Search Results - "Batista, Fernanda A.H"

Identification of two p23 co‐chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities by Batista, Fernanda A.H, Almeida, Glessler S, Seraphim, Thiago V, Silva, Kelly P, Murta, Silvane M.F, Barbosa, Leandro R.S, Borges, Júlio C

“…The small acidic protein called p23 acts as a co‐chaperone for heat‐shock protein of 90 kDa (Hsp90) during its ATPase cycle. p23 proteins inhibit Hsp90 ATPase…”
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From Conformation to Interaction: Techniques to Explore the Hsp70/Hsp90 Network by Batista, Fernanda A H, Gava, Lisandra M, Pinheiro, Glaucia M S, Ramos, Carlos H I, Borges, Julio C

“…Proteins participate in almost every cell physiological function, and to do so, they need to reach a state that allows its function by folding and/or exposing…”
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PtII, PdII and AuIII complexes with a thiosemicarbazone derived from diacethylmonooxime: Structural analysis, trypanocidal activity, cytotoxicity and first insight into the antiparasitic mechanism of action by Gonçalves, Ana C.R., Carneiro, Zumira A., Oliveira, Carolina G., Danuello, Amanda, Guerra, Wendell, Oliveira, Ronaldo J., Ferreira, Francis B., Veloso-Silva, Laudimir L.W., Batista, Fernanda A.H., Borges, Júlio C., de Albuquerque, Sérgio, Deflon, Victor M., Maia, Pedro I.S.

“…New complexes of composition [MX(HL1)] (M = PtII, PdII, X = Cl− or I−) and [MX(L1)] (M = AuIII, X = Cl−; M = PtII, PdII, X = PPh3) have been synthesized using…”
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Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target by Moraes, Beatriz C, Ribeiro-Filho, Helder V, Roldão, Allan P, Toniolo, Elaine F, Carretero, Gustavo P B, Sgro, Germán G, Batista, Fernanda A H, Berardi, Damian E, Oliveira, Victoria R S, Tomasin, Rebeka, Vieceli, Felipe M, Pramio, Dimitrius T, Cardoso, Alexandre B, Figueira, Ana C M, Farah, Shaker C, Devi, Lakshmi A, Dale, Camila S, de Oliveira, Paulo S L, Schechtman, Deborah

“…Chronic pain is a major health issue, and the search for new analgesics has become increasingly important because of the addictive properties and unwanted side…”
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Structural and functional studies of the Leishmania braziliensis SGT co-chaperone indicate that it shares structural features with HIP and can interact with both Hsp90 and Hsp70 with similar affinities by Coto, Amanda L.S., Seraphim, Thiago V., Batista, Fernanda A.H., Dores-Silva, Paulo R., Barranco, Ana Beatriz F., Teixeira, Felipe R., Gava, Lisandra M., Borges, Júlio C.

“…Molecular chaperones and co-chaperones play an essential role in the life cycles of protozoa belonging to the genus Leishmania. The small glutamine-rich…”
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Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone by Batista, Fernanda A. H., Ramos, Sérgio L., Tassone, Giusy, Leitão, Andrei, Montanari, Carlos A., Botta, Maurizio, Mori, Mattia, Borges, Júlio C.

“…Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are…”
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Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding by Batista, Fernanda A H, Trivella, Daniela B B, Bernardes, Amanda, Gratieri, Joyce, Oliveira, Paulo S L, Figueira, Ana Carolina M, Webb, Paul, Polikarpov, Igor

“…Peroxisome proliferator activated receptors (PPARs δ, α and γ) are closely related transcription factors that exert distinct effects on fatty acid and glucose…”
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Pt II , Pd II and Au III complexes with a thiosemicarbazone derived from diacethylmonooxime: Structural analysis, trypanocidal activity, cytotoxicity and first insight into the antiparasitic mechanism of action by Gonçalves, Ana C R, Carneiro, Zumira A, Oliveira, Carolina G, Danuello, Amanda, Guerra, Wendell, Oliveira, Ronaldo J, Ferreira, Francis B, Veloso-Silva, Laudimir L W, Batista, Fernanda A H, Borges, Júlio C, de Albuquerque, Sérgio, Deflon, Victor M, Maia, Pedro I S

