Search Results - "Batenburg, Wendy W."

(Pro)renin and its receptors: pathophysiological implications by Batenburg, Wendy W, Danser, A H Jan

“…Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin]. Since…”
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Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor by Batenburg, Wendy W, Krop, Manne, Garrelds, Ingrid M, de Vries, René, de Bruin, René JA, Burcklé, Celine A, Müller, Dominik N, Bader, Michael, Nguyen, Geneviève, Danser, AH Jan

“…OBJECTIVEMannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such binding contributes to renin/prorenin clearance but not to angiotensin…”
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Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats by Batenburg, Wendy W, Verma, Amrisha, Wang, Yunyang, Zhu, Ping, van den Heuvel, Mieke, van Veghel, Richard, Danser, A H Jan, Li, Qiuhong

“…Dysfunction of renin-angiotensin system (RAS) contributes to the pathogenesis of diabetic retinopathy (DR). Prorenin, the precursor of renin is highly elevated…”
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Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone by Roksnoer, Lodi C W, van Veghel, Richard, Clahsen-van Groningen, Marian C, de Vries, René, Garrelds, Ingrid M, Bhaggoe, Usha M, van Gool, Jeanette M G, Friesema, Edith C H, Leijten, Frank P J, Hoorn, Ewout J, Danser, A H Jan, Batenburg, Wendy W

“…ARNI [dual AT1 (angiotensin II type 1) receptor-neprilysin inhibition] exerts beneficial effects on blood pressure and kidney function in heart failure,…”
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Compound 21 Induces Vasorelaxation via an Endothelium- and Angiotensin II Type 2 Receptor-Independent Mechanism by Verdonk, Koen, Durik, Matej, Abd-Alla, Nalina, Batenburg, Wendy W, van den Bogaerdt, Antoon J, van Veghel, Richard, Roks, Anton J.M, Danser, A.H Jan, van Esch, Joep H.M

“…Angiotensin II type 2 (AT2) receptor stimulation has been linked to vasodilation. Yet, AT2 receptor-independent hypertension and hypotension (or no effect on…”
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Deterioration of kidney function by the (pro)renin receptor blocker handle region peptide in aliskiren-treated diabetic transgenic (mRen2)27 rats by te Riet, Luuk, van den Heuvel, Mieke, Peutz-Kootstra, Carine J, van Esch, Joep H M, van Veghel, Richard, Garrelds, Ingrid M, Musterd-Bhaggoe, Usha, Bouhuizen, Angelique M, Leijten, Frank P J, Danser, A H Jan, Batenburg, Wendy W

“…Dual renin-angiotensin system (RAS) blockade in diabetic nephropathy is no longer feasible because of the profit/side effect imbalance. (Pro)renin receptor…”
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Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries by BATENBURG, Wendy W, GARRELDS, Ingrid M, BERNASCONI, Catherine Chapuis, JUILLERAT-JEANNERET, Lucienne, VAN KATS, Jorge P, SAXENA, Pramod R, DANSER, A. H

“…Angiotensin (Ang) II type 2 (AT2) receptor stimulation results in coronary vasodilation in the rat heart. In contrast, AT2 receptor-mediated vasodilation could…”
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Long-lasting physiological antagonism of calcitonin gene-related peptide towards endothelin-1 in rat mesenteric arteries and human coronary arteries by Labruijere, Sieneke, Compeer, Matthijs G., van den Bogaerdt, Antoon J., van den Brink, Antoinette Maassen, De Mey, Jo G.R., Danser, A.H. Jan, Batenburg, Wendy W.

“…Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated…”
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Effects of angiotensin II and its metabolites in the rat coronary vascular bed : Is angiotensin III the preferred ligand of the angiotensin AT2 receptor? by VAN ESCH, Joep H. M, OOSTERVEER, Chantal R, BATENBURG, Wendy W, VAN VEGHEL, Richard, DANSER, A. H. Jan

“…Aminopeptidases metabolize angiotensin II to angiotensin-(2-8) (=angiotensin III) and angiotensin-(3-8) (=angiotensin IV), and carboxypeptidases generate…”
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The (pro)renin receptor: A new addition to the renin–angiotensin system? by Batenburg, Wendy W., Jan Danser, A.H.

“…The renin–angiotensin system is still incompletely understood. In particular, the function of prorenin, the inactive precursor of renin, is unknown. Yet,…”
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Method to develop a regional guide for the allergenic potential of tree pollen by De Weger, Letty A., Bakker-Jonges, Liesbeth E., De Groot, Hans, Kuppen, Henry H.J.M., Batenburg, Wendy W., Van Leeuwen, Anna, Koenders, Mieke, Van Vliet, Arnold J.H.

