Search Results - "Bathe, Oliver F"

Cancer-Associated Muscle Wasting-Candidate Mechanisms and Molecular Pathways by Armstrong, Victoria S, Fitzgerald, Liam W, Bathe, Oliver F

“…Excessive muscle loss is commonly observed in cancer patients and its association with poor prognosis has been well-established. Cancer-associated sarcopenia…”
Get full text

A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics by Farshidfar, Farshad, Weljie, Aalim M, Kopciuk, Karen A, Hilsden, Robert, McGregor, S Elizabeth, Buie, W Donald, MacLean, Anthony, Vogel, Hans J, Bathe, Oliver F

“…Background: Timely diagnosis and classification of colorectal cancer (CRC) are hindered by unsatisfactory clinical assays. Our aim was to construct a…”
Get full text

Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas by Stretch, Cynthia, Aubin, Jean-Michel, Mickiewicz, Beata, Leugner, Derek, Al-Manasra, Tariq, Tobola, Elizabeth, Salazar, Santiago, Sutherland, Francis R, Ball, Chad G, Dixon, Elijah, Vogel, Hans J, Damaraju, Sambasivario, Baracos, Vickie E, Bathe, Oliver F

“…Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low…”
Get full text

Prognostic value of early changes in CT-measured body composition in patients receiving chemotherapy for unresectable pancreatic cancer by Salinas-Miranda, Emmanuel, Deniffel, Dominik, Dong, Xin, Healy, Gerard M., Khalvati, Farzad, O’Kane, Grainne M., Knox, Jennifer, Bathe, Oliver F., Baracos, Vickie E., Gallinger, Steven, Haider, Masoom A.

“…Objectives Skeletal muscle mass is a prognostic factor in pancreatic ductal adenocarcinoma (PDAC). However, it remains unclear whether changes in body…”
Get full text

Feasibility of Identifying Pancreatic Cancer Based on Serum Metabolomics by BATHE, Oliver F, SHAYKHUTDINOV, Rustem, KOPCIUK, Karen, WELJIE, Aalim M, MCKAY, Andrew, SUTHERLAND, Francis R, DIXON, Elijah, DUNSE, Nicole, SOTIROPOULOS, Dina, VOGEL, Hans J

“…We postulated that the abundance of various metabolites in blood would facilitate the diagnosis of pancreatic and biliary lesions, which could potentially…”
Get full text

A quantitative multimodal metabolomic assay for colorectal cancer by Farshidfar, Farshad, Kopciuk, Karen A, Hilsden, Robert, McGregor, S Elizabeth, Mazurak, Vera C, Buie, W Donald, MacLean, Anthony, Vogel, Hans J, Bathe, Oliver F

“…Early diagnosis of colorectal cancer (CRC) simplifies treatment and improves treatment outcomes. We previously described a diagnostic metabolomic biomarker…”
Get full text

Lipid is heterogeneously distributed in muscle and associates with low radiodensity in cancer patients by Bhullar, Amritpal S., Anoveros‐Barrera, Ana, Dunichand‐Hoedl, Abha, Martins, Karen, Bigam, David, Khadaroo, Rachel G., McMullen, Todd, Bathe, Oliver F., Putman, Charles T., Clandinin, Michael T., Baracos, Vickie E., Mazurak, Vera C.

“…Background Low muscle radiodensity is associated with mortality in a variety of cancer types. Biochemical and morphological correlates are unknown. We aimed to…”
Get full text

A strategy for early detection of response to chemotherapy drugs based on treatment-related changes in the metabolome by Amin, Shahil, Rattner, Jodi, Keramati, Mohammad Reza, Farshidfar, Farshad, McNamara, Mairéad G, Knox, Jennifer J, Kopciuk, Karen, Vogel, Hans J, Bathe, Oliver F

“…We describe a biomarker-based approach to delivering chemotherapy that entails monitoring treatment changes in the circulating metabolome that reflect…”
Get full text

Identification of prognostic inflammatory factors in colorectal liver metastases by Hamilton, Trevor D, Leugner, Derek, Kopciuk, Karen, Dixon, Elijah, Sutherland, Francis R, Bathe, Oliver F

“…The modified Glasgow Prognostic Score (mGPS) has been reported to be an important prognostic indicator in a number of tumor types, including colorectal cancer…”
Get full text

Differentially expressed alternatively spliced genes in skeletal muscle from cancer patients with cachexia by Narasimhan, Ashok, Greiner, Russell, Bathe, Oliver F., Baracos, Vickie, Damaraju, Sambasivarao

“…Background Alternative splicing (AS) is a post‐transcriptional gene regulatory mechanism that contributes to proteome diversity. Aberrant splicing mechanisms…”
Get full text

A clinically useful and biologically informative genomic classifier for papillary thyroid cancer by Craig, Steven, Stretch, Cynthia, Farshidfar, Farshad, Sheka, Dropen, Alabi, Nikolay, Siddiqui, Ashar, Kopciuk, Karen, Park, Young Joo, Khalil, Moosa, Khan, Faisal, Harvey, Adrian, Bathe, Oliver F.

