Search Results - "Bastounis, Effie E."

Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells by Bastounis, Effie E., Serrano-Alcalde, Francisco, Radhakrishnan, Prathima, Engström, Patrik, Gómez-Benito, María J., Oswald, Mackenzi S., Yeh, Yi-Ting, Smith, Jason G., Welch, Matthew D., García-Aznar, José M., Theriot, Julie A.

“…Intracellular pathogens alter their host cells' mechanics to promote dissemination through tissues. Conversely, host cells may respond to the presence of…”
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Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing by Faralla, Cristina, Bastounis, Effie E, Ortega, Fabian E, Light, Samuel H, Rizzuto, Gabrielle, Gao, Lei, Marciano, Denise K, Nocadello, Salvatore, Anderson, Wayne F, Robbins, Jennifer R, Theriot, Julie A, Bakardjiev, Anna I

“…During pregnancy, the placenta protects the fetus against the maternal immune response, as well as bacterial and viral pathogens. Bacterial pathogens that have…”
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Spatiotemporal characterization of endothelial cell motility and physical forces during exposure to Borrelia burgdorferi by Muenkel, Marie, Aparicio-Yuste, Raul, Tal, Michal Caspi, Kraiczy, Peter, Bastounis, Effie E.

“…Cell motility and biomechanics are critical in various (patho)physiological processes, including the regulation of vascular barrier integrity, which can be…”
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Cell-stretching devices: advances and challenges in biomedical research and live-cell imaging by Constantinou, Iordania, Bastounis, Effie E.

“…Mechanical stretching is experienced ubiquitously by human tissues and their constituent cells and impacts biochemical and (mechano)biological processes…”
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Borrelia burgdorferi modulates the physical forces and immunity signaling in endothelial cells by Yuste, Raúl Aparicio, Muenkel, Marie, Axarlis, Konstantinos, Gómez Benito, María J., Reuss, Annalena, Blacker, Grace, Tal, Michal Caspi, Kraiczy, Peter, Bastounis, Effie E.

“…Borrelia burgdorferi (Bb), a vector-borne bacterial pathogen and the causative agent of Lyme disease, can spread to distant tissues in the human host by…”
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A Stiff Extracellular Matrix Favors the Mechanical Cell Competition that Leads to Extrusion of Bacterially-Infected Epithelial Cells by Aparicio-Yuste, Raúl, Muenkel, Marie, Clark, Andrew G., Gómez-Benito, María J., Bastounis, Effie E.

“…Cell competition refers to the mechanism whereby less fit cells (“losers”) are sensed and eliminated by more fit neighboring cells (“winners”) and arises…”
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Volume measurement and biophysical characterization of mounds in epithelial monolayers after intracellular bacterial infection by Bastounis, Effie E., Radhakrishnan, Prathima, Prinz, Christopher K., Theriot, Julie A.

“…Mechanical forces are important in (patho)physiological processes, including how host epithelial cells interact with intracellular bacterial pathogens. As…”
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Integration of Extracellular Matrices into Organ‐on‐Chip Systems by Kutluk, Hazal, Bastounis, Effie E., Constantinou, Iordania

“…The extracellular matrix (ECM) is a complex, dynamic network present within all tissues and organs that not only acts as a mechanical support and anchorage…”
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Mechanical Forces Govern Interactions of Host Cells with Intracellular Bacterial Pathogens by Bastounis, Effie E, Radhakrishnan, Prathima, Prinz, Christopher K, Theriot, Julie A

“…To combat infectious diseases, it is important to understand how host cells interact with bacterial pathogens. Signals conveyed from pathogen to host, and vice…”
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Subendothelial stiffness alters endothelial cell traction force generation while exerting a minimal effect on the transcriptome by Bastounis, Effie E., Yeh, Yi-Ting, Theriot, Julie A.

“…Endothelial cells respond to changes in subendothelial stiffness by altering their migration and mechanics, but whether those responses are due to…”
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Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin by Bastounis, Effie E, Yeh, Yi-Ting, Theriot, Julie A

“…Extracellular matrix stiffness (ECM) is one of the many mechanical forces acting on mammalian adherent cells and an important determinant of cellular function…”
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Alterations of baroreflex sensitivity after carotid endarterectomy according to the preoperative carotid plaque echogenicity by Tsekouras, Nikolaos S., MD, Katsargyris, Athanasios, MD, Skrapari, Ioanna, MD, Bastounis, Effie E., EEng, MSc, Georgopoulos, Sotirios, MD, Klonaris, Chris, MD, Bakoyiannis, Chris, MD, Tsekouras, Efstathios, MD

“…Objective Baroreflex sensitivity is lower in patients with echogenic carotid plaques compared with patients with echolucent ones. The purpose of our study was…”
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The role of carotid plaque echogenicity in baroreflex sensitivity by Tsekouras, Nikolaos S., MD, Katsargyris, Athanasios, MD, Skrapari, Ioanna, MD, Bastounis, Effie E., MSc, Georgopoulos, Sotirios, MD, Klonaris, Chris, MD, Bakoyiannis, Chris, MD, Bastounis, Elias A., MD

“…Objective The baroreflex sensitivity is impaired in patients with carotid atherosclerosis. The purpose of our study was to assess the impact of carotid plaque…”
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Computational modelling of epithelial cell monolayers during infection with Listeria monocytogenes by Aparicio-Yuste, Raul, Serrano-Alcalde, Francisco, Muenkel, Marie, Garcia-Aznar, Jose Manuel, Bastounis, Effie E., Gomez-Benito, Maria Jose

“…Intracellular bacterial infections alter the normal functionality of human host cells and tissues. Infection can also modify the mechanical properties of host…”
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Increased macrophage phagocytic activity with TLR9 agonist conjugation of an anti- Borrelia burgdorferi monoclonal antibody by Jahanbani, Shaghayegh, Hansen, Paige S., Blum, Lisa K., Bastounis, Effie E., Ramadoss, Nitya S., Pandrala, Mallesh, Kirschmann, Jessica Marie, Blacker, Grace Sisemore, Love, Zelda Z., Weissman, Irving L., Nemati, Fahimeh, Tal, Michal Caspi, Robinson, William H.

“…Borrelia burgdorferi (Bb) infection causes Lyme disease, for which there is need for more effective therapies. Here, we sequenced the antibody repertoire of…”
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A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells by Bastounis, Effie E, Ortega, Fabian E, Serrano, Ricardo, Theriot, Julie A

“…Extracellular matrix stiffness comprises one of the multiple environmental mechanical stimuli that are well known to influence cellular behavior, function, and…”
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Mechanically-Driven Cellular Competition Promotes the Collective Extrusion of Bacteria-Infected Epithelial Cells by Bastounis, Effie E., Radhakrishnan, Prathima, Engström, Patrik, Alcalde, Francisco, Gómez Benito, Maria, García Aznar, José M., Welch, Matthew, Theriot, Julie

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A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells by Bastounis, Effie E, Ortega, Fabian E, Serrano, Ricardo, Theriot, Julie A

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Cortical and Cytoskeletal Structural Network regulates the Three-Dimensional Traction Forces Exerted by Migrating Amoeboid Cells by Alvarez-Gonzalez, Begona, Meili, Ruedi, Bastounis, Effie E., del Alamo, Juan C., Firtel, Richard A., Lasheras, Juan C.

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