IFITM3 rs12252 polymorphism association with COVID-19 severity and mortality in a Brazilian sample: an update and a meta-analysis

IFITM3 rs12252 polymorphism association with COVID-19 severity and mortality in a Brazilian sample: an update and a meta-analysis

This study investigated the association between the IFITM3 rs12252 polymorphism and the severity and mortality of COVID-19 in hospitalized Brazilian patients. A total of 102 COVID-19 patients were included, and the outcomes of interest were defined as death and the need for mechanical ventilation. G...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências Vol. 96; no. 2; p. e20231160
Main Authors: Araújo, João L F DE, Bonifácio, Victória F, Batista, Lorena M, Ávila, Renata Eliane DE, Aguiar, Renato S, Bastos-Rodrigues, Luciana, Souza, Renan P DE
Format: Journal Article
Language:English
Published: Brazil Academia Brasileira de Ciências 01-01-2024
Subjects:
Adult
Aged
Betacoronavirus - genetics
Brazil - epidemiology
COVID-19 - genetics
COVID-19 - mortality
COVID-19 prognosis
Female
genetic association
Genetic Predisposition to Disease - genetics
Genotype
Humans
interferon
Male
Membrane Proteins - genetics
Middle Aged
MULTIDISCIPLINARY SCIENCES
Pandemics
Pneumonia, Viral - genetics
Pneumonia, Viral - mortality
Polymorphism, Single Nucleotide - genetics
polymorphisms
Respiration, Artificial
RNA-Binding Proteins - genetics
SARS-CoV-2 - genetics
Severity of Illness Index
SNP
Brazil
genetic association
SNP
interferon
COVID-19 prognosis
polymorphisms
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Summary:This study investigated the association between the IFITM3 rs12252 polymorphism and the severity and mortality of COVID-19 in hospitalized Brazilian patients. A total of 102 COVID-19 patients were included, and the outcomes of interest were defined as death and the need for mechanical ventilation. Genotypes were assessed using Taqman probes. No significant associations were found between the rs12252 polymorphism and COVID-19 outcomes in the original sample, both for death and the need for mechanical ventilation. A meta-analysis, incorporating previous studies that used death as a severity indicator, revealed no association in the allelic and C-recessive models. However, due to the rarity of the T allele and its absence in the sample, further replication studies in larger and more diverse populations are needed to clarify the role of rs12252 in COVID-19 prognosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202420231160