Search Results - "Bate, S. T."

Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding by Barnes, S.A., Young, J.W., Bate, S.T., Neill, J.C.

“…•Repeated PCP administration induced robust deficits in 5C-CPT performance.•Pre-treatment with dopamine D1 receptor partial agonist, SKF 38393, partially…”
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Characterisation of amyloid-induced inflammatory responses in the rat retina by Howlett, D. R., Bate, S. T., Collier, S., Lawman, A., Chapman, T., Ashmeade, T., Marshall, I., Anderson, P. J. B., Philpott, K. L., Richardson, J. C., Hille, C. J.

“…Amyloid-induced inflammation is thought to play a critical and early role in the pathophysiology of Alzheimer’s disease. As such, robust models with relevant…”
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Choosing cross-over designs when few subjects are available by Bate, S.T., Godolphin, E.J., Godolphin, J.D.

“…Cross-over designs are used extensively for experiments in many fields. If the n subjects are relatively scarce compared to the t treatments then universally…”
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The construction of nearly balanced and nearly strongly balanced uniform cross-over designs by Bate, S.T., Jones, B.

“…In this paper we consider the class of uniform cross-over designs. Existing results on the universal optimality of uniform cross-over designs are reviewed and…”
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The construction of multi-factor crossover designs in animal husbandry studies by Bate, S.T., Boxall, J.

“…For ethical reasons it is important to try to obtain as much useful information as possible from an animal experiment whilst minimizing the number of animals…”
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A review of uniform cross-over designs by Bate, S.T., Jones, B.

“…Uniform cross-over designs form an important family of experimental designs. They have been applied in many scientific disciplines including clinical trials,…”
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A review of uniform cross-over designs: Statistical Design and analysis in the health sciences III by BATE, S. T, JONES, B

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Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease by Pugh, Perdita L., Richardson, Jill C., Bate, Simon T., Upton, Neil, Sunter, David

“…Alzheimer's disease (AD) is characterised by progressive cognitive impairment with neuropsychiatric symptoms such as anomalous motor behaviour, depression,…”
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Cognitive correlates of Aβ deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes by Howlett, David R, Richardson, Jill C, Austin, Angela, Parsons, Andrew A, Bate, Simon T, Davies, D.Ceri, Gonzalez, M.Isabel

“…Several transgenic mouse models of Alzheimer's disease (AD) have been developed that exhibit β-amyloid (Aβ) neuropathology and behavioural deficits. However,…”
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Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study by Sharp, Caroline J, Reeve, Alison J, Collins, Sue D, Martindale, Jo C, Summerfield, Scott G, Sargent, Becky S, Bate, Simon T, Chessell, Iain P

“…1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor…”
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GABAergic modulation of 5-HT7 receptor-mediated effects on 5-HT efflux in the guinea-pig dorsal raphe nucleus by Roberts, Claire, Thomas, David R, Bate, Simon T, Kew, James N C

“…5-HT(7) receptor mRNA and protein are localised in the dorsal raphe nucleus (DRN) on non-serotonergic neurones. The effect of 5-HT(7) receptor antagonism on…”
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Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APPxPS1 mice using MRI by Maheswaran, S, Barjat, H, Rueckert, D, Bate, ST, Howlett, DR, Tilling, L, Smart, S C, Pohlmann, A, Richardson, J C, Hartkens, T, Hill, DLG, Upton, N, Hajnal, J V, James, M F

“…In humans, mutations of amyloid precursor protein (APP) and presenilins (PS) 1 and 2 are associated with amyloid deposition, brain structural change and…”
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Locomotor reactivity to a novel environment and sensitivity to MK-801 in five strains of mice by Kalinichev, Mikhail, Bate, Simon T, Coggon, Sara A, Jones, Declan N.C

“…The ability of a noncompetitive antagonist of the N-methyl-D-aspartate receptor, MK-801, to stimulate locomotor activity (LMA) in mice was compared across…”
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Investigation into the role of P2X sub(3)/P2X sub(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study by Sharp, C J, Reeve, A J, Collins, S D, Martindale, J C, Summerfield, S G, Sargent, B S, Bate, ST, Chessell, I P

“…Two P2X sub(3)/P2X sub(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. A-317491 has…”
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MRI quantification in vivo of corticosteroid induced thymus involution in mice: Correlation with ex vivo measurements by Brooks, Keith J., Bunce, Keith T., Haase, Michael V., White, Alan, Kumar Changani, K., Bate, Simon T., Reid, David G.

“…Thymus involution is a useful marker of transactivation-mediated side effects in preclinical therapeutic index testing of new anti-inflammatory…”
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The inhibitory effect of CtBP-interacting protein on the oxidative damage of cerebral endothelia cells by Du, G J, Geng, Dangmurenjiafu, Fan, Y D, Su, R Q, Bate, Gonggaoang

“…To explore the effect of CtBP-Interacting protein (CtIP) on oxidative damage of cerebral endothelia cells and its mechanism. Cerebral endothelia cells were…”
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Effects of total flavonids of astragalus on arrhythmia,endoplasmic reticulum stress in mice with viral myocarditis by Liu, Hao, Hurile, Bate, Xiong, Ying, Wei, Cheng-Xi, Xuan, Li-Ying, Wang, Yu, Zhao, Ming

“…To investigate the effects of total flavonids of astragalus(TFA) on arrhythmia, endoplasmic reticulum stress and connexcin in mice with viral myocarditis and…”
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Epidemiological survey of allergic rhinitis in steppe area of Xilingol League, Inner Mongolian of China by Zhuang, Yan, Ma, Tingting, Kang, Zhenxiang, Siqin, Bate, Yan, Weijun, Bai, Yongfei, Shan, Guangliang, Wang, Xueyan

“…To investigate the epidemiologic feature of allergic rhinitis （AR） in the grassland area of Xilin Gol League, in Inner Mongolia, including prevalence rate,…”
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