“…Clinical management of papillary thyroid cancer depends on estimations of prognosis. Standard care, which relies on prognostication based on clinicopathologic…”
Get full text

Effects of sample size on differential gene expression, rank order and prediction accuracy of a gene signature by Stretch, Cynthia, Khan, Sheehan, Asgarian, Nasimeh, Eisner, Roman, Vaisipour, Saman, Damaraju, Sambasivarao, Graham, Kathryn, Bathe, Oliver F, Steed, Helen, Greiner, Russell, Baracos, Vickie E

“…Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of…”
Get full text

Clinically impactful metabolic subtypes of pancreatic ductal adenocarcinoma (PDAC) by Pervin, Jannat, Asad, Mohammad, Cao, Shaolong, Jang, Gun Ho, Feizi, Nikta, Haibe-Kains, Benjamin, Karasinska, Joanna M., O’Kane, Grainne M., Gallinger, Steven, Schaeffer, David F., Renouf, Daniel J., Zogopoulos, George, Bathe, Oliver F.

“…Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by a diverse tumor microenvironment. The heterogeneous cellular…”
Get full text

Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data by Sheff, Joey G., Farshidfar, Farshad, Bathe, Oliver F., Kopciuk, Karen, Gentile, Francesco, Tuszynski, Jack, Barakat, Khaled, Schriemer, David C.

“…The mitotic kinesin Eg5 is an important target in cancer chemotherapy. A structurally diverse collection of canonical loop L5 inhibitors engage an allosteric…”
Get full text

Monitoring for Response to Antineoplastic Drugs: The Potential of a Metabolomic Approach by Rattner, Jodi, Bathe, Oliver F

“…For most cancers, chemotherapeutic options are rapidly expanding, providing the oncologist with substantial choices. Therefore, there is a growing need to…”
Get full text

A Population-Based Retrospective Study of Biliary Tract Cancers in Alberta, Canada by Beaulieu, Carissa, Lui, Arthur, Yusuf, Dimas, Abdelaziz, Zainab, Randolph, Brock, Batuyong, Eugene, Ghosh, Sunita, Bathe, Oliver F, Tam, Vincent, Spratlin, Jennifer L

“…Biliary tract cancers (BTC) are uncommon malignancies and are underrepresented in the literature. We performed a retrospective population-based review of adult…”
Get full text

Acute kidney injury following resection of hepatocellular carcinoma: prognostic value of the acute kidney injury network criteria by Bressan, Alexsander K., James, Matthew T., Dixon, Elijah, Bathe, Oliver F., Sutherland, Francis R., Ball, Chad G.

“…Acute kidney injury (AKI) is associated with increased morbidity and mortality after liver resection. Patients with hepatocellular carcinoma (HCC) have a…”
Get full text

A Framework for Development of Useful Metabolomic Biomarkers and Their Effective Knowledge Translation by Marchand, Calena R, Farshidfar, Farshad, Rattner, Jodi, Bathe, Oliver F

“…Despite the significant advantages of metabolomic biomarkers, no diagnostic tests based on metabolomics have been introduced to clinical use. There are many…”
Get full text

Clinical and biological characterization of skeletal muscle tissue biopsies of surgical cancer patients by Anoveros‐Barrera, Ana, Bhullar, Amritpal S., Stretch, Cynthia, Esfandiari, Nina, Dunichand‐Hoedl, Abha R., Martins, Karen J.B., Bigam, David, Khadaroo, Rachel G., McMullen, Todd, Bathe, Oliver F., Damaraju, Sambasivarao, Skipworth, Richard J., Putman, Charles T., Baracos, Vickie E., Mazurak, Vera C.

“…Background Researchers increasingly use intraoperative muscle biopsy to investigate mechanisms of skeletal muscle atrophy in patients with cancer. Muscles have…”
Get full text

Time-to-Surgery and Survival Outcomes in Resectable Colorectal Liver Metastases: A Multi-Institutional Evaluation by Leal, Julie N., MD, Bressan, Alexsander K., MD, Vachharajani, Neeta, BS, Gonen, Mithat, PhD, Kingham, T Peter, MD, D’Angelica, Michael I., MD, Allen, Peter J., MD, DeMatteo, Ronald P., MD, Doyle, Majella BM., MD, Bathe, Oliver F., MD, Greig, Paul D., MD, Wei, Alice, MDCM, MSc, FRCSC, FACS, Chapman, William C., MD, Dixon, Elijah, MD, Jarnagin, William R., MD

“…Abstract Background Resection of colorectal liver metastases(CRLM) is associated with improved survival; however, the impact of time to resection on survival…”
Get full text