A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity

In this work, iron oxide (Fe 3 O 4 ) magnetic nanoparticles (MNPs) and graphene oxide (GO) nanosheets were prepared via the co-precipitation technique and the Modified Hummer method. Fe 3 O 4 MNPs and GO nanosheets were combined to prepare Fe 3 O 4 /GO nanocomposite and subsequently conjugated with...

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Bibliographic Details
Published in:	Discover nano Vol. 19; no. 1; pp. 15 - 12
Main Authors:	Aljawrneh, Bashar, Shawakfeh, Khaled, Albiss, Borhan Aldeen, Alshanableh, Abdelelah, Al-Qudah, Mahmoud A., Bataineh, Tariq T., Shawakfeh, Lona
Format:	Journal Article
Language:	English
Published:	New York Springer US 22-01-2024 Springer Nature B.V Springer
Subjects:	Antioxidant activity Antioxidants Chemistry and Materials Science Crosslinking Crystal structure Digitonin Functionalization Graphene Graphene oxide Iron magnetite nanoparticles Iron oxides Materials Science Molecular Medicine Nanochemistry Nanocomposites Nanoparticles Nanoscale Science and Technology Nanosheets Nanotechnology Nanotechnology and Microengineering Physiochemistry Structural analysis Sulfonic acid Vibration mode X-ray diffraction Graphene oxide Functionalization Iron magnetite nanoparticles Antioxidant activity Digitonin
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Summary:	In this work, iron oxide (Fe 3 O 4 ) magnetic nanoparticles (MNPs) and graphene oxide (GO) nanosheets were prepared via the co-precipitation technique and the Modified Hummer method. Fe 3 O 4 MNPs and GO nanosheets were combined to prepare Fe 3 O 4 /GO nanocomposite and subsequently conjugated with Digitonin (DIG) in order to obtain a dual-targeted delivery system based on DIG/Fe 3 O 4 /GO nanocomposite. SEM images reveal the presence of Fe 3 O 4 MNPs at a scale of 100 nm, exhibiting dispersion between the GO nanosheets. Aggregation of the DIG/Fe 3 O 4 /GO nanocomposite was observed at various size scales. The XRD structural analysis confirms the crystal structure of the prepared samples. The Fe 3 O 4 MNPs demonstrated the main XRD-diffracted peaks. Also, GO nanosheets exhibit crystalline characteristics on the (001) and (002) planes. The predominant peaks observed in the DIG/GO/Fe 3 O 4 nanocomposite are attributed to the crystal phases of Fe 3 O 4 MNPs. The FT-IR vibrational modes observed in the GO/DIG/Fe 3 O 4 nanocomposite indicate the presence of crosslinking between GO nanosheet layers and the Fe 3 O 4 MNPs. The antioxidant activity of the prepared samples was measured and the DIG/GO/Fe 3 O 4 nanocomposite demonstrated a significantly high antioxidant activity in both 2-diphenyl-1-picrylhydrazyl (DPPH · ) and 2,2-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS ·+ ) tests.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2731-9229 1931-7573 2731-9229 1556-276X
DOI:	10.1186/s11671-024-03960-7