Search Results - "Bates, Ian R"

Myelin basic protein—diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis by Harauz, George, Ishiyama, Noboru, Hill, Christopher M.D, Bates, Ian R, Libich, David S, Farès, Christophe

“…The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin sheath in the central nervous system of higher vertebrates, and a member…”
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Membrane Lateral Diffusion and Capture of CFTR within Transient Confinement Zones by Bates, Ian R., Hébert, Benedict, Luo, Yishan, Liao, Jie, Bachir, Alexia I., Kolin, David L., Wiseman, Paul W., Hanrahan, John W.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) channel interacts with scaffolding and other proteins that are expected to restrict its lateral…”
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Membrane-anchoring and Charge Effects in the Interaction of Myelin Basic Protein with Lipid Bilayers Studied by Site-directed Spin Labeling by Bates, Ian R., Boggs, Joan M., Feix, Jimmy B., Harauz, George

“…Myelin basic protein (MBP) maintains the compaction of the myelin sheath in the central nervous system by anchoring the cytoplasmic face of the two apposing…”
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Effects of the osmolyte trimethylamine- N-oxide on conformation, self-association, and two-dimensional crystallization of myelin basic protein by Hill, Christopher M, Bates, Ian R, White, Gisele F, Ross Hallett, F, Harauz, G

“…The osmolyte trimethylamine- N-oxide (TMAO) is a naturally in vivo occurring “chemical chaperone” that has been shown to stabilise the folding of numerous…”
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An Arg/Lys→Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis by Bates, Ian R, Libich, David S, Wood, D.Denise, Moscarello, Mario A, Harauz, George

“…The degree of post-translational enzymatic deimination (conversion of arginyl to citrullinyl residues) of myelin basic protein (MBP) is correlated with the…”
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An Immunodominant Epitope of Myelin Basic Protein Is an Amphipathic α-Helix by Bates, Ian R., Feix, Jimmy B., Boggs, Joan M., Harauz, George

“…Myelin basic protein is a candidate autoantigen in multiple sclerosis. One of its dominant antigenic epitopes is segment Pro85 to Pro96 (human sequence…”
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Investigating membrane protein dynamics in living cells by Bates, Ian R, Wiseman, Paul W, Hanrahan, John W

“…Live cell imaging is a powerful tool for understanding the function and regulation of membrane proteins. In this review, we briefly discuss 4…”
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Effect of Arginine Loss in Myelin Basic Protein, as Occurs in Its Deiminated Charge Isoform, on Mediation of Actin Polymerization and Actin Binding to a Lipid Membrane in Vitro by Boggs, Joan M, Rangaraj, Godha, Hill, Christopher M. D, Bates, Ian R, Heng, Yew-Meng, Harauz, George

“…Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and is most likely responsible for adhesion…”
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Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)—diversity and conformational adaptability of MBP CaM-targets by Polverini, Eugenia, Boggs, Joan M., Bates, Ian R., Harauz, George, Cavatorta, Paolo

“…The classic 18.5 kDa isoform of murine myelin basic protein (mMBP) has been shown to bind calmodulin (CaM) strongly and specifically in vitro. Here, we have…”
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Molecular dynamics exposes alpha-helices in myelin basic protein by Bates, Ian R, Harauz, George

“…Molecular dynamics simulations of models of unmodified and deiminated MBP (myelin basic protein) have been performed on solvated structures with added…”
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The Effects of Deimination of Myelin Basic Protein on Structures Formed by Its Interaction with Phosphoinositide- Containing Lipid Monolayers by Ishiyama, Noboru, Bates, Ian R, Hill, Christopher M, Wood, D.Denise, Matharu, Philip, Viner, Nick J, Moscarello, Mario A, Harauz, George

“…The recombinant 18.5-kDa charge isoform of murine myelin basic protein (rmMBP) is unmodified posttranslationally and was used to study the effects of…”
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Characterization of a Recombinant Murine 18.5-kDa Myelin Basic Protein by Bates, Ian R., Matharu, Philip, Ishiyama, Noboru, Rochon, Denis, Wood, D.Denise, Polverini, Eugenia, Moscarello, Mario A., Viner, Nick J., Harauz, George

“…A recombinant hexahistidine-tagged 18.5-kDa isoform of murine myelin basic protein has been characterized biochemically and immunogenically, by mass…”
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The formation of helical tubular vesicles by binary monolayers containing a nickel-chelating lipid and phosphoinositides in the presence of basic polypeptides by Ishiyama, Noboru, Hill, Christopher M, Bates, Ian R, Harauz, George

“…Binary lipid monolayers consisting of equimolar proportions of a phosphoinositide and a nickel-chelating lipid formed helical tubular vesicular structures,…”
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Simultaneous Eulerian-Lagrangian velocity measurements of particulate pipe flow in transitional regime by Singh, Sanjay, Pothérat, Alban, Pringle, Chris C. T, Bates, Ian R. J, Holdsworth, Martin

“…We present a unique pipe flow rig capable where simultaneous particle tracking and flow velocity measurements in a dilute, neutrally buoyant particulate pipe…”
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Terminal deletion mutants of myelin basic protein: new insights into self-association and phospholipid interactions by Hill, Christopher M.D, Haines, Jeffery D, Antler, Christine E, Bates, Ian R, Libich, David S, Harauz, George

“…The 18.5 kDa isoform of myelin basic protein (MBP) has strong and probably specific interactions with phosphoinositides that are of interest regarding this…”
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Interaction of the 18.5‐kD isoform of myelin basic protein with Ca2+‐calmodulin: Effects of deimination assessed by intrinsic Trp fluorescence spectroscopy, dynamic light scattering, and circular dichroism by Libich, David S., Hill, Christopher M.D., Bates, Ian R., Hallett, F. Ross, Armstrong, Souzan, Siemiarczuk, Aleksander, Harauz, George

“…The effects of deimination (conversion of arginyl to citrullinyl residues) of myelin basic protein (MBP) on its binding to calmodulin (CaM) have been examined…”
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Regulation of CFTR on the Plasma Membrane by Abu-Arish, Asmahan, Bates, Ian R., Pandzic, Elvis, Ho, Angela, Hanrahan, John W., Wiseman, Paul W.

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Molecular dynamics exposes ?-helices in myelin basic protein by Bates, Ian R., Harauz, George

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An Immunodominant Epitope of Myelin Basic Protein Is an Amphipathic α-Helix by Ian R. Bates, Jimmy B. Feix, Joan M. Boggs, George Harauz

“…Myelin basic protein is a candidate autoantigen in multiple sclerosis. One of its dominant antigenic epitopes is segment Pro 85 to Pro 96 (human sequence…”
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Analogous structural motifs in myelin basic protein and in MARCKS by Harauz, G, Ishiyama, N, Bates, I R

“…Myelin basic protein (MBP) and myristoylated alanine-rich C-kinase substrate (MARCKS) are similar in terms of having extended conformations regulated by their…”
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