S., Queiroz, Lucio. R., de Toledo, Nayara Evelin, Tavares, Raphael, Kato, Rodrigo Bentes, dos Santos, Roselane Gonçalves, Soares, Stellamaris, Goes, Wanessa. M., Nogueira, Wylerson. G., Batista, Thiago. M., Ortega, José Miguel, De Carvalho, Vasco Ariston Azevedo, Franco, Glória. Regina, Melo-Minardi, Raquel. C. de, Góes-Neto, Aristóteles

“…Bioinformatics is a fast-evolving research field, requiring effective educational initiatives to bring computational knowledge to Life Sciences. Since 2017, an…”
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Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway by Filiputti, Eliane, Rafacho, Alex, Araújo, Eliana P, Silveira, Leonardo R, Trevisan, Amon, Batista, Thiago M, Curi, Rui, Velloso, Lício A, Quesada, Ivan, Boschero, Antonio C, Carneiro, Everardo M

“…Abstract A regimen of low-protein diet induces a reduction of pancreatic islet function that is associated with development of metabolic disorders including…”
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223-OR: ADA Presidents' Select Abstract: Novel Ligand and Kinase-Independent Signaling by the Insulin Receptor by NAGAO, HIROFUMI, CAI, WEIKANG, PAN, HUI, BATISTA, THIAGO M., BRANDAO, BRUNA, KAHN, C. RONALD

“…Insulin acts through the insulin receptor (IR) tyrosine kinase and two major canonical post-receptor signaling pathways (the IRS-1/PI3K/Akt pathway and the…”
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Correction to: Defining the underlying defect in insulin action in type 2 diabetes by Batista, Thiago M., Haider, Nida, Kahn, C. Ronald

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Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains by Nagao, Hirofumi, Cai, Weikang, Albrechtsen, Nicolai J. Wewer, Steger, Martin, Batista, Thiago M., Pan, Hui, Dreyfuss, Jonathan M., Mann, Matthias, Kahn, C. Ronald

“…Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling pathways but have unique biological effects. To define the molecular…”
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Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex by Haider, Nida, Lebastchi, Jasmin, Jayavelu, Ashok Kumar, Batista, Thiago M, Pan, Hui, Dreyfuss, Jonathan M, Carcamo-Orive, Ivan, Knowles, Joshua W, Mann, Matthias, Kahn, C Ronald

“…Insulin resistance is present in one-quarter of the general population, predisposing these people to a wide range of diseases. Our aim was to identify…”
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35-OR: Physiological Insulin Regulates Alternative mRNA Splicing in Liver and Muscle at Multiple Levels by BATISTA, THIAGO M., CAI, WEIKANG, BRANDAO, BRUNA, KAHN, C. RONALD

“…Alternative splicing of mRNAs contributes importantly to proteome diversity and tissue identity. Work by us and others have suggested that alternative splicing…”
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1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome by NAGAO, HIROFUMI, CAI, WEIKANG, BATISTA, THIAGO M., PAN, HUI, DREYFUSS, JONATHAN, KAHN, C. RONALD

“…Insulin and IGF-1 regulate a wide variety of biological processes through insulin and IGF-1 receptors (IR and IGF1R). These receptors are highly homologous and…”
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