Search Results - "Bate, Clive"

Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures by Bate, Clive, Williams, Alun

“…Alzheimer's disease is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) in the brain. Aβ oligomers are believed to…”
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Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation by Bate, Clive, Nolan, William, Williams, Alun

“…The prion diseases occur following the conversion of the cellular prion protein (PrPC) into disease-related isoforms (PrPSc). In this study, the role of the…”
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Can we switch production of toxic Aβ oligomers to neuroprotective Aβ monomers to allow synapse regeneration by Bate, Clive

“…Alzheimer＇s disease （AD） is a complex neurological disor- der characterized by a progressive dementia. The amyloid hypothesis states that pathogenesis is…”
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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses by Bate, Clive, Nolan, William, McHale-Owen, Harriet, Williams, Alun

“…Although the cellular prion protein (PrPC) is concentrated at synapses, the factors that target PrPC to synapses are not understood. Here we demonstrate that…”
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Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration by Bate, Clive

“…The amyloid hypothesis of Alzheimer＇s disease （AD） pathogen- esis maintains that the key event is the production of specific C-terminal amyloid-β （Aβ） peptides…”
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GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice by Puig, Berta, Altmeppen, Hermann C, Linsenmeier, Luise, Chakroun, Karima, Wegwitz, Florian, Piontek, Ulrike K, Tatzelt, Jörg, Bate, Clive, Magnus, Tim, Glatzel, Markus

“…The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical…”
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α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2 by Bate, Clive, Williams, Alun

“…The accumulation of aggregated forms of the α-synuclein (αSN) is associated with the pathogenesis of Parkinson's disease (PD) and Dementia with Lewy Bodies…”
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cAMP-Inhibits Cytoplasmic Phospholipase A₂ and Protects Neurons against Amyloid-β-Induced Synapse Damage by Bate, Clive, Williams, Alun

“…A key event in Alzheimer's disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage…”
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The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication by Bate, Clive, Tayebi, Mourad, Williams, Alun

“…The prion diseases occur following the conversion of the cellular prion protein (PrPC) into an alternatively folded, disease-associated isoform (PrPSc)…”
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Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity by Bate, Clive, Salmona, Mario, Diomede, Luisa, Williams, Alun

“…A key feature of prion diseases is the conversion of the normal, cellular prion protein (PrPC) into β-sheet-rich disease-related isoforms (PrPSc), the…”
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A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell lines by Jones, Daryl Rhys, Taylor, William Alexander, Bate, Clive, David, Monique, Tayebi, Mourad

“…The development of antibodies effective in crossing the blood brain barrier (BBB), capable of accessing the cytosol of affected cells and with higher affinity…”
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Glycosylphosphatidylinositols: More than just an anchor? by Bate, Clive, Nolan, William, Williams, Alun

“…There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically…”
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Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage by West, Ewan, Osborne, Craig, Nolan, William, Bate, Clive

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation…”
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Interferon-γ increases neuronal death in response to amyloid-β1-42 by Bate, Clive, Kempster, Sarah, Last, Victoria, Williams, Alun

“…BACKGROUND: Alzheimer's disease is a neurodegenerative disorder characterized by a progressive cognitive impairment, the consequence of neuronal dysfunction…”
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Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A2 and synapse damage by Bate, Clive, Williams, Alun

“…Precisely how the accumulation of PrP Sc causes the neuronal degeneration that leads to the clinical symptoms of prion diseases is poorly understood. Our…”
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Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation by Bate, Clive, Tayebi, Mourad, Williams, Alun

“…The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion…”
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Phospholipase A2 Inhibitors or Platelet-activating Factor Antagonists Prevent Prion Replication by Bate, Clive, Reid, Stuart, Williams, Alun

“…A key feature of prion diseases is the conversion of the cellular prion protein (PrP C ) into disease-related isoforms (PrP Sc ), the deposition of which is…”
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The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation by Bate, Clive, Williams, Alun

“…The prion diseases occur following the conversion of the cellular prion protein (PrPC) into a disease-related isoform (PrPSc). In this study a cell painting…”
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Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage by Bate, Clive, Rumbold, Louis, Williams, Alun

“…Platelet-activating factor (PAF) is implicated in the neuronal damage that accompanies ischemia, prion disease and Alzheimer's disease (AD). Since some…”
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Polyunsaturated Fatty Acids Protect Against Prion-Mediated Synapse Damage In Vitro by Bate, Clive, Tayebi, Mourad, Salmona, Mario, Diomede, Luisa, Williams, Alun

“…A loss of synapses is characteristic of the early stages of the prion diseases. Here we modelled the synapse damage that occurs in prion diseases by measuring…”
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