Comparative randomised trial of high and conventional doses of praziquantel in the treatment of schistosomiasis mansoni

Comparative randomised trial of high and conventional doses of praziquantel in the treatment of schistosomiasis mansoni

The efficacy of oral praziquantel in the treatment of schistosomiasis has been considered low by most public health institutions. In this paper, we compared the efficacy of two dosages of praziquantel (80 mg/kg vs. 50 mg/kg) in patients with chronic schistosomiasis mansoni. Two hundred eighty-eight...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz Vol. 105; no. 4; pp. 445 - 448
Main Authors: de Queiroz, Leonardo C, Drummond, Sandra C, de Matos, Maria Laura M, Paiva, Mariana B.S, Batista, Thaís S, Kansaon, Ahraby Z.M, Antunes, Carlos Maurício de F, Lambertucci, José Roberto
Format: Journal Article
Language:English
Published: Brazil Fundação Oswaldo Cruz, Fiocruz 01-07-2010
Instituto Oswaldo Cruz, Ministério da Saúde
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects:
Administration, Oral
Adult
adverse reactions
Chronic Disease
Dose-Response Relationship, Drug
Feces - parasitology
Female
Humans
Male
Parasite Egg Count
PARASITOLOGY
praziquantel
Praziquantel - administration & dosage
Praziquantel - adverse effects
schistosomiasis
schistosomiasis mansoni
Schistosomiasis mansoni - drug therapy
schistosomiasis mansoni - schistosomiasis - praziquantel - treatment - therapeutic efficacy - adverse reactions
Schistosomicides - administration & dosage
Schistosomicides - adverse effects
therapeutic efficacy
Time Factors
treatment
TROPICAL MEDICINE
praziquantel
treatment
schistosomiasis
adverse reactions
schistosomiasis mansoni
therapeutic efficacy
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Summary:The efficacy of oral praziquantel in the treatment of schistosomiasis has been considered low by most public health institutions. In this paper, we compared the efficacy of two dosages of praziquantel (80 mg/kg vs. 50 mg/kg) in patients with chronic schistosomiasis mansoni. Two hundred eighty-eight patients with schistosomiasis from a community in Brazil were randomly divided into two groups: 145 patients (Group 1) received 80 mg/kg body weight of oral praziquantel divided in two equal doses with 1 h interval and 143 patients (Group 2) received 50 mg/kg body weight of oral praziquantel. To keep the study masked, patients in Group 2 received placebo 1 h after the first dose. All patients were subjected to clinical and ultrasonographic examination. Cure assessment was performed by re- peating two stool examinations, by a quantitative method, at 30, 90 and 180 days after treatment. The morbidity of schistosomiasis was low, with a few cases of light periportal thickening and 16 cases of mild splenomegaly. The cure rates were 89.7% for Group 1 and 83.9% for Group 2. There was no difference in the efficacy of both therapeutic dosages of praziquantel assayed. The adverse reactions were more frequent with higher dosage.
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ISSN:1678-8060
0074-0276
1678-8060
0074-0276
DOI:10.1590/S0074-02762010000400015