Search Results - "Batey, Robert A."

Enamide Synthesis by Copper-Catalyzed Cross-Coupling of Amides and Potassium Alkenyltrifluoroborate Salts by Bolshan, Yuri, Batey, Robert A

“…A new partner: Potassium alkenyltrifluoroborate salts undergo coupling with amides to give enamides in the presence of a Cu(OAc)2 catalyst and under mild…”
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Parallel Synthesis of a Library of Benzoxazoles and Benzothiazoles Using Ligand-Accelerated Copper-Catalyzed Cyclizations of ortho-Halobenzanilides by Evindar, Ghotas, Batey, Robert A

“…A general method for the formation of benzoxazoles via a copper-catalyzed cyclization of ortho-haloanilides is reported. This approach complements the more…”
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Heterocycle Formation via Palladium-Catalyzed Intramolecular Oxidative C−H Bond Functionalization: An Efficient Strategy for the Synthesis of 2-Aminobenzothiazoles by Joyce, Laurie L, Batey, Robert A

“…N-Arylthioureas are converted to 2-aminobenzothiazoles via intramolecular C−S bond formation/C−H functionalization utilizing an unusual cocatalytic…”
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Regio- and Stereoselective Allylation and Crotylation of Indoles at C2 Through the Use of Potassium Organotrifluoroborate Salts by Nowrouzi, Farhad, Batey, Robert A.

“…A practical method for the allylation, prenylation, propargylation, and diastereoselective crotylation of indoles has been developed using air‐ and…”
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Functional characterization of a PROTAC directed against BRAF mutant V600E by Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, Goullet de Rugy, Theo, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank

“…The RAF family kinases function in the RAS–ERK pathway to transmit signals from activated RAS to the downstream kinases MEK and ERK. This pathway regulates…”
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Copper-Catalyzed Domino Annulation Approaches to the Synthesis of Benzoxazoles under Microwave-Accelerated and Conventional Thermal Conditions by Viirre, Russell D, Evindar, Ghotas, Batey, Robert A

“…Two domino annulation approaches for benzoxazole synthesis have been developed. In the first approach, copper-catalyzed intermolecular cross-coupling of…”
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A Short Total Synthesis of the Marine Sponge Pyrrole-2-aminoimidazole Alkaloid (±)-Agelastatin A by Duspara, Petar A., Batey, Robert A.

“…Ring by ring: (±)‐Agelastatin A has been synthesized through the use of domino and one‐pot reactions while minimizing protecting group usage. The core was…”
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Stereocontrolled Microwave-Assisted Domino [3,3]-Sigmatropic Reactions: A Winstein–Overman Rearrangement for the Formation of Differentiated Contiguous C–N Bonds by Tjeng, Andy A, Handore, Kishor L, Batey, Robert A

“…A domino [3,3]-sigmatropic rearrangement sequence employing a sequential reversible allylic azide rearrangement followed by an irreversible Overman reaction…”
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Total Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate-Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization To Avoid a Competing Thorpe–Ingold Effect Accelerated Transesterification by Chojnacka, Maja W, Batey, Robert A

“…A convergent total synthesis of (+)-prunustatin A is described through the assembly of two key fragments and a macrolactonization. Shiina MNBA couplings were…”
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An Approach to the 9‑Oxo-10-oxabicyclo[5.3.0]dec-2-ene Core of the Guaianolide and Pseudoguaianolide Sesquiterpenes via a Domino Electrocyclic Ring-Opening/Carboxylic Acid Trapping of a gem-Dibromocyclopropane by Kim, Simon J, Lough, Alan J, Batey, Robert A

“…A domino silver­(I)-promoted electrocyclic 2π-disrotatory electrocyclic ring-opening/intramolecular nucleophilic trapping of [n.1.0]-dibromocyclopropanes by…”
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Synthesis and Reactivity of N‑Alkyl Carbamoylimidazoles: Development of N‑Methyl Carbamoylimidazole as a Methyl Isocyanate Equivalent by Duspara, Petar A, Islam, Md. Sadequl, Lough, Alan J, Batey, Robert A

“…A high-yielding synthesis of N-methyl carbamoylimidazole from 1,1-carbonyldiimidazole (CDI) and MeNH3Cl is described. The product is a crystalline, readily…”
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An Organotrifluoroborate-Based Convergent Total Synthesis of the Potent Cancer Cell Growth Inhibitory Depsipeptides Kitastatin and Respirantin by Beveridge, Ramsay E., Batey, Robert A.