“…New complexes of composition [MX(HL1)] (M = Pt , Pd , X = Cl or I ) and [MX(L1)] (M = Au , X = Cl ; M = Pt , Pd , X = PPh ) have been synthesized using a…”
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Low sequence identity but high structural and functional conservation: The case of Hsp70/Hsp90 organizing protein (Hop/Sti1) of Leishmania braziliensis by Batista, Fernanda A.H., Seraphim, Thiago V., Santos, Clelton A., Gonzaga, Marisvanda R., Barbosa, Leandro R.S., Ramos, Carlos H.I., Borges, Júlio C.

“…Parasites belonging to the genus Leishmania are subjected to extensive environmental changes during their life cycle; molecular chaperones/co-chaperones act as…”
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Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution by Bernardes, Amanda, Batista, Fernanda A H, de Oliveira Neto, Mario, Figueira, Ana Carolina M, Webb, Paul, Saidemberg, Daniel, Palma, Mario S, Polikarpov, Igor

“…The peroxisome proliferator-activated receptors (PPARs) regulate genes involved in lipid and carbohydrate metabolism, and are targets of drugs approved for…”
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Protein Disulfide Isomerase Modulates the Activation of Thyroid Hormone Receptors by Campos, Jessica L O, Doratioto, Tabata R, Videira, Natalia B, Ribeiro Filho, Helder V, Batista, Fernanda A H, Fattori, Juliana, Indolfo, Nathalia de C, Nakahira, Marcel, Bajgelman, Marcio C, Cvoro, Aleksandra, Laurindo, Francisco R M, Webb, Paul, Figueira, Ana Carolina M

“…Thyroid hormone receptors (TRs) are responsible for mediating thyroid hormone (T3 and T4) actions at a cellular level. They belong to the nuclear receptor (NR)…”
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High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules by E. Costa, Renna K, Rodrigues, Camila T, H. Campos, Jean C, Paradela, Luciana S, Dias, Marilia M, Novaes da Silva, Bianca, de Valega Negrao, Cyro von Zuben, Gonçalves, Kaliandra de Almeida, Ascenção, Carolline F. R, Adamoski, Douglas, Mercaldi, Gustavo Fernando, Bastos, Alliny C. S, Batista, Fernanda A. H, Figueira, Ana Carolina, Cordeiro, Artur T, Ambrosio, Andre L. B, Guido, Rafael V. C, Dias, Sandra M. G

“…The glutaminase (GLS) enzyme hydrolyzes glutamine into glutamate, an important anaplerotic source for the tricarboxylic acid cycle in rapidly growing cancer…”
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On the Denaturation Mechanisms of the Ligand Binding Domain of Thyroid Hormone Receptors by Martínez, Leandro, Souza, Paulo C. T, Garcia, Wanius, Batista, Fernanda A. H, Portugal, Rodrigo V, Nascimento, Alessandro S, Nakahira, Marcel, Lima, Luis M. T. R, Polikarpov, Igor, Skaf, Munir S

“…The ligand binding domain (LBD) of nuclear hormone receptors adopts a very compact, mostly α-helical structure that binds specific ligands with very high…”
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Camptosemin, a tetrameric lectin of Camptosema ellipticum: structural and functional analysis by Batista, Fernanda A. H, Goto, Leandro S, Garcia, Wanius, de Moraes, Derminda I, de Oliveira Neto, Mario, Polikarpov, Igor, Cominetti, Marcia R, Selistre-de-Araújo, Heloísa S, Beltramini, Leila M, Araújo, Ana Paula Ulian

“…Lectins have been classified into a structurally diverse group of proteins that bind carbohydrates and glycoconjugates with high specificity. They are…”
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