“…Allergic rhinitis, caused by airborne pollen, is a common disease with a great impact on the quality of life for patients and high costs for society…”
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Selective Angiotensin-Converting Enzyme C-Domain Inhibition Is Sufficient to Prevent Angiotensin I–Induced Vasoconstriction by van Esch, Joep H.M, Tom, Beril, Dive, Vincent, Batenburg, Wendy W, Georgiadis, Dimitris, Yiotakis, Athanasios, van Gool, Jeanette M.G, de Bruijn, René J.A, de Vries, René, Danser, A H. Jan

“…Somatic angiotensin-converting enzyme (ACE) contains 2 domains (C-domain and N-domain) capable of hydrolyzing angiotensin I (Ang I) and bradykinin. Here we…”
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Specific Coronary Drug-Eluting Stents Interfere With Distal Microvascular Function After Single Stent Implantation in Pigs by van den Heuvel, Mieke, MD, MSc, Sorop, Oana, PhD, Batenburg, Wendy W., PhD, Bakker, Charlotte L., BSc, de Vries, René, BSc, Koopmans, Sietse Jan, PhD, van Beusekom, Heleen M.M., PhD, Duncker, Dirk J., MD, PhD, Danser, A.H. Jan, PhD, van der Giessen, Willem J., MD, PhD

“…Objectives The aim of this study was to compare the effects of single drug-eluting stents (DES) on porcine coronary function distal to the stent in vivo and in…”
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Prorenin and Renin-Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide by Feldt, Sandra, Batenburg, Wendy W, Mazak, Istvan, Maschke, Ulrike, Wellner, Maren, Kvakan, Heda, Dechend, Ralf, Fiebeler, Anette, Burckle, Celine, Contrepas, Aurelie, Danser, A H. Jan, Bader, Michael, Nguyen, Genevieve, Luft, Friedrich C, Muller, Dominik N

“…The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes…”
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Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney by VAN DEN HEUVEL, Mieke, BATENBURG, Wendy W, JAINANDUNSING, Sjaam, GARRELDS, Ingrid M, VAN GOOL, Jeanette M. G, FEELDERS, Richard A, VAN DEN MEIRACKER, Anton H, JAN DANSER, A. H

“…To study which renin-angiotensin-aldosterone system (RAAS) component best reflects renal RAAS activity. We measured urinary and plasma renin, prorenin,…”
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Renin- and Prorenin-Induced Effects in Rat Vascular Smooth Muscle Cells Overexpressing the Human (Pro)Renin Receptor: Does (Pro)Renin-(Pro)Renin Receptor Interaction Actually Occur? by Batenburg, Wendy W, Lu, Xifeng, Leijten, Frank, Maschke, Ulrike, Müller, Dominik N, Danser, A.H Jan

“…Renin/prorenin binding to the (pro)renin receptor ([P]RR) results in direct (angiotensin-independent) second-messenger activation in vitro, whereas in vivo…”
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Endothelium-derived hyperpolarizing factor and protein kinase G Iα activation: H 2 O 2 versus S-nitrosothiols by Bautista-Niño, Paula K, van der Stel, Marien, Batenburg, Wendy W, de Vries, René, Roks, Anton J M, Danser, A H Jan

“…Protein kinase G (PKG) Iα mediates the cyclic guanosine monophosphate-mediated vasodilatory effects induced by NO. Endothelium-derived hyperpolarizing factors…”
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Endothelium-derived hyperpolarizing factor and protein kinase G Iα activation: H2O2 versus S-nitrosothiols by Bautista-Niño, Paula K., van der Stel, Marien, Batenburg, Wendy W., de Vries, René, Roks, Anton J.M., Danser, A.H. Jan

“…Protein kinase G (PKG) Iα mediates the cyclic guanosine monophosphate-mediated vasodilatory effects induced by NO. Endothelium-derived hyperpolarizing factors…”
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Beneficial Effects of Combined AT1 Receptor/Neprilysin Inhibition (ARNI) Versus AT1 Receptor Blockade Alone in the Diabetic Eye by Prasad, Tuhina, Roksnoer, Lodi C W, Zhu, Ping, Verma, Amrisha, Li, Yiming, Batenburg, Wendy W, de Vries, René, Danser, A H Jan, Li, Qiuhong

“…Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial…”
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The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 rats by Batenburg, Wendy W, van den Heuvel, Mieke, van Esch, Joep H.M, van Veghel, Richard, Garrelds, Ingrid M, Leijten, Frank, Danser, Alexander H.J

“…BACKGROUND:Elevated prorenin levels associate with microvascular complications in patients with diabetes mellitus, possibly because prorenin affects vascular…”
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