Search Results - "Batista, Denise da Gama Jaen"

Activities of Psilostachyin A and Cynaropicrin against Trypanosoma cruzi In Vitro and In Vivo by DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise, ZIMMERMANN, Stefanie, HAMBURGER, Matthias, BRUN, Reto, SCHÜHLY, Wolfgang, DE NAZARE CORREIA SOEIRO, Maria, DE ARAUJO, Julianna Siciliano, BATISTA, Marcos Meuser, LIONEL, Jessica, DE SOUZA, Elen Mello, HAMMER, Erica Ripoll, DA SILVA, Patricia Bernardino, DE MIERI, Maria, ADAMS, Michael

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Efficacy of sertraline against Trypanosoma cruzi : an in vitro and in silico study by Ferreira, Daiane Dias, Mesquita, Juliana Tonini, da Costa Silva, Thais Alves, Romanelli, Maiara Maria, da Gama Jaen Batista, Denise, da Silva, Cristiane França, da Gama, Aline Nefertiti Silva, Neves, Bruno Junior, Melo-Filho, Cleber Camilo, Correia Soeiro, Maria de Nazare, Andrade, Carolina Horta, Tempone, Andre Gustavo

“…Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. In this work, we studied the…”
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Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo by Batista, Denise da Gama Jaén, Batista, Marcos Meuser, de Oliveira, Gabriel Melo, Britto, Constança Carvalho, Rodrigues, Ana Carolina Mondaine, Stephens, Chad E, Boykin, David W, Soeiro, Maria de Nazaré Correia

“…Chagas disease caused by Trypanosoma cruzi is an important cause of mortality and morbidity in Latin America but no vaccines or safe chemotherapeutic agents…”
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Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies by XIAOHUA ZHU, QIANG LIU, STEPHENS, Chad E, BANERJEE, Moloy, FARAHAT, Abdelbasset A, MUNDE, Manoj, DAVID WILSON, W, BOYKIN, David W, ZHUO WANG, Michael, WERBOVETZ, Karl A, SIHYUNG YANG, PARMAN, Toufan, GREEN, Carol E, MIRSALIS, Jon C, DE NAZARE CORREIA SOEIRO, Maria, DE SOUZA, Elen Mello, DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise

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Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection by da Silva, Cristiane França, Batista, Denise da Gama Jaén, de Araújo, Julianna Siciliano, Cunha-Junior, Edézio Ferreira, Stephens, Chad E, Banerjee, Moloy, Farahat, Abdelbasset A, Akay, Senol, Fisher, Mary K, Boykin, David W, Soeiro, Maria de Nazaré Correia

“…Arylimidamides (AIAs), previously termed as reversed amidines, present a broad spectrum of activity against intracellular microorganisms. In the present study,…”
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Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi by de Araújo, Julianna Siciliano, França da Silva, Cristiane, Batista, Denise da Gama Jaén, Nefertiti, Aline, Fiuza, Ludmila Ferreira de Almeida, Fonseca-Berzal, Cristina Rosa, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sijm, Maarten, Kalejaiye, Titilola D, de Koning, Harry P, Maes, Louis, Sterk, Geert Jan, Leurs, Rob, Soeiro, Maria de Nazaré Correia

“…Pyrazolones are heterocyclic compounds with interesting biological properties. Some derivatives inhibit phosphodiesterases (PDEs) and thereby increase the…”
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Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi by Hoekstra, William J, Hargrove, Tatiana Y, Wawrzak, Zdzislaw, da Gama Jaen Batista, Denise, da Silva, Cristiane F, Nefertiti, Aline S G, Rachakonda, Girish, Schotzinger, Robert J, Villalta, Fernando, Soeiro, Maria de Nazaré C, Lepesheva, Galina I

“…A novel antifungal drug candidate, the 1-tetrazole-based agent VT-1161…”
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In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi by DE NAZARE CORREIA SOEIRO, Maria, DE SOUZA, Elen Mello, BRITTO, Constança, KWANGHO KIM, SULIKOWSKI, Gary, HARGROVE, Tatiana Y, WATERMAN, Michael R, LEPESHEVA, Galina I, DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise, BATISTA, Marcos Meuser, PAVAO, Beatriz Philot, ARAUJO, Julianna Siciliano, AIUB, Claudia Alessandra Fortes, DA SILVA, Patricia Bernardino, LIONEL, Jessica

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Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas' Disease Treatment by DA GAMA JAEN BATISTA, Denise, MEUSER BATISTA, Marcos, STEPHENS, Chad E, BOYKIN, David W, CORREIA SOEIRO, Maria De Nazaré, MELO DE OLIVEIRA, Gabriel, BORGES DO AMARAL, Patricia, LANNES-VIEIRA, Joseli, CARVALHO BRITTO, Constanca, JUNQUEIRA, Angela, LIMA, Marli Maria, ROMANHA, Alvaro José, SALES JUNIOR, Policarpo Ademar

