Search Results - "Batista, M L"

Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells by Bispo, Daniela S C, Correia, Marlene, Carneiro, Tatiana J, Martins, Ana S, Reis, Aliana A N, Carvalho, Ana L M Batista de, Marques, Maria P M, Gil, Ana M

“…This work investigated the mechanisms of action of conventional drugs, cisplatin and oxaliplatin, and the potentially less deleterious drug Pd Spermine (Spm)…”
Get full text

Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy by Félix, Maria M, Tavares, Mariana V, Santos, Inês P, Batista de Carvalho, Ana L M, Batista de Carvalho, Luís A E, Marques, Maria Paula M

“…Cervical cancer was considered the fourth most common cancer worldwide in 2020. In order to reduce mortality, an early diagnosis of the tumor is required…”
Get full text

Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics by Carneiro, Tatiana J., Vojtek, Martin, Gonçalves-Monteiro, Salomé, Batista de Carvalho, Ana L. M., Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…Cisplatin (cDDP)-based chemotherapy is often limited by severe deleterious effects (nephrotoxicity, hepatotoxicity and neurotoxicity). The polynuclear…”
Get full text

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line by Silva, Jéssica D, Marques, Joana, Santos, Inês P, Batista de Carvalho, Ana L M, Martins, Clara B, Laginha, Raquel C, Batista de Carvalho, Luís A E, Marques, Maria Paula M

“…A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt Put (NH ) ]Cl ) was synthesized and assessed as to its potential anticancer…”
Get full text

Synchrotron nano-FTIR spectroscopy for probing anticancer drugs at subcellular scale by de Carvalho, Luis A. E. Batista, Cinque, Gianfelice, de Carvalho, Ana L. M. Batista, Marques, Joana, Frogley, Mark D., Vondracek, Hendrik, Marques, Maria Paula M.

“…The cellular response to cisplatin was assessed in human osteosarcoma cells, using synchrotron-based (SR) Fourier Transform InfraRed nanospectroscopy…”
Get full text

A New Look into the Mode of Action of Metal-Based Anticancer Drugs by Marques, M Paula M, Batista de Carvalho, Ana L M, Mamede, Adriana P, Dopplapudi, Asha, Rudić, Svemir, Tyagi, Madhusudan, Garcia Sakai, Victoria, Batista de Carvalho, Luís A E

“…The mode of action of Pt- and Pd-based anticancer agents (cisplatin and Pd Spm) was studied by characterising their impact on DNA. Changes in conformation and…”
Get full text

Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies by Laginha, Raquel C., Martins, Clara B., Brandão, Ana L. C., Marques, Joana, Marques, M. Paula M., Batista de Carvalho, Luís A. E., Santos, Inês P., Batista de Carvalho, Ana L. M.

“…Regarding the development of new antineoplastic agents, with a view to assess the selective antitumoral potential which aims at causing irreversible damage to…”
Get full text

Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model by Carneiro, Tatiana J., Araújo, Rita, Vojtek, Martin, Gonçalves-Monteiro, Salomé, de Carvalho, Ana L. M. Batista, Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…The interest in palladium(II) compounds as potential new anticancer drugs has increased in recent years, due to their high toxicity and acquired resistance to…”
Get full text

Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs by Martins, Ana S, Batista de Carvalho, Ana L M, Marques, Maria P M, Gil, Ana M

“…This paper reports the first metabolomics study of the impact of new chelates Pt Spm and Pd Spm (Spm = Spermine) on human osteosarcoma cellular metabolism,…”
Get full text

Cellular dynamics as a marker of normal-to-cancer transition in human cells by Marques, M. P. M., de Carvalho, A. L. M. Batista, Martins, C. B., Silva, J. D., Sarter, M., García Sakai, V., Stewart, J. R., de Carvalho, L. A. E. Batista

“…Normal-to-cancer (NTC) transition is known to be closely associated to cell´s biomechanical properties which are dependent on the dynamics of the intracellular…”
Get full text

Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia by Batista, M L, Neves, R X, Peres, S B, Yamashita, A S, Shida, C S, Farmer, S R, Seelaender, M

“…Cancer cachexia induces loss of fat mass that accounts for a large part of the dramatic weight loss observed both in humans and in animal models; however, the…”
Get full text

Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice by Carneiro, Tatiana J., Vojtek, Martin, Gonçalves-Monteiro, Salomé, Neves, João R., Carvalho, Ana L. M. Batista de, Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…The new palladium agent Pd2Spermine (Spm) has been reported to exhibit promising cytotoxic properties, while potentially circumventing the known disadvantages…”
Get full text

Concurrent training remodels the subcutaneous adipose tissue extracellular matrix of people living with HIV: a non-randomized clinical trial by Silva, B F, Barletta, F, Pedro, R E, Batista, Jr, M L, Hernandes, L, de Moraes, S M F, Peres, S B

“…Evaluate the effect of 12 wks of concurrent training (CT) in the extracellular matrix (ECM) of subcutaneous adipose tissue (SAT) in people living with HIV/AIDS…”
Get more information

Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics by Carneiro, Tatiana J, Carvalho, Ana L M Batista, Vojtek, Martin, Carmo, Inês F, Marques, Maria Paula M, Diniz, Carmen, Gil, Ana M

“…This work compared the metabolic profile of a parental MDA-MB-231 cisplatin-sensitive triple negative breast cancer (TNBC) cell line with that of a derived…”
Get full text

Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin by Vojtek, Martin, Martins, Clara B, Ramos, Raquel, Duarte, Sara Gomes, Ferreira, Isabel M P L V O, Batista de Carvalho, Ana L M, Marques, M Paula M, Diniz, Carmen

“…Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though…”
Get full text

Inflammation in Cachexia by Seelaender, M., Laviano, A., Busquets, S., Püschel, G. P., Margaria, T., Batista, M. L.

Get full text

Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity by Pires, Cristiana L., Praça, Catarina, Martins, Patrícia A. T., Batista de Carvalho, Ana L. M., Ferreira, Lino, Marques, Maria Paula M., Moreno, Maria João

“…Caco-2 monolayers are a common in vitro model used to evaluate human intestinal absorption. The reference protocol requires 21 days post-seeding to establish a…”
Get full text

Endurance training induces depot-specific changes in IL-10/TNF-α ratio in rat adipose tissue by Lira, F.S., Rosa, J.C., Yamashita, A.S., Koyama, C.H., Batista, M.L., Seelaender, M.

“…White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and recently, it has been recognized as an important source of interleukin 10…”
Get full text

Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63) by Dias, Lucas D, Batista de Carvalho, Ana L M, Pinto, Sara M A, Aquino, Gilberto L B, Calvete, Mário J F, Rossi, Liane M, Marques, M P M, Pereira, Mariette M

“…In the present study, we developed a green epoxidation approach for the synthesis of the diastereomers of (-)-isopulegol benzyl ether epoxide using molecular…”
Get full text

Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent by Carneiro, Tatiana J, Araújo, Rita, Vojtek, Martin, Gonçalves-Monteiro, Salomé, Diniz, Carmen, Batista de Carvalho, Ana L M, Marques, M Paula M, Gil, Ana M

“…Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to Pt(II)-based drugs (e.g., cisplatin), which typically trigger…”
Get full text