“…The total syntheses of the highly cytotoxic neo-antimycin macrocyclic depsipeptide natural products kitastatin and respirantin have been accomplished in a…”
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Terminal Alkyne Addition to Diazodicarboxylates: Synthesis of Hydrazide Linked Alkynes (Ynehydrazides) by Beveridge, Ramsay E, Batey, Robert A

“…A new route to form C sp –N bonds has been developed via addition of in situ generated lithium acetylides to sterically hindered diazodicarboxylates. The…”
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Enantioselective Palladium(II)-Catalyzed Formal [3,3]-Sigmatropic Rearrangement of 2-Allyloxypyridines and Related Heterocycles by Rodrigues, Alessandro, Lee, Ernest E, Batey, Robert A

“…Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of (E)- and (Z)-allyloxy substituted N-heterocycles generates N-allyl…”
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Copper- and Palladium-Catalyzed Intramolecular Aryl Guanidinylation:  An Efficient Method for the Synthesis of 2-Aminobenzimidazoles by Evindar, Ghotas, Batey, Robert A

“…The formation of 2-aminobenzimidazoles via intramolecular C−N bond formation between an aryl halide and a guanidine moiety can be achieved using either copper…”
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The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma by Xu, G. Wei, Ali, Mohsin, Wood, Tabitha E., Wong, Derek, Maclean, Neil, Wang, Xiaoming, Gronda, Marcela, Skrtic, Marko, Li, Xiaoming, Hurren, Rose, Mao, Xinliang, Venkatesan, Meenakshi, Zavareh, Reza Beheshti, Ketela, Troy, Reed, John C., Rose, David, Moffat, Jason, Batey, Robert A., Dhe-Paganon, Sirano, Schimmer, Aaron D.

“…The proteasomal pathway of protein degradation involves 2 discrete steps: ubiquitination and degradation. Here, we evaluated the effects of inhibiting the…”
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A Lanthanide(III) Triflate Mediated Macrolactonization/Solid-Phase Synthesis Approach for Depsipeptide Synthesis by Goodreid, Jordan D, dos Santos, Eduardo da Silveira, Batey, Robert A

“…The effect of dysprosium­(III) triflate on macrolactonization reactions to form depsipeptides using MNBA (Shiina’s reagent) is reported. Improved yields were…”
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A Hetero Diels–Alder Approach to the Synthesis of Chromans (3,4-Dihydrobenzopyrans) Using Oxonium Ion Chemistry: The Oxa-Povarov Reaction by Taylor, Rivka R. R, Batey, Robert A

“…An oxa analogue of the well-known Povarov reaction has been developed for the synthesis of 3,4-dihydrobenzopyrans (chromans). The reaction involves the formal…”
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The Pan-Canadian Chemical Library: A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening by Bedart, Corentin, Shimokura, Grace, West, Frederick G., Wood, Tabitha E., Batey, Robert A., Irwin, John J., Schapira, Matthieu

“…Computationally screening chemical libraries to discover molecules with desired properties is a common technique used in early-stage drug discovery. Recent…”
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Allylation and Crotylation of Ketones and Aldehydes Using Potassium Organotrifluoroborate Salts under Lewis Acid and Montmorillonite K10 Catalyzed Conditions by Nowrouzi, Farhad, Thadani, Avinash N, Batey, Robert A

“…Two convenient highly diastereoselective protocols for the allylation and crotylation of ketones using practical, air- and water-stable potassium allyl and…”
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