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In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection by da Silva, Cristiane França, Batista, Denise da Gama Jaen, Oliveira, Gabriel Melo, de Souza, Elen Mello, Hammer, Erica Ripoll, da Silva, Patricia Bernardino, Daliry, Anissa, Araujo, Julianna Siciliano, Britto, Constança, Rodrigues, Ana Carolina Mondaine, Liu, Zongying, Farahat, Abdelbasset A, Kumar, Arvind, Boykin, David W, Soeiro, Maria de Nazaré Correia

“…Chagas disease is caused by infection with the intracellular protozoan parasite Trypanosoma cruzi. At present, nifurtimox and benznidazole, both compounds…”
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In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi by DA SILVA, Cristiane Franca, BATISTA, Marcos Meuser, JAEN BATISTA, Denise Da Gama, DE SOUZA, Elen Mello, DA SILVA, Patricia Bernardino, DE OLIVEIRA, Gabriel Melo, MEUSER, Andrea Souza, SHAREEF, Abdur-Rafay, BOYKIN, David W, SOEIRO, Maria De Nazare C

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Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity by Teixeira, Letícia R., Batista, Denise G. J., Louro, Sonia R. W., Muniz, Gabriel S. Vignoli, Gouvea, Ligiane R., Martins, Darliane A., Soeiro, Maria de Nazaré C.

“…Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2′-bipyridine (bipy)…”
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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds by Hargrove, Tatiana Y., Kim, Kwangho, de Nazaré Correia Soeiro, Maria, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Batista, Marcos Meuser, Yazlovitskaya, Eugenia M., Waterman, Michael R., Sulikowski, Gary A., Lepesheva, Galina I.

“…[Display omitted] • CYP51s (sterol 14alpha-demethylases) are efficient drug target enzymes. • CYP51s have a highly rigid substrate binding cavity. • CYP51…”
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Endocytic Pathway in Mouse Cardiac Cells by Maria de Nazaré Correia Soeiro, Mota, Renata Alves, Denise da Gama Jaen Batista, Maria de Nazareth Leal Meirelles

“…Primary cultures of heart muscle cells provide powerful tools for cardiac cell biological research that permits both physiological and biochemical approaches…”
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Discovery of Novel 7‑Aryl 7‑Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi by Hulpia, Fabian, Van Hecke, Kristof, França da Silva, Cristiane, da Gama Jaen Batista, Denise, Maes, Louis, Caljon, Guy, de Nazaré C. Soeiro, Maria, Van Calenbergh, Serge

“…Chagas disease is the leading cause of cardiac-related mortality in Latin American countries where it is endemic. Trypanosoma cruzi, the disease-causing…”
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In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi by Silva, Cristiane França da, Batista, Denise da Gama Jaen, Batista, Marcos Meuser, Lionel, Jessica, Hammer, Erica Ripoll, Brun, Reto, Soeiro, Maria de Nazaré Correia

“…Chagas disease (CD) is caused by the intracellular protozoan parasite Trypanosoma cruzi and affects more than 10 million people in poor areas of Latin America…”
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Discovery of Pyrrolo[2,3‑b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents by Lin, Cai, Hulpia, Fabian, da Silva, Cristiane França, Batista, Denise da Gama Jaen, Van Hecke, Kristof, Maes, Louis, Caljon, Guy, Soeiro, Maria de Nazaré C, Van Calenbergh, Serge

“…Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective…”
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Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection by Coutinho, Leticia, Ferreira, Marcelo Alves, Cosson, Alain, Batista, Marcos Meuser, Batista, Denise da Gama Jaén, Minoprio, Paola, Degrave, Wim M, Berneman, Armand, Soeiro, Maria de Nazaré Correia

“…Proline racemase is an important enzyme of Trypanosoma cruzi and has been shown to be an effective mitogen for B cells, thus contributing to the parasite's…”
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N6-modification of 7-Deazapurine nucleoside analogues as Anti-Trypanosoma cruzi and anti-Leishmania agents: Structure-activity relationship exploration and In vivo evaluation by Lin, Cai, Jaén Batista, Denise da Gama, Mazzeti, Ana Lia, Donola Girão, Roberson, de Oliveira, Gabriel Melo, Karalic, Izet, Hulpia, Fabian, Soeiro, Maria de Nazaré C., Maes, Louis, Caljon, Guy, Van Calenbergh, Serge

“…Chagas disease and leishmaniasis are two poverty-related neglected tropical diseases that cause high mortality and morbidity. Current treatments suffer from…”
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N6-methyltubercidin gives sterile cure in a cutaneous Leishmania amazonensis mouse model by Present, Cassandra, Girão, Roberson Donola, Lin, Cai, Caljon, Guy, Van Calenbergh, Serge, Moreira, Otacilio, Ruivo, Leonardo Alexandre de Souza, Batista, Marcos Meuser, Azevedo, Raquel, Batista, Denise da Gama Jaen, Soeiro, Maria de Nazaré Correia

“…Leishmania is a trypanosomatid parasite that causes skin lesions in its cutaneous form. Current therapies rely on old and expensive drugs, against which the…”
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