Impact of a sepsis bundle in wards of a tertiary hospital

Impact of a sepsis bundle in wards of a tertiary hospital

Sepsis is a prevalent disease worldwide and still exhibits high rates of mortality. In the last years, many interventions aiming a positive impact on sepsis evolution have been studied. One of the main is the use of managed care protocols (sepsis bundles), which consist in systematization of diagnos...

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Published in:Journal of intensive care Vol. 5; no. 1; p. 45
Main Authors: Teles, F, Rodrigues, W G, Alves, M G T C, Albuquerque, C F T, Bastos, S M O, Mota, M F A, Mota, E S, Silva, F J L
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 18-07-2017
BioMed Central
BMC
Subjects:
3-h bundle
Analysis
Antibiotics
Care and treatment
Catheters
Comorbidity
Diagnosis
Disease
Health care costs
Hospital costs
Hospitals
Infections
Intensive care
Laboratories
Mortality
Orthopedics
Sepsis
Sepsis protocol
Services
Wards
Brazil
Wards
3-h bundle
Mortality
Sepsis protocol
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Summary:Sepsis is a prevalent disease worldwide and still exhibits high rates of mortality. In the last years, many interventions aiming a positive impact on sepsis evolution have been studied. One of the main is the use of managed care protocols (sepsis bundles), which consist in systematization of diagnosis and treatment, such as standardization of antibiotics, collection of specific tests (cultures, lactate), and fluid replacement. Some studies have shown a reduction in hospital costs and lower mortality with the use of these tools. In the present study, we evaluated the impact of a sepsis bundle in wards of a tertiary hospital. One hundred sixty-seven patients were retrospectively studied. The intervention was called "3-h bundle" and consisted of collecting lactate and cultures, start broad-spectrum antibiotics in the first hour of sepsis diagnosis, and volume replacement with crystalloid if hypotension or lactate ≥2 mmol/L. The overall mortality was 31.1%. Individuals who received the 3-h bundle showed a 44% lower mortality in comparison with who did not (25.6 vs. 45.7%;  = 0.01). Furthermore, the use of the sepsis bundle was independently correlated with lower mortality (OR = 0.175; CI = 0.04-0.64;  = 0.009). Therefore, a lower need for ICU admission and shorter length of stay in these units were observed in patients who received the intervention. The use of a sepsis protocol with systematic care in wards was associated with lower mortality, less need for ICU admission and shorter stay on these units.
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ISSN:2052-0492
2052-0492
DOI:10.1186/s40560-017-0231-2