Search Results - "Batchelor, K"

Anticancer Potential of Diiron Vinyliminium Complexes by Rocco, Dalila, Batchelor, Lucinda K., Agonigi, Gabriele, Braccini, Simona, Chiellini, Federica, Schoch, Silvia, Biver, Tarita, Funaioli, Tiziana, Zacchini, Stefano, Biancalana, Lorenzo, Ruggeri, Marina, Pampaloni, Guido, Dyson, Paul J., Marchetti, Fabio

“…Although ferrocene derivatives have attracted considerable attention as possible anticancer agents, the medicinal potential of diiron complexes has remained…”
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Control of H- and J-Aggregate Formation via Host−Guest Complexation using Cucurbituril Hosts by Gadde, Suresh, Batchelor, Elizabeth K, Weiss, Joshua P, Ling, Yonghua, Kaifer, Angel E

“…The binding interactions between two cyanine dyes, pseudoisocyanine (PIC) and pinacyanol (PIN), and the cucurbit[n]uril hosts, cucurbit[7]uril (CB7) and…”
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Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children by Al-Obaidi, Issraa, Krome, Anna K, Wagner, Karl G, Pfarr, Kenneth, Kuesel, Annette C, Batchelor, Hannah K

“…It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate…”
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Mono-, Di- and Tetra-iron Complexes with Selenium or Sulphur Functionalized Vinyliminium Ligands: Synthesis, Structural Characterization and Antiproliferative Activity by Agonigi, Gabriele, Batchelor, Lucinda K, Ferretti, Eleonora, Schoch, Silvia, Bortoluzzi, Marco, Braccini, Simona, Chiellini, Federica, Biancalana, Lorenzo, Zacchini, Stefano, Pampaloni, Guido, Sarkar, Biprajit, Dyson, Paul J, Marchetti, Fabio

“…A series of diiron/tetrairon compounds containing a S- or a Se-function ( - , - , - , ), and the monoiron [FeCp(CO){SeC (NMe )C HC (Me)}] ( ) were prepared…”
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Acceptability of placebo multiparticulate formulations in children and adults by Lopez, Felipe L., Mistry, Punam, Batchelor, Hannah K., Bennett, Joanne, Coupe, Alastair, Ernest, Terry B., Orlu, Mine, Tuleu, Catherine

“…Patient acceptability is an important consideration in the design of medicines for children. The aim of this study was to investigate acceptability of…”
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Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny by Johnson, Trevor N., Batchelor, Hannah K., Goelen, Jan, Horniblow, Richard D., Dinh, Jean

“…Pediatric physiologically‐based modeling in drug development has grown in the past decade and optimizing the underlying systems parameters is important in…”
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The duality between particle methods and artificial neural networks by Alexiadis, A., Simmons, M. J. H., Stamatopoulos, K., Batchelor, H. K., Moulitsas, I.

“…The algorithm behind particle methods is extremely versatile and used in a variety of applications that range from molecular dynamics to astrophysics. For…”
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Controlling the Formation of Cyanine Dye H- and J-Aggregates with Cucurbituril Hosts in the Presence of Anionic Polyelectrolytes by Gadde, Suresh, Batchelor, Elizabeth K., Kaifer, Angel E.

“…Controlling aggregation: The formation of H‐ and J‐aggregates by cyanine dyes can be significantly enhanced by poly(styrenesulfonate) and further controlled…”
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Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline by Stamatopoulos, Konstantinos, O'Farrell, Connor, Simmons, Mark J H, Batchelor, Hannah K, Mistry, Nena

“…A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus 200 mg tablet) was developed and…”
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Publisher Correction: The duality between particle methods and artificial neural networks by Alexiadis, A., Simmons, M. J. H., Stamatopoulos, K., Batchelor, H. K., Moulitsas, I.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The Effect of Biorelevant Hydrodynamic Conditions on Drug Dissolution from Extended-Release Tablets in the Dynamic Colon Model by O'Farrell, Connor, Simmons, Mark J H, Batchelor, Hannah K, Stamatopoulos, Konstantinos

“…The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial…”
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Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging by Goelen, Jan, Alexander, Benoni, Wijesinghe, Haren Eranga, Evans, Emily, Pawar, Gopal, Horniblow, Richard D., Batchelor, Hannah K.

“…Previous studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small…”
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Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities by Schütt, Michael, Stamatopoulos, Konstantinos, Batchelor, Hannah K., Simmons, Mark J. H., Alexiadis, Alessio

“…For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug…”
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Influence of Food on Paediatric Gastrointestinal Drug Absorption Following Oral Administration: A Review by Batchelor, Hannah K

“…The objective of this paper was to review existing information regarding food effects on drug absorption within paediatric populations. Mechanisms that…”
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Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model by Schütt, Michael, O'Farrell, Connor, Stamatopoulos, Konstantinos, Hoad, Caroline L, Marciani, Luca, Sulaiman, Sarah, Simmons, Mark J H, Batchelor, Hannah K, Alexiadis, Alessio

“…The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these…”
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Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques by Stamatopoulos, Konstantinos, Karandikar, Sharad, Goldstein, Mark, O’Farrell, Connor, Marciani, Luca, Sulaiman, Sarah, Hoad, Caroline L., Simmons, Mark J. H., Batchelor, Hannah K.

“…This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion,…”
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Application of a Physiologically Based Pharmacokinetic Model to Predict Cefazolin and Cefuroxime Disposition in Obese Pregnant Women Undergoing Caesarean Section by Alrammaal, Hanadi H., Abduljalil, Khaled, Hodgetts Morton, Victoria, Morris, R. Katie, Marriott, John F., Chong, Hsu P., Batchelor, Hannah K.

“…Intravenous (IV) cefuroxime and cefazolin are used prophylactically in caesarean sections (CS). Currently, there are concerns regarding sub-optimal dosing in…”
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Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging by O’Farrell, Connor, Hoad, Caroline L., Stamatopoulos, Konstantinos, Marciani, Luca, Sulaiman, Sarah, Simmons, Mark J. H., Batchelor, Hannah K.

“…Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and…”
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Correction: Schütt et al. Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model. Pharmaceutics 2022, 14 , 184 by Schütt, Michael, O'Farrell, Connor, Stamatopoulos, Konstantinos, Hoad, Caroline L, Marciani, Luca, Sulaiman, Sarah, Simmons, Mark J H, Batchelor, Hannah K, Alexiadis, Alessio

“…In the original publication [...]…”
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New algorithm for the treatment of gastro‐oesophageal reflux disease by TYTGAT, G. N., MCCOLL, K., TACK, J., HOLTMANN, G., HUNT, R. H., MALFERTHEINER, P., HUNGIN, A. P. S., BATCHELOR, H. K.

“…Summary Background  Gastro‐oesophageal reflux disease (GERD) is associated with a variety of typical and atypical symptoms. Patients often present in the first…”
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