Search Results - "Bateman, Randall J"

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease by Barthélemy, Nicolas R, Horie, Kanta, Sato, Chihiro, Bateman, Randall J

“…Highly sensitive and specific plasma biomarkers for Alzheimer's disease (AD) have the potential to improve diagnostic accuracy in the clinic and facilitate…”
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CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease by Horie, Kanta, Barthélemy, Nicolas R, Sato, Chihiro, Bateman, Randall J

“…Tau is a microtubule associated protein in the brain that aggregates in Alzheimer's disease to form pathological tangles and neurites. Insoluble tau aggregates…”
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Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring by Ashton, Nicholas J., Janelidze, Shorena, Mattsson-Carlgren, Niklas, Binette, Alexa Pichet, Strandberg, Olof, Brum, Wagner S., Karikari, Thomas K., González-Ortiz, Fernándo, Di Molfetta, Guglielmo, Meda, Francisco J., Jonaitis, Erin M., Koscik, Rebecca Langhough, Cody, Karly, Betthauser, Tobey J., Li, Yan, Vanmechelen, Eugeen, Palmqvist, Sebastian, Stomrud, Erik, Bateman, Randall J., Zetterberg, Henrik, Johnson, Sterling C., Blennow, Kaj, Hansson, Oskar

“…Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers…”
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Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study by McDade, Eric, Cummings, Jeffrey L, Dhadda, Shobha, Swanson, Chad J, Reyderman, Larisa, Kanekiyo, Michio, Koyama, Akihiko, Irizarry, Michael, Kramer, Lynn D, Bateman, Randall J

“…Lecanemab, a humanized IgG1 monoclonal antibody that targets soluble aggregated Aβ species (protofibrils), has demonstrated robust brain fibrillar amyloid…”
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Reply to Suvorexant for Preventing Alzheimer's Disease by Lucey, Brendan P., Bateman, Randall J.

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Loss of Brain Aerobic Glycolysis in Normal Human Aging by Goyal, Manu S., Vlassenko, Andrei G., Blazey, Tyler M., Su, Yi, Couture, Lars E., Durbin, Tony J., Bateman, Randall J., Benzinger, Tammie L.-S., Morris, John C., Raichle, Marcus E.

“…The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we…”
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Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease by Barthélemy, Nicolas R, Mallipeddi, Nipun, Moiseyev, Paul, Sato, Chihiro, Bateman, Randall J

“…Tau protein aggregation into neurofibrillary tangles in the central nervous system contributes to the etiology of certain neurodegenerative disorders,…”
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Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury by Suárez-Calvet, Marc, Araque Caballero, Miguel Ángel, Kleinberger, Gernot, Bateman, Randall J, Fagan, Anne M, Morris, John C, Levin, Johannes, Danek, Adrian, Ewers, Michael, Haass, Christian

“…Emerging evidence supports a role for innate immunity and microglia in Alzheimer's disease (AD) pathophysiology. However, no marker related to microglia has…”
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Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification by Barthélemy, Nicolas R, Bateman, Randall J, Hirtz, Christophe, Marin, Philippe, Becher, François, Sato, Chihiro, Gabelle, Audrey, Lehmann, Sylvain

“…Cerebrospinal fluid biomarker profiles characterized by decreased amyloid-beta peptide levels and increased total and phosphorylated tau levels at threonine…”
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Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau by Mattsson‐Carlgren, Niklas, Janelidze, Shorena, Bateman, Randall J, Smith, Ruben, Stomrud, Erik, Serrano, Geidy E, Reiman, Eric M, Palmqvist, Sebastian, Dage, Jeffrey L, Beach, Thomas G, Hansson, Oskar

“…Alzheimer’s disease is characterized by β‐amyloid plaques and tau tangles. Plasma levels of phospho‐tau217 (P‐tau217) accurately differentiate Alzheimer’s…”
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Persistent metabolic youth in the aging female brain by Goyal, Manu S., Blazey, Tyler M., Su, Yi, Couture, Lars E., Durbin, Tony J., Bateman, Randall J., Benzinger, Tammie L.-S., Morris, John C., Raichle, Marcus E., Vlassenko, Andrei G.

“…Sex differences influence brain morphology and physiology during both development and aging. Here we apply a machine learning algorithm to a multiparametric…”
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Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease by Bateman, Randall J., Smith, Janice, Donohue, Michael C., Delmar, Paul, Abbas, Rachid, Salloway, Stephen, Wojtowicz, Jakub, Blennow, Kaj, Bittner, Tobias, Black, Sandra E., Klein, Gregory, Boada, Mercè, Grimmer, Timo, Tamaoka, Akira, Perry, Richard J., Turner, R. Scott, Watson, David, Woodward, Michael, Thanasopoulou, Angeliki, Lane, Christopher, Baudler, Monika, Fox, Nick C., Cummings, Jeffrey L., Fontoura, Paulo, Doody, Rachelle S.

