Search Results - "Bataller, Ramon"
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Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Published in Gastroenterology (New York, N.Y. 1943) (01-11-2011)“…Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can lead to fibrosis and cirrhosis. The latest surveillance report…”
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Alcoholic liver disease: pathogenesis and new targets for therapy
Published in Nature reviews. Gastroenterology & hepatology (01-09-2011)“…Despite its high prevalence worldwide, alcoholic liver disease (ALD) has attracted little attention in the past two decades. Abstinence has been the most…”
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The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Published in Nature reviews. Gastroenterology & hepatology (01-12-2023)“…Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the leading causes of chronic liver disease worldwide. NAFLD and ALD share…”
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Alcoholic hepatitis: Translational approaches to develop targeted therapies
Published in Hepatology (Baltimore, Md.) (01-10-2016)“…Alcoholic liver disease is a leading cause of liver‐related mortality worldwide. In contrast to recent advances in therapeutic strategies for patients with…”
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Pathophysiology and Management of Alcoholic Liver Disease: Update 2016
Published in Gut and liver (15-03-2017)“…Alcoholic liver disease (ALD) is a leading cause of cirrhosis, liver cancer, and acute and chronic liver failure and as such causes significant morbidity and…”
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Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy
Published in Journal of gastroenterology and hepatology (01-08-2013)“…Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease…”
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Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation
Published in Nature reviews. Gastroenterology & hepatology (01-01-2022)“…The prevalence of alcohol use disorder (AUD) has been steadily increasing over the past decade. In parallel, alcohol-associated liver disease (ALD) has been…”
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Pyroptosis by caspase11/4‐gasdermin‐D pathway in alcoholic hepatitis in mice and patients
Published in Hepatology (Baltimore, Md.) (01-05-2018)“…Alcoholic hepatitis (AH) continues to be a disease with high mortality and no efficacious medical treatment. Although severe AH is presented as acute on…”
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ACG Clinical Guideline: Alcohol-Associated Liver Disease
Published in The American journal of gastroenterology (01-01-2024)“…Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease and frequent indication for liver transplantation worldwide. With…”
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Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
Published in Gut (01-04-2020)“…Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease…”
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Rising Mortality From Alcohol-Associated Liver Disease in the United States in the 21st Century
Published in The American journal of gastroenterology (01-01-2020)“…In contrast with other developed nations, life expectancy is decreasing in the United States, in part due to increasing mortality from alcohol-associated liver…”
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Interleukin‐22 treatment ameliorates alcoholic liver injury in a murine model of chronic‐binge ethanol feeding: Role of signal transducer and activator of transcription 3
Published in Hepatology (Baltimore, Md.) (01-10-2010)“…Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines that is produced by Th17 and natural killer cells, plays an important…”
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Heavy daily alcohol intake at the population level predicts the weight of alcohol in cirrhosis burden worldwide
Published in Journal of hepatology (01-11-2016)“…Graphical abstract…”
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Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Published in Cancer cell (17-04-2012)“…Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the…”
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Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol‐Associated Liver Injury
Published in Alcoholism, clinical and experimental research (01-06-2020)“…Background Activation of NLRP3 in liver macrophages contributes to alcohol‐associated liver disease (ALD). Molecular chaperone heat shock protein (HSP) 90…”
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CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease
Published in Nature communications (09-12-2021)“…Complement receptor of immunoglobulin superfamily (CRIg) is expressed on liver macrophages and directly binds complement component C3b or Gram-positive…”
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Moderate Alcoholic Hepatitis
Published in Clinics in liver disease (01-08-2021)“…The natural history of moderate alcoholic hepatitis (AH) is not well known. It is a frequent disease with a probable underestimated incidence compared with its…”
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A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis
Published in Hepatology (Baltimore, Md.) (01-08-2017)“…The diagnosis of alcoholic hepatitis (AH) often requires a transjugular liver biopsy (TJLB), a procedure that is not always readily accessible. We analyzed…”
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Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis
Published in Hepatology (Baltimore, Md.) (01-02-2021)“…Background and Aims Alcoholic hepatitis (AH) is diagnosed by clinical criteria, although several objective scores facilitate risk stratification. Extracellular…”
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