Characterization of the mechanical and biological properties of a new alumina scaffold

In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute. In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold. The results obtained showed that this scaffold has high...

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Bibliographic Details
Published in:	Journal of applied biomaterials & functional materials Vol. 11; no. 1; p. e18
Main Authors:	Batista, Patrícia S P, Rodrigues, Miguel A A, Silva, Daniela M R, Morgado, Patrícia I C, Henriques, Joaquim P, Almeida, Maria O, Silva, Abílio P, Correia, Ilídio J
Format:	Journal Article
Language:	English
Published:	United States 01-01-2013
Subjects:	Aluminum Oxide - chemistry Aluminum Oxide - pharmacology Animals Bone Regeneration - drug effects Bone Substitutes - chemical synthesis Bone Substitutes - chemistry Bone Substitutes - pharmacology Cells, Cultured Humans Materials Testing Mechanical Phenomena Osteoblasts - drug effects Osteoblasts - physiology Rats Rats, Wistar Tissue Engineering - methods Tissue Scaffolds - chemistry
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Summary:	In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute. In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold. The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction. The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.
ISSN:	2280-8000
DOI:	10.5301/JABFM.2012.9264