Search Results - "Batista, Pedro J"

Long Noncoding RNAs: Cellular Address Codes in Development and Disease by Batista, Pedro J., Chang, Howard Y.

“…In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential…”
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The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline by Bailey, Alexis S, Batista, Pedro J, Gold, Rebecca S, Chen, Y Grace, de Rooij, Dirk G, Chang, Howard Y, Fuller, Margaret T

“…The switch from mitosis to meiosis is the key event marking onset of differentiation in the germline stem cell lineage. In , the translational repressor Bgcn…”
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Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline by Gu, Weifeng, Shirayama, Masaki, Conte, Darryl, Vasale, Jessica, Batista, Pedro J., Claycomb, Julie M., Moresco, James J., Youngman, Elaine M., Keys, Jennifer, Stoltz, Matthew J., Chen, Chun-Chieh G., Chaves, Daniel A., Duan, Shenghua, Kasschau, Kristin D., Fahlgren, Noah, Yates, John R., Mitani, Shohei, Carrington, James C., Mello, Craig C.

“…Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we…”
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The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation by Claycomb, Julie M., Batista, Pedro J., Pang, Ka Ming, Gu, Weifeng, Vasale, Jessica J., van Wolfswinkel, Josien C., Chaves, Daniel A., Shirayama, Masaki, Mitani, Shohei, Ketting, René F., Conte, Darryl, Mello, Craig C.

“…RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the…”
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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans by Conine, Colin C, Batista, Pedro J, Gu, Weifeng, Claycomb, Julie M, Chaves, Daniel A, Shirayama, Masaki, Mello, Craig C

“…Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that…”
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PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans by Batista, Pedro J., Ruby, J. Graham, Claycomb, Julie M., Chiang, Rosaria, Fahlgren, Noah, Kasschau, Kristin D., Chaves, Daniel A., Gu, Weifeng, Vasale, Jessica J., Duan, Shenghua, Conte, Darryl, Luo, Shujun, Schroth, Gary P., Carrington, James C., Bartel, David P., Mello, Craig C.

“…In metazoans, Piwi-related Argonaute proteins have been linked to germline maintenance, and to a class of germline-enriched small RNAs termed piRNAs. Here we…”
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Ten simple rules for acing virtual interviews by Chan, Dalen, Fitzsimmons, Christina M, Mandler, Mariana D, Batista, Pedro J

“…A professional social media account can help to establish a positive online presence even before the interview. Since many admission committees and potential…”
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PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications by Fang, Jingwen, Ma, Qing, Chu, Ci, Huang, Beibei, Li, Lingjie, Cai, Pengfei, Batista, Pedro J, Tolentino, Karen Erisse Martin, Xu, Jin, Li, Rui, Du, Pengcheng, Qu, Kun, Chang, Howard Y

“…We develop PIRCh-seq, a method which enables a comprehensive survey of chromatin-associated RNAs in a histone modification-specific manner. We identify…”
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It's complicated… m6A-dependent regulation of gene expression in cancer by Fitzsimmons, Christina M., Batista, Pedro J.

“…Cellular function relies on multiple pathways that are coordinated to ensure the proper execution of gene expression networks. Failure to coordinate the…”
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The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1 by Haddad Derafshi, Bahareh, Danko, Tamas, Chanda, Soham, Batista, Pedro J., Litzenburger, Ulrike, Lee, Qian Yi, Ng, Yi Han, Sebin, Anu, Chang, Howard Y., Südhof, Thomas C., Wernig, Marius

“…The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement,…”
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CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs by van Wolfswinkel, Josien C., Claycomb, Julie M., Batista, Pedro J., Mello, Craig C., Berezikov, Eugene, Ketting, René F.

“…We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1…”
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Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway by Vasale, Jessica J, Gu, Weifeng, Thivierge, Caroline, Batista, Pedro J, Claycomb, Julie M, Youngman, Elaine M, Duchaine, Thomas F, Mello, Craig C, Conte, Darryl Jr

“…Argonaute (AGO) proteins interact with distinct classes of small RNAs to direct multiple regulatory outcomes. In many organisms, including plants, fungi, and…”
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The RNA Modification N 6 -methyladenosine and Its Implications in Human Disease by Batista, Pedro J

“…Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control…”
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The RNA Modification N6-methyladenosine and Its Implications in Human Disease by Batista, Pedro J.

“…Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control…”
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Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma by Fitzsimmons, Christina M, Mandler, Mariana D, Lunger, Judith C, Chan, Dalen, Maligireddy, Siddhardha S, Schmiechen, Alexandra C, Gamage, Supuni Thalalla, Link, Courtney, Jenkins, Lisa M, Chan, King, Andresson, Thorkell, Crooks, Daniel R, Meier, Jordan L, Linehan, W Marston, Batista, Pedro J

“…Metabolic reprogramming is a hallmark of cancer that facilitates changes in many adaptive biological processes. Mutations in the tricarboxylic acid cycle…”
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Sensing Self and Foreign Circular RNAs by Intron Identity by Chen, Y. Grace, Kim, Myoungjoo V., Chen, Xingqi, Batista, Pedro J., Aoyama, Saeko, Wilusz, Jeremy E., Iwasaki, Akiko, Chang, Howard Y.

“…Circular RNAs (circRNAs) are single-stranded RNAs that are joined head to tail with largely unknown functions. Here we show that transfection of purified…”
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Small RNAs are modified with N-glycans and displayed on the surface of living cells by Flynn, Ryan A., Pedram, Kayvon, Malaker, Stacy A., Batista, Pedro J., Smith, Benjamin A.H., Johnson, Alex G., George, Benson M., Majzoub, Karim, Villalta, Peter W., Carette, Jan E., Bertozzi, Carolyn R.

“…Glycans modify lipids and proteins to mediate inter- and intramolecular interactions across all domains of life. RNA is not thought to be a major target of…”
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RNA: a double-edged sword in genome maintenance by Zong, Dali, Oberdoerffer, Philipp, Batista, Pedro J., Nussenzweig, André

“…All organisms must safeguard the integrity of their DNA to avoid deleterious consequences of genome instability, which have been linked to human diseases such…”
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Structure and Thermodynamics of N6‑Methyladenosine in RNA: A Spring-Loaded Base Modification by Roost, Caroline, Lynch, Stephen R, Batista, Pedro J, Qu, Kun, Chang, Howard Y, Kool, Eric T

“…N6-Methyladenosine (m6A) modification is hypothesized to control processes such as RNA degradation, localization, and splicing. However, the molecular…”
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RNA post-transcriptional modification speaks to chromatin by Chan, Dalen, Batista, Pedro J.

“…The role of N 6 -methyladenosine (m 6 A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m 6 A…”
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