“…In two randomized trials, the use of gantenerumab (an anti-Aβ monoclonal antibody) did not lead to slower clinical decline than placebo over 116 weeks among…”
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Another step forward in blood-based diagnostics for Alzheimer’s disease by Bateman, Randall J., Barthélemy, Nicolas R., Horie, Kanta

“…Measurement of phosphorylated tau protein in blood plasma allows Alzheimer’s disease to be distinguished from other neurological diseases and may assist in…”
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The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer's disease: a literature review by Brand, Abby L, Lawler, Paige E, Bollinger, James G, Li, Yan, Schindler, Suzanne E, Li, Melody, Lopez, Samir, Ovod, Vitaliy, Nakamura, Akinori, Shaw, Leslie M, Zetterberg, Henrik, Hansson, Oskar, Bateman, Randall J

“…The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD). Detection of Aβ pathology is essential for AD…”
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White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network by Lee, Seonjoo, Viqar, Fawad, Zimmerman, Molly E., Narkhede, Atul, Tosto, Giuseppe, Benzinger, Tammie L.S., Marcus, Daniel S., Fagan, Anne M., Goate, Alison, Fox, Nick C., Cairns, Nigel J., Holtzman, David M., Buckles, Virginia, Ghetti, Bernardino, McDade, Eric, Martins, Ralph N., Saykin, Andrew J., Masters, Colin L., Ringman, John M., Ryan, Natalie S., Förster, Stefan, Laske, Christoph, Schofield, Peter R., Sperling, Reisa A., Salloway, Stephen, Correia, Stephen, Jack Jr, Clifford, Weiner, Michael, Bateman, Randall J., Morris, John C., Mayeux, Richard, Brickman, Adam M.

“…Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐weighted magnetic resonance imaging (MRI) scans that most commonly reflect…”
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The case for low-level BACE1 inhibition for the prevention of Alzheimer disease by McDade, Eric, Voytyuk, Iryna, Aisen, Paul, Bateman, Randall J., Carrillo, Maria C., De Strooper, Bart, Haass, Christian, Reiman, Eric M., Sperling, Reisa, Tariot, Pierre N., Yan, Riqiang, Masters, Colin L., Vassar, Robert, Lichtenthaler, Stefan F.

“…Alzheimer disease (AD) is the most common cause of dementia in older individuals (>65 years) and has a long presymptomatic phase. Preventive therapies for AD…”
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Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease by Bateman, Randall J, Xiong, Chengjie, Benzinger, Tammie L.S, Fagan, Anne M, Goate, Alison, Fox, Nick C, Marcus, Daniel S, Cairns, Nigel J, Xie, Xianyun, Blazey, Tyler M, Holtzman, David M, Santacruz, Anna, Buckles, Virginia, Oliver, Angela, Moulder, Krista, Aisen, Paul S, Ghetti, Bernardino, Klunk, William E, McDade, Eric, Martins, Ralph N, Masters, Colin L, Mayeux, Richard, Ringman, John M, Rossor, Martin N, Schofield, Peter R, Sperling, Reisa A, Salloway, Stephen, Morris, John C

“…In this study of a cohort of adults with genetic mutations that cause autosomal dominant Alzheimer's disease, researchers identified abnormalities in…”
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CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease by Horie, Kanta, Salvadó, Gemma, Barthélemy, Nicolas R., Janelidze, Shorena, Li, Yan, He, Yingxin, Saef, Benjamin, Chen, Charles D., Jiang, Hong, Strandberg, Olof, Pichet Binette, Alexa, Palmqvist, Sebastian, Sato, Chihiro, Sachdev, Pallavi, Koyama, Akihiko, Gordon, Brian A., Benzinger, Tammie L. S., Holtzman, David M., Morris, John C., Mattsson-Carlgren, Niklas, Stomrud, Erik, Ossenkoppele, Rik, Schindler, Suzanne E., Hansson, Oskar, Bateman, Randall J.

“…Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau aggregates, drug…”
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Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls by Esparza, Thomas J., Zhao, Hanzhi, Cirrito, John R., Cairns, Nigel J., Bateman, Randall J., Holtzman, David M., Brody, David L.

“…Objective: Although amyloid‐beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer disease; soluble oligomeric Aβ has been…”
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The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model by Bateman, Randall J, Benzinger, Tammie L, Berry, Scott, Clifford, David B, Duggan, Cynthia, Fagan, Anne M, Fanning, Kathleen, Farlow, Martin R, Hassenstab, Jason, McDade, Eric M, Mills, Susan, Paumier, Katrina, Quintana, Melanie, Salloway, Stephen P, Santacruz, Anna, Schneider, Lon S, Wang, Guoqiao, Xiong, Chengjie

“…Abstract Introduction The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